Use of GnRH agonist and human chorionic gonadotrophin tests for differentiating constitutional delayed puberty from gonadotrophin deficiency in boys.

Kauschansky A, Dickerman Z, Phillip M, Weintrob N, Strich D

Clinical endocrinology1 May 2002Cited by 24 (Europe PMC)

PMID12030910DOI10.1046/j.1365-2265.2002.01520.xPepBankPUB-12030910

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. 2 results from people.

01HumanObservational studyActivity measurement
In boys with delayed puberty, the LH response to GnRH was higher in those who entered spontaneous puberty (group A) than in those who stayed prepubertal (group B).
In plain wordsIn boys with delayed puberty, those who entered puberty had a higher LH response to GnRH than those who stayed prepubertal.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableLH response to GnRH, group A versus group B
Study
n = 32
Comparator
Group B (remained prepubertal)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.1 mg/m2 · intravenousAs given in this study (human).
Measurements
LH response
11.4 mIU/ml
group A
LH response
2.7 mIU/ml
group B
Source sentences
Summary
response to GnRH (LH, 11.4 +/- 4.4 vs. 2.7 +/- 1.1 mIU/ml, P < 0.0001
2 context sentences(design, population, supporting numbers)
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
Report a problemFND-1203091001
02HumanObservational studyActivity measurement
In boys with delayed puberty, the FSH response to GnRH was higher in group A than in group B.
In plain wordsIn boys with delayed puberty, those who entered puberty had a higher FSH response to GnRH than those who stayed prepubertal.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableFSH response to GnRH, group A versus group B
Study
n = 32
Comparator
Group B (remained prepubertal)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.1 mg/m2 · intravenousAs given in this study (human).
Measurements
FSH response
5.1 mIU/ml
group A
FSH response
2.5 mIU/ml
group B
Source sentences
Summary
FSH, 5.1 +/- 3.4 vs. 2.5 +/- 2.4 mIU/ml, P < 0.0001
2 context sentences(design, population, supporting numbers)
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
Report a problemFND-1203091002

Studies that did not test the peptide alone5

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

03HumanNot a test of Gonadorelin (GnRH, LHRH) aloneObservational studyActivity measurement
In boys with delayed puberty, the LH response to the GnRH agonist Decapeptyl was significantly higher in group A than in group B, with no overlap and a cut-off of 8.0 mIU/ml.
In plain wordsIn boys with delayed puberty, those who entered puberty had a higher LH response to the GnRH agonist Decapeptyl than those who stayed prepubertal.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableLH response to GnRH agonist, group A versus group B
Study
n = 32
Comparator
Group B (remained prepubertal)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
LH response
20.4 mIU/ml
group A
LH response
2.3 mIU/ml
group B
LH response cut-off
8 mIU/ml
GnRH-a
Source sentences
Summary
The LH response to GnRH-a and the testosterone response to hCG stimulation were significantly higher in group A (LH, mean +/- SD 20.4 +/- 7.5 mIU/ml, range 10.8-32.6; testosterone, mean +/- SD 18.0 +/- 5.9 nmol/l, range 9.4-26, P < 0.0001) than in group B (LH, mean +/- SD 2.3 +/- 2.0 mIU/ml, range 0.7-6.9
3 context sentences(design, population, supporting numbers)
Summary · context
The cut-off for the LH response to GnRH-a was 8.0 mIU/ml
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-1203091003
04HumanNot a test of Gonadorelin (GnRH, LHRH) aloneObservational studyActivity measurement
In boys with delayed puberty, serum testosterone 4 h after the GnRH agonist was higher in group A than in group B, with a great overlap in range.
In plain wordsIn boys with delayed puberty, testosterone 4 hours after the GnRH agonist was higher in those who entered puberty, but the ranges overlapped.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableTestosterone 4 h after GnRH agonist, group A versus group B
Study
n = 32
Comparator
Group B (remained prepubertal)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Testosterone
1.9 nmol/l
group A
Testosterone
0.9 nmol/l
group B
Source sentences
Summary
mean serum testosterone level at 4 h after GnRH-a administration (1.9 +/- 1.0 vs. 0.9 +/- 0.4 nmol/l, P = 0.002
2 context sentences(design, population, supporting numbers)
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-1203091004
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In boys with delayed puberty, the LH response to triptorelin was higher in those entering spontaneous puberty than those remaining prepubertal, without overlap.
In plain wordsBoys who entered spontaneous puberty had a higher LH response to triptorelin than boys who remained prepubertal, without overlap.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLH response to triptorelin
Study
n = 32
Comparator
Boys who remained prepubertal (group B)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Mean LH response
20.4 mIU/ml
group A
Mean LH response
2.3 mIU/ml
group B
Source sentences
Summary
The LH response to GnRH-a and the testosterone response to hCG stimulation were significantly higher in group A (LH, mean +/- SD 20.4 +/- 7.5 mIU/ml, range 10.8-32.6;
4 context sentences(design, population, supporting numbers)
Summary · context
than in group B (LH, mean +/- SD 2.3 +/- 2.0 mIU/ml, range 0.7-6.9; testosterone, mean +/- SD 1.0 +/- 0.7 nmol/l, range 0.7-3.2), with no overlap between the groups.
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
Thirteen entered spontaneous puberty within 1 year of referral (group A) and 19 remained prepubertal (group B).
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1203091005
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In boys with delayed puberty, the cut-off for the LH response to triptorelin was 8.0 mIU/ml.
In plain wordsIn boys with delayed puberty, the diagnostic cut-off for the LH response to triptorelin was 8.0 mIU/ml.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableLH diagnostic cut-off
Study
n = 32
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
LH response cut-off
8 mIU/ml
GnRH agonist test
Source sentences
Summary
The cut-off for the LH response to GnRH-a was 8.0 mIU/ml,
3 context sentences(design, population, supporting numbers)
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
Thirteen entered spontaneous puberty within 1 year of referral (group A) and 19 remained prepubertal (group B).
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1203091006
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In boys with delayed puberty, testosterone after triptorelin was higher in those entering spontaneous puberty than those remaining prepubertal, with substantial overlap.
In plain wordsBoys who entered spontaneous puberty had higher testosterone after triptorelin than boys who remained prepubertal, but the ranges overlapped.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseTestosterone at 4 h after triptorelin
Study
n = 32
Comparator
Boys who remained prepubertal (group B)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Mean serum testosterone
1.9 nmol/l
group A; 4 h after GnRH agonist
Mean serum testosterone
0.9 nmol/l
group B; 4 h after GnRH agonist
Source sentences
Summary
and mean serum testosterone level at 4 h after GnRH-a administration (1.9 +/- 1.0 vs. 0.9 +/- 0.4 nmol/l, P = 0.002), but all showed a great overlap in range.
3 context sentences(design, population, supporting numbers)
Summary · context
PATIENTS, METHODS AND DESIGN: The study sample included 32 prepubertal boys aged 14 years or older.
Summary · context
Thirteen entered spontaneous puberty within 1 year of referral (group A) and 19 remained prepubertal (group B).
Summary · context
All underwent the GnRH test (Relefact, Hoechst AG, 0.1 mg/m2 i.v. in one bolus), GnRH-a test (Decapeptyl, Ferring GmbH, 0.1 mg/m2 s.c.) and hCG stimulation (Chorigon, Teva, 1500 units i.m. on three alternate days) at 1-week intervals.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1203091007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 3 to 4Current
21 Oct 2026, 18:59 UTC
The same notice was added 2 times, first on 14 Oct 2026, 01:46 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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