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Study · In vitro (cell-free) · 2001

2 results

Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland.

Deghenghi R, Papotti M, Ghigo E, Muccioli G

Journal of endocrinological investigation1 Jan 2001Cited by 91 (Europe PMC)

PMID11227737 (opens in a new tab)DOI10.1007/bf03343800 (opens in a new tab)PepBankPUB-11227737
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In human pituitary membranes, unlabelled hexarelin completely displaced the binding of 125I-Tyr-Ala-hexarelin.

    In plain wordsIn lab tests with human pituitary membranes, hexarelin fully displaced a labeled hexarelin derivative from its binding sites.

    Peptide
    Hexarelin
    Outcome
    DecreaseDisplacement of 125I-Tyr-Ala-hexarelin binding
    Study

    humann: not reported in source

    human pituitary membranes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    While the binding of 125I-Tyr-Ala-hexarelin to pituitary membranes was completely displaced by unlabelled hexarelin, ghrelin and CST
  2. 02LabIn vitro (cell-free)Activity measurement

    In human pituitary membranes, hexarelin was about four orders of magnitude more effective than ghrelin and cortistatin-14 in displacing 125I-Tyr-Ala-hexarelin.

    In plain wordsIn lab tests with human pituitary membranes, hexarelin displaced the labeled derivative far more effectively than ghrelin or cortistatin.

    Peptide
    Hexarelin
    Outcome
    Not applicableDisplacement potency compared with ghrelin and cortistatin-14
    Study

    humann: not reported in source

    human pituitary membranes
    Comparator
    Ghrelin and cortistatin-14
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and CST exhibited a similar affinity (4.6-5.4 x 10(-7) mol/l) for the binding while hexarelin was more effective by about four orders of magnitude in displacing 125I-Tyr-Ala-hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    27 Oct 2026, 16:36 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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