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Study · Ex vivo tissue · rat · 2001

14 results

Role of endothelial cells in modulation of contractility induced by hexarelin in rat ventricle.

Bedendi I, Gallo MP, Malan D, Levi RC, Alloatti G

Life sciences1 Sept 2001Cited by 12 (Europe PMC)

PMID11669462 (opens in a new tab)DOI10.1016/s0024-3205(01)01312-1 (opens in a new tab)PepBankPUB-11669462
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In rat papillary muscles treated with hexarelin, recovery of contractility after anoxia was improved.

    In plain wordsIn rat heart muscle tissue, hexarelin improved recovery of contraction after oxygen shortage.

    Peptide
    Hexarelin
    Outcome
    IncreaseRecovery of contractility after anoxia
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    We observed, in hexarelin treated papillary muscles, an improved recovery of contractility after anoxia.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  2. 02LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, hexarelin caused a transient increase in contractile force that propranolol abolished.

    In plain wordsIn rat heart muscle tissue, hexarelin briefly increased contraction force, and propranolol blocked this.

    Peptide
    Hexarelin
    Outcome
    IncreaseTransient contractile force
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    These effects were a transient increase in contractile force, abolished by propranolol (0.2 microM)
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  3. 03LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, hexarelin reduced contractile force at low beating frequencies (60-240/min).

    In plain wordsIn rat heart muscle tissue, hexarelin later reduced contraction force at slow beating rates.

    Peptide
    Hexarelin
    Outcome
    DecreaseContractile force at low beating frequencies
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    followed by a reduction at low (60-240/min), but not at high (400-600/min) beating frequencies.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  4. 04LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, hexarelin did not reduce contractile force at high beating frequencies (400-600/min).

    In plain wordsIn rat heart muscle tissue, hexarelin did not reduce contraction force at fast beating rates.

    Peptide
    Hexarelin
    Outcome
    No significant changeContractile force at high beating frequencies
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    followed by a reduction at low (60-240/min), but not at high (400-600/min) beating frequencies.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  5. 05LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, hexarelin modified the typical negative force-frequency relationship.

    In plain wordsIn rat heart muscle tissue, hexarelin changed how contraction force varies with beating rate.

    Peptide
    Hexarelin
    Outcome
    MixedForce-frequency relationship
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    The typical negative force-frequency relationship present in rat papillary muscles was therefore modified
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  6. 06LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, a minor increase in diastolic tension occurred after a sudden increase in stimulus frequency with hexarelin.

    In plain wordsIn rat heart muscle tissue, hexarelin was followed by a small rise in resting tension after a sudden speed-up.

    Peptide
    Hexarelin
    Outcome
    IncreaseDiastolic tension after a sudden increase in stimulus frequency
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    a minor increase in diastolic tension occurred after a sudden increase in stimulus frequency.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  7. 07LabEx vivo tissueMechanism

    In rat papillary muscles, blockade of nitric oxide synthesis with L-NAME partially altered the response to hexarelin.

    In plain wordsIn rat heart muscle tissue, blocking nitric oxide production partly changed the response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    Not applicableEffect of NO synthesis blockade on the hexarelin response
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    Blockade of NO synthesis with 1 mM L-NAME, partially altered the response to hexarelin.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  8. 08LabEx vivo tissueMechanism

    In rat papillary muscles pre-treated with indomethacin, the remaining effects of hexarelin were absent.

    In plain wordsIn rat heart muscle tissue, indomethacin removed the remaining effects of hexarelin.

    Peptide
    Hexarelin
    Outcome
    Not applicableEffect of indomethacin on the remaining hexarelin effects
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    The remaining effects of hexarelin were absent in papillary muscles pre-treated with indomethacin (1 microM), or after removal of endocardial endothelium with 0.5% triton X-100.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  9. 09LabEx vivo tissueMechanism

    In rat papillary muscles, the remaining effects of hexarelin were absent after removal of the endocardial endothelium.

    In plain wordsIn rat heart muscle tissue, removing the inner lining cells removed the remaining effects of hexarelin.

    Peptide
    Hexarelin
    Outcome
    Not applicableEffect of endocardial endothelium removal on the remaining hexarelin effects
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    The remaining effects of hexarelin were absent in papillary muscles pre-treated with indomethacin (1 microM), or after removal of endocardial endothelium with 0.5% triton X-100.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  10. 10LabEx vivo tissueMechanism

    In hexarelin treated rat papillary muscles, release of the prostacyclin metabolite 6-keto-PGF1alpha increased during reoxygenation after anoxia.

    In plain wordsIn rat heart muscle tissue, hexarelin was followed by more release of a prostacyclin breakdown product after oxygen shortage.

    Peptide
    Hexarelin
    Outcome
    Increase6-keto-PGF1alpha release during reoxygenation
    Study

    ratn: not reported in source

    rat papillary muscle
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    The release of the prostacyclin metabolite 6-keto-PGF1alpha was increased during reoxygenation after a period of anoxia in hexarelin treated papillary muscles.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  11. 11LabEx vivo tissueMechanism

    In isolated rat ventricular cells, hexarelin had no significant effect on calcium transients.

    In plain wordsIn isolated rat heart cells, hexarelin did not change calcium transients.

    Peptide
    Hexarelin
    Outcome
    No significant changeCalcium transients in isolated ventricular cells
    Study

    ratn: not reported in source

    isolated ventricular cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin had no significant effect on calcium transients and on I(Ca) measured in isolated ventricular cells.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  12. 12LabEx vivo tissueMechanism

    In isolated rat ventricular cells, hexarelin had no significant effect on the calcium current I(Ca).

    In plain wordsIn isolated rat heart cells, hexarelin did not change the calcium current.

    Peptide
    Hexarelin
    Outcome
    No significant changeCalcium current I(Ca) in isolated ventricular cells
    Study

    ratn: not reported in source

    isolated ventricular cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1-10 microMAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin had no significant effect on calcium transients and on I(Ca) measured in isolated ventricular cells.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  13. 13LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, MK‑677 reduced contractility.

    In plain wordsIn lab tests, MK‑677 reduced the contraction strength of rat heart muscle.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseContractility
    Study

    ratn: not reported in source

    papillary muscles
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 microMAs given in this study (rat).

    Source sentences

    Summary
    MK-677 (1 microM), a non peptidyl GH secretagogue, reduced contractility, but did not alter the force-frequency relationship.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.
  14. 14LabEx vivo tissueEfficacy outcome

    In rat papillary muscles, MK‑677 did not alter the force-frequency relationship.

    In plain wordsIn lab tests, MK‑677 did not change how rat heart muscle contraction strength varied with beating frequency.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeForce-frequency relationship
    Study

    ratn: not reported in source

    papillary muscles
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 microMAs given in this study (rat).

    Source sentences

    Summary
    MK-677 (1 microM), a non peptidyl GH secretagogue, reduced contractility, but did not alter the force-frequency relationship.
    1 context sentence
    Summary · context
    To investigate the mechanisms of its cardiac activity, we studied the effects of hexarelin (1-10 microM) on contractility of rat papillary muscles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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