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Study · Ex vivo tissue · 2001

2 results

Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.

Muccioli G, Papotti M, Locatelli V, Ghigo E, Deghenghi R

Journal of endocrinological investigation1 Mar 2001Cited by 107 (Europe PMC)

PMID11314756 (opens in a new tab)DOI10.1007/bf03343831 (opens in a new tab)PepBankPUB-11314756
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In human hypothalamic membranes, hexarelin displaced bound 125I-ghrelin.

    In plain wordsIn lab tests on human brain membranes, hexarelin competed with ghrelin for the same binding sites.

    Peptide
    Hexarelin
    Outcome
    Not applicableDisplacement of 125I-ghrelin binding
    Study

    humann: not reported in source

    Human hypothalamus membranes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    125I-ghrelin bound to hypothalamic membranes was displaced by ghrelin, hexarelin, MK-0677, various GHS antagonists (EP-80317, [D-Arg1-D-Phe5-D-Trp7,9-Leu11]-substance P) and some natural (cortistatin-14) and synthetic (vapreotide) SRIH-14 agonists.
    1 context sentence
    Summary · context
    Herein we studied: 1) the binding of 125I-labeled human ghrelin to membranes from human hypothalamus and pituitary gland; 2) the ability of human ghrelin (either octanoylated or desoctanoylated), as well as of some GHS and neuropeptides to compete with the radioligand.
  2. 02LabIn vitro (cell-free)Activity measurement

    In human hypothalamic membranes, MK-0677 displaced bound radiolabeled ghrelin.

    In plain wordsIn lab tests with human hypothalamic membranes, MK-0677 displaced bound radiolabeled ghrelin.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableGhrelin radioligand displacement
    Study

    humann: not reported in source

    Human hypothalamic membranes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    125I-ghrelin bound to hypothalamic membranes was displaced by ghrelin, hexarelin, MK-0677, various GHS antagonists (EP-80317, [D-Arg1-D-Phe5-D-Trp7,9-Leu11]-substance P) and some natural (cortistatin-14) and synthetic (vapreotide) SRIH-14 agonists.
    1 context sentence
    Summary · context
    Herein we studied: 1) the binding of 125I-labeled human ghrelin to membranes from human hypothalamus and pituitary gland; 2) the ability of human ghrelin (either octanoylated or desoctanoylated), as well as of some GHS and neuropeptides to compete with the radioligand.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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