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Study · In vitro (cells) · 2002

7 results

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.

Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N and 8 more

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Bussolino F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Graziani A

The Journal of cell biology16 Dec 2002Cited by 525 (Europe PMC)

PMID12486113 (opens in a new tab)PMCIDPMC2173981 (opens in a new tab)DOI10.1083/jcb.200207165 (opens in a new tab)PepBankPUB-12486113
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cardiovascular cells, hexarelin recognized the binding sites shared by ghrelin and des-acyl ghrelin.

    In plain wordsIn lab tests on heart cells, hexarelin attached to the same binding sites as ghrelin and des-acyl ghrelin.

    Peptide
    Hexarelin
    Outcome
    Not applicableBinding to common ghrelin and des-acyl ghrelin sites
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites, inhibit cell death, and activate MAPK and Akt
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.
  2. 02LabIn vitro (cells)Efficacy outcome

    In the cardiovascular cells studied, hexarelin inhibited cell death.

    In plain wordsIn lab tests on cells, hexarelin reduced cell death.

    Peptide
    Hexarelin
    Outcome
    DecreaseCell death
    Study

    n: not reported in source

    Outcome group
    Cell proliferation and differentiation · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites, inhibit cell death, and activate MAPK and Akt
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.
  3. 03LabIn vitro (cells)Mechanism

    In cardiovascular cells, hexarelin activated the MAPK and Akt signalling kinases.

    In plain wordsIn lab tests on heart and blood vessel cells, hexarelin switched on two cell survival signals, MAPK and Akt.

    Peptide
    Hexarelin
    Outcome
    IncreaseMAPK and Akt activation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites, inhibit cell death, and activate MAPK and Akt
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.
  4. 04LabIn vitro (cells)Mechanism

    In cell assays, MK-0677 recognized the common ghrelin and des-acyl ghrelin binding sites.

    In plain wordsIn cells, MK-0677 recognized binding sites shared by ghrelin and des-acyl ghrelin.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableCommon ghrelin binding site recognition
    Study

    n: not reported in source

    Cardiomyocytes and endothelial cells in vitro
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites,
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cell assays, MK-0677 inhibited cell death.

    In plain wordsIn cells, MK-0677 reduced cell death.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseCell death
    Study

    n: not reported in source

    Cardiomyocytes and endothelial cells in vitro
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites, inhibit cell death,
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.
  6. 06LabIn vitro (cells)Mechanism

    In cell assays, MK-0677 activated MAPK.

    In plain wordsIn cells, MK-0677 activated MAPK signaling.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseMAPK activation
    Study

    n: not reported in source

    Cardiomyocytes and endothelial cells in vitro
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites, inhibit cell death, and activate MAPK and Akt.
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.
  7. 07LabIn vitro (cells)Mechanism

    In cell assays, MK-0677 activated Akt.

    In plain wordsIn cells, MK-0677 activated Akt signaling.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseAkt activation
    Study

    n: not reported in source

    Cardiomyocytes and endothelial cells in vitro
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, both MK-0677 and hexarelin, a nonpeptidyl and a peptidyl synthetic GHS, respectively, recognize the common ghrelin and des-acyl ghrelin binding sites, inhibit cell death, and activate MAPK and Akt.
    1 context sentence
    Summary · context
    Here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and H9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and Akt serine kinases.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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