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Study · Animal study (in vivo) · rhesus monkey · 2008

5 results

An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo.

Keen KL, Wegner FH, Bloom SR, Ghatei MA, Terasawa E

Endocrinology1 May 2008Cited by 208 (Europe PMC)

PMID18450954 (opens in a new tab)PMCIDPMC2488227 (opens in a new tab)DOI10.1210/en.2008-0231 (opens in a new tab)PepBankPUB-18450954
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rhesus monkeys, kisspeptin‑10 infusion into the stalk-median eminence significantly stimulated LHRH-1 release in a dose-dependent manner.

    In plain wordsIn female rhesus monkeys, kisspeptin‑10 infused into the brain region raised LHRH-1 release, with a larger rise at higher doses.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLHRH-1 release
    Study

    rhesus monkeyn: not reported in source

    Midpubertal female rhesus monkeys, stalk-median eminence microdialysis
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · infusion through a microdialysis probeAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Kisspeptin-10 infusion through a microdialysis probe significantly stimulated LHRH-1 release in a dose-dependent manner.
    1 context sentence
    Summary · context
    This study measures the release of kisspeptin-54 in the stalk-median eminence (S-ME) during puberty and examines its potential role in the pubertal increase in LHRH-1 release in female rhesus monkeys.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In female rhesus monkeys, the body's own kisspeptin‑54 release in the stalk-median eminence rose with puberty, together with LHRH-1 release.

    In plain wordsIn female rhesus monkeys, the body's own kisspeptin‑54 release rose during puberty along with LHRH-1 release.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseKisspeptin-54 release across puberty
    Study

    rhesus monkeyn: not reported in source

    stalk-median eminence in vivo sampling
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    a significant increase in kisspeptin-54 release occurred in association with the pubertal increase in LHRH-1 release
    1 context sentence
    Summary · context
    First, developmental changes in release of kisspeptin-54 and LHRH-1 were assessed in push-pull perfusate samples obtained from the S-ME of prepubertal, early pubertal, and midpubertal female rhesus monkeys.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In female rhesus monkeys, a nocturnal increase in the body's own kisspeptin‑54 release was present in prepubertal animals and continued through puberty.

    In plain wordsIn young female rhesus monkeys, the body's own kisspeptin‑54 release rose at night, before and during puberty.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseNocturnal kisspeptin-54 release
    Study

    rhesus monkeyn: not reported in source

    stalk-median eminence in vivo sampling
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    a nocturnal increase in kisspeptin-54 release was already observed in prepubertal monkeys and continued through the pubertal period.
    1 context sentence
    Summary · context
    First, developmental changes in release of kisspeptin-54 and LHRH-1 were assessed in push-pull perfusate samples obtained from the S-ME of prepubertal, early pubertal, and midpubertal female rhesus monkeys.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  3. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In midpubertal female rhesus monkeys, kisspeptin‑54 release was pulsatile with an interpulse interval of about 60 min.

    In plain wordsIn midpubertal female rhesus monkeys, the body's own kisspeptin‑54 was released in pulses about every 60 minutes.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKisspeptin-54 release pulse interval
    Study

    rhesus monkeyn: not reported in source

    stalk-median eminence in vivo sampling
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Interpulse interval
    ≈ 60 min
    midpubertal monkeys

    Source sentences

    Summary
    Kisspeptin-54 release in the S-ME was clearly pulsatile with an interpulse interval of about 60 min
    1 context sentence
    Summary · context
    First, developmental changes in release of kisspeptin-54 and LHRH-1 were assessed in push-pull perfusate samples obtained from the S-ME of prepubertal, early pubertal, and midpubertal female rhesus monkeys.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  4. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In midpubertal female rhesus monkeys, about 75% of kisspeptin‑54 pulses were correlated with LHRH-1 pulses.

    In plain wordsIn midpubertal female rhesus monkeys, about three in four of the body's own kisspeptin‑54 pulses lined up with LHRH-1 pulses.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKisspeptin-54 pulses matched with LHRH-1 pulses
    Study

    rhesus monkeyn: not reported in source

    stalk-median eminence in vivo sampling
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Pulses correlated with LHRH-1 pulses
    ≈ 75%
    midpubertal monkeys

    Source sentences

    Summary
    approximately 75% of kisspeptin-54 pulses were correlated with LHRH-1 pulses.
    1 context sentence
    Summary · context
    First, developmental changes in release of kisspeptin-54 and LHRH-1 were assessed in push-pull perfusate samples obtained from the S-ME of prepubertal, early pubertal, and midpubertal female rhesus monkeys.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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