Skip to content

Study · Randomized controlled trial · n = 9 · 2000

3 results

Desmopressin and hexarelin tests in alcohol-induced pseudo-Cushing's syndrome.

Coiro V, Volpi R, Capretti L, Caffarri G, Chiodera P

Journal of internal medicine1 Jun 2000Cited by 13 (Europe PMC)

PMID10886488 (opens in a new tab)DOI10.1046/j.1365-2796.2000.00676.x (opens in a new tab)PepBankPUB-10886488
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In normal controls, hexarelin slightly increased ACTH and cortisol secretion.

    In plain wordsIn healthy adults, hexarelin caused a small rise in the stress hormones ACTH and cortisol.

    Peptide
    Hexarelin
    Outcome
    IncreaseACTH and cortisol response to hexarelin in normal controls
    Study

    n = 9

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microgram kg-1 · intravenousAs given in this study (human).

    Source sentences

    Summary
    whereas hexarelin, but not desmopressin, slightly increased ACTH/cortisol secretion in the normal controls.
    2 context sentences
    Summary · context
    Eight alcoholics with pseudo-Cushing's syndrome, six patients with Cushing's disease and nine age-matched normal controls.
    Summary · context
    The desmopressin (10 microg intravenously at 09:00 h) test and hexarelin (2 microgram kg-1 intravenously at 09:00 h) test were carried out in random order.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In alcoholics with pseudo-Cushing's syndrome, hexarelin caused no significant change in ACTH or cortisol secretion.

    In plain wordsIn people with alcohol-related pseudo-Cushing's syndrome, hexarelin did not significantly change ACTH or cortisol.

    Peptide
    Hexarelin
    Outcome
    No significant changeACTH and cortisol response to hexarelin in alcohol-dependent pseudo-Cushing's syndrome
    Study

    n = 8

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microgram kg-1 · intravenousAs given in this study (human).

    Source sentences

    Summary
    Neither desmopressin nor hexarelin administration induced any significant change in ACTH/cortisol secretion in alcoholics.
    2 context sentences
    Summary · context
    Eight alcoholics with pseudo-Cushing's syndrome, six patients with Cushing's disease and nine age-matched normal controls.
    Summary · context
    The desmopressin (10 microg intravenously at 09:00 h) test and hexarelin (2 microgram kg-1 intravenously at 09:00 h) test were carried out in random order.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with Cushing's disease, hexarelin induced striking ACTH and cortisol responses.

    In plain wordsIn people with Cushing's disease, hexarelin caused a strong rise in the stress hormones ACTH and cortisol.

    Peptide
    Hexarelin
    Outcome
    IncreaseACTH and cortisol response to hexarelin in Cushing's disease
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    2 microgram kg-1 · intravenousAs given in this study (human).

    Source sentences

    Summary
    Both desmopressin and hexarelin induced striking ACTH/cortisol responses in patients with Cushing's disease
    2 context sentences
    Summary · context
    Eight alcoholics with pseudo-Cushing's syndrome, six patients with Cushing's disease and nine age-matched normal controls.
    Summary · context
    The desmopressin (10 microg intravenously at 09:00 h) test and hexarelin (2 microgram kg-1 intravenously at 09:00 h) test were carried out in random order.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.