Beneficial effect of luteal-phase GnRH agonist administration on embryo implantation after ICSI in both GnRH agonist- and antagonist-treated ovarian stimulation cycles.

Tesarik J, Hazout A, Mendoza-Tesarik R, Mendoza N, Mendoza C

Human reproduction (Oxford, England)22 Aug 2006Cited by 89 (Europe PMC)

PMID16926261DOI10.1093/humrep/del173PepBankPUB-16926261

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women undergoing ICSI, luteal-phase triptorelin significantly increased implantation rates versus placebo across both stimulation protocols.
In plain wordsIn women undergoing ICSI, luteal-phase triptorelin increased implantation rates compared with placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseImplantation rate
Study
n = 600
Comparator
Placebo
Analysis
Primary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · injection · Single injection on day 6 after ICSIAs given in this study (human).
Source sentences
Summary
Administration of 0.1 mg of GnRH agonist triptorelin on day 6 after ICSI led to a significant improvement of implantation and live birth rates after ICSI as compared with placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
Implantation and live birth rates were the primary outcomes.
Summary · context
Six hundred women about to undergo ovarian stimulation for ICSI (300 using a long GnRH agonist protocol and 300 using a GnRH antagonist protocol) were enrolled in this study. Patients treated with each of these two protocols were randomly assigned to receive a single injection of GnRH agonist or pla…
Report a problemFND-1692626101
02HumanRandomized controlled trialEfficacy outcome
In women undergoing ICSI, luteal-phase triptorelin significantly increased live birth rates versus placebo across both stimulation protocols.
In plain wordsIn women undergoing ICSI, luteal-phase triptorelin increased live birth rates compared with placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLive birth rate
Study
n = 600
Comparator
Placebo
Analysis
Primary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · injection · Single injection on day 6 after ICSIAs given in this study (human).
Source sentences
Summary
Administration of 0.1 mg of GnRH agonist triptorelin on day 6 after ICSI led to a significant improvement of implantation and live birth rates after ICSI as compared with placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
Implantation and live birth rates were the primary outcomes.
Summary · context
Six hundred women about to undergo ovarian stimulation for ICSI (300 using a long GnRH agonist protocol and 300 using a GnRH antagonist protocol) were enrolled in this study. Patients treated with each of these two protocols were randomly assigned to receive a single injection of GnRH agonist or pla…
Report a problemFND-1692626102
03HumanRandomized controlled trialEfficacy outcome
In women undergoing ICSI, luteal-phase triptorelin increased serum HCG in both ovarian stimulation regimens versus placebo.
In plain wordsIn women undergoing ICSI, triptorelin increased luteal serum HCG compared with placebo in both stimulation regimens.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLuteal serum HCG
Study
n = 600
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · injection · Single injection on day 6 after ICSIAs given in this study (human).
Source sentences
Summary
Moreover, luteal-phase GnRH agonist administration increased luteal-phase serum HCG, estradiol and progesterone concentrations in both ovarian stimulation regimens.
1 context sentence(design, population, supporting numbers)
Summary · context
Six hundred women about to undergo ovarian stimulation for ICSI (300 using a long GnRH agonist protocol and 300 using a GnRH antagonist protocol) were enrolled in this study. Patients treated with each of these two protocols were randomly assigned to receive a single injection of GnRH agonist or pla…
Report a problemFND-1692626104
04HumanRandomized controlled trialEfficacy outcome
In women undergoing ICSI, luteal-phase triptorelin increased serum estradiol in both ovarian stimulation regimens versus placebo.
In plain wordsIn women undergoing ICSI, triptorelin increased luteal serum estradiol compared with placebo in both stimulation regimens.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLuteal serum estradiol
Study
n = 600
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · injection · Single injection on day 6 after ICSIAs given in this study (human).
Source sentences
Summary
Moreover, luteal-phase GnRH agonist administration increased luteal-phase serum HCG, estradiol and progesterone concentrations in both ovarian stimulation regimens.
1 context sentence(design, population, supporting numbers)
Summary · context
Six hundred women about to undergo ovarian stimulation for ICSI (300 using a long GnRH agonist protocol and 300 using a GnRH antagonist protocol) were enrolled in this study. Patients treated with each of these two protocols were randomly assigned to receive a single injection of GnRH agonist or pla…
Report a problemFND-1692626105
05HumanRandomized controlled trialEfficacy outcome
In women undergoing ICSI, luteal-phase triptorelin increased serum progesterone in both ovarian stimulation regimens versus placebo.
In plain wordsIn women undergoing ICSI, triptorelin increased luteal serum progesterone compared with placebo in both stimulation regimens.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLuteal serum progesterone
Study
n = 600
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · injection · Single injection on day 6 after ICSIAs given in this study (human).
Source sentences
Summary
Moreover, luteal-phase GnRH agonist administration increased luteal-phase serum HCG, estradiol and progesterone concentrations in both ovarian stimulation regimens.
1 context sentence(design, population, supporting numbers)
Summary · context
Six hundred women about to undergo ovarian stimulation for ICSI (300 using a long GnRH agonist protocol and 300 using a GnRH antagonist protocol) were enrolled in this study. Patients treated with each of these two protocols were randomly assigned to receive a single injection of GnRH agonist or pla…
Report a problemFND-1692626106
06HumanRandomized controlled trialEfficacy outcome
In women undergoing GnRH antagonist-treated ICSI cycles, luteal-phase triptorelin increased ongoing pregnancy rates versus placebo.
In plain wordsIn women undergoing antagonist-treated ICSI cycles, triptorelin increased ongoing pregnancy rates compared with placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOngoing pregnancy rate
Study
n = 300
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · injection · Single injection on day 6 after ICSIAs given in this study (human).
Source sentences
Summary
In GnRH antagonist-treated ovarian stimulation cycles, luteal-phase GnRH agonist also increased ongoing pregnancy rate.
2 context sentences(design, population, supporting numbers)
Summary · context
Administration of 0.1 mg of GnRH agonist triptorelin on day 6 after ICSI led to a significant improvement of implantation and live birth rates after ICSI as compared with placebo.
Summary · context
Six hundred women about to undergo ovarian stimulation for ICSI (300 using a long GnRH agonist protocol and 300 using a GnRH antagonist protocol) were enrolled in this study. Patients treated with each of these two protocols were randomly assigned to receive a single injection of GnRH agonist or pla…
Report a problemFND-1692626103