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Study · Other design · 2005

3 results

Oxytocin increases trust in humans.

Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E

Nature1 Jun 2005Cited by 1,701 (Europe PMC)

PMID15931222 (opens in a new tab)DOI10.1038/nature03701 (opens in a new tab)PepBankPUB-15931222
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanOther designEfficacy outcome

    In humans, intranasal oxytocin increased trust in an interpersonal setting.

    In plain wordsIn people, oxytocin sprayed into the nose increased trust.

    Peptide
    Oxytocin
    Outcome
    IncreaseTrust in humans
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
  2. 02HumanOther designEfficacy outcome

    In humans, the effect of intranasal oxytocin on trust was not due to a general increase in readiness to bear risks.

    In plain wordsIn people, oxytocin did not make them more willing to take risks in general.

    Peptide
    Oxytocin
    Outcome
    No significant changeGeneral willingness to bear risks
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks.
  3. 03HumanOther designEfficacy outcome

    In humans, oxytocin specifically increased willingness to accept social risks that arise in interpersonal interactions.

    In plain wordsIn people, oxytocin raised willingness to accept risks that come from dealing with other people.

    Peptide
    Oxytocin
    Outcome
    IncreaseWillingness to accept social risks
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    On the contrary, oxytocin specifically affects an individual's willingness to accept social risks arising through interpersonal interactions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials11

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

11 trials · 1 ongoing · 7 completed · 1 stopped early · 3 with posted results · source ClinicalTrials.gov (opens in a new tab)

RecruitingPhase 2/3NCT06248710

Dog Presence and Oxytocin on Trust Towards Therapists

Dr. Karin Hedigern = 17629 Jan 2024 to est. 31 Dec 2024

Depressive Symptoms · Human-Animal Interaction

Trial pageClinicalTrials.govUpdated 5 Nov 2024
CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021
CompletedPhase 1NCT03060031

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

University of Colorado, Bouldern = 5121 Jun 2017 to 1 Apr 2019

Pain

Trial pageClinicalTrials.govUpdated 25 Jun 2019
CompletedNot applicableNCT03081832

Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants.

University Hospital, Toulousen = 34Jan 2017 to Dec 2018

Prader-Willi Syndrome

Trial pageClinicalTrials.govUpdated 30 Jan 2019
CompletedNot applicableNCT03114371

Oxytocin Intranasal Administrations in Children With Prader-Willi Syndrome Aged From 3 to 12 Years

University Hospital, Toulousen = 4028 Nov 2016 to 11 Jan 2019

Prader-Willi Syndrome

Trial pageClinicalTrials.govUpdated 12 Nov 2020
WithdrawnEarly phase 1NCT02361177

Role of Oxytocin in Telling and Detecting Lies

University of Texas at Austinn = 0Jan 2016 to Apr 2016

Dyssocial Behavior

Trial pageClinicalTrials.govUpdated 13 Jun 2016
Status unknownNot applicableNCT02526914

Effects of Intranasal Oxytocin and Vasopressin on Social Behavior and Decision Making

David Mankutan = 432Oct 2015 to est. Oct 2017

Healthy

Trial pageClinicalTrials.govUpdated 18 Aug 2015
CompletedPhase 1Results postedNCT01834261

Brain Dynamics of Oxytocin

Stony Brook Universityn = 51Apr 2013 to May 2015

Brain Dynamics in Healthy Adults

Trial pageClinicalTrials.govUpdated 17 Mar 2017
CompletedNot applicableResults postedNCT01312272

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

VA Greater Los Angeles Healthcare Systemn = 24Apr 2011 to Aug 2012

Schizophrenia

Trial pageClinicalTrials.govUpdated 2 May 2014
Status unknownNot applicableNCT01039766

The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)

Sheba Medical Centern = 24Feb 2010 to est. Jun 2011

Stress Disorders, Post-Traumatic

Trial pageClinicalTrials.govUpdated 9 Feb 2010
CompletedNot applicableResults postedNCT01566539

Biological Basis of Individual Variation in Social Cooperation

Emory Universityn = 707Apr 2008 to Nov 2016

Healthy

Trial pageClinicalTrials.govUpdated 25 Sept 2017

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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