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Study · Animal study (in vivo) · mouse · 2004

8 results

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.

Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA

Endocrinology24 Jun 2004Cited by 853 (Europe PMC)

PMID15217982 (opens in a new tab)DOI10.1210/en.2004-0431 (opens in a new tab)PepBankPUB-15217982
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, kisspeptin‑10 given into the lateral cerebral ventricle stimulated LH secretion.

    In plain wordsIn mice, kisspeptin‑10 given into the brain raised LH release.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH secretion after i.c.v. kisspeptin-10
    Study

    mousen: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (mouse).

    Source sentences

    Summary
    To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, kisspeptin‑54 given into the lateral cerebral ventricle stimulated LH secretion.

    In plain wordsIn mice, kisspeptin‑54 given into the brain raised luteinizing hormone.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLH secretion after intracerebroventricular dosing
    Study

    mousen: not reported in source

    mouse
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, kisspeptin‑54 stimulated LH secretion at doses as low as 1 fmol.

    In plain wordsIn mice, a very small dose of kisspeptin‑54 given into the brain raised luteinizing hormone.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLH secretion at doses as low as 1 fmol
    Study

    mousen: not reported in source

    mouse
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    as low as 1 fmol · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    it stimulated both LH and FSH secretion, at doses as low as 1 fmol
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, kisspeptin‑54 stimulated FSH secretion at doses as low as 1 fmol.

    In plain wordsIn mice, a very small dose of kisspeptin‑54 given into the brain raised follicle-stimulating hormone.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseFSH secretion at doses as low as 1 fmol
    Study

    mousen: not reported in source

    mouse
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    as low as 1 fmol · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    it stimulated both LH and FSH secretion, at doses as low as 1 fmol
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, pretreatment with the GnRH antagonist acyline blocked the kisspeptin‑54 effect on LH secretion.

    In plain wordsIn mice, a drug that blocks GnRH stopped kisspeptin‑54 from raising luteinizing hormone.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeLH stimulation after GnRH antagonist pretreatment
    Study

    mousen: not reported in source

    mouse
    Comparator
    Acyline pretreatment
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    moreover, this effect was shown to be blocked by pretreatment with acyline, a potent GnRH antagonist.
    1 context sentence
    Summary · context
    it stimulated both LH and FSH secretion, at doses as low as 1 fmol
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, pretreatment with the GnRH antagonist acyline blocked the kisspeptin‑54 effect on FSH secretion.

    In plain wordsIn mice, a drug that blocks GnRH stopped kisspeptin‑54 from raising follicle-stimulating hormone.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeFSH stimulation after GnRH antagonist pretreatment
    Study

    mousen: not reported in source

    mouse
    Comparator
    Acyline pretreatment
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    moreover, this effect was shown to be blocked by pretreatment with acyline, a potent GnRH antagonist.
    1 context sentence
    Summary · context
    it stimulated both LH and FSH secretion, at doses as low as 1 fmol

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 07AnimalEndogenous levelAnimal study (in vivo)Other

    In the mouse hypothalamus, KiSS-1 (kisspeptin gene) mRNA was found in the anteroventral periventricular, periventricular and arcuate nuclei.

    In plain wordsIn mice, the gene for the body's own kisspeptin was active in brain areas that control reproductive hormones.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKiSS-1 mRNA distribution in the hypothalamus
    Study

    mousen: not reported in source

    hypothalamus
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus.
    1 context sentence
    Summary · context
    To learn more about the functional anatomy of kisspeptins, we mapped the distribution of KiSS-1 mRNA in the hypothalamus.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 08AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice, KiSS-1 mRNA was expressed in hypothalamic areas including the anteroventral periventricular nucleus, the periventricular nucleus and the arcuate nucleus.

    In plain wordsIn mice, the gene for the body's own kisspeptin was active in brain areas that control reproductive hormones.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKiSS-1 mRNA distribution in hypothalamus
    Study

    mousen: not reported in source

    mouse hypothalamus
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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