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Study · In vitro (cells) · 1999

6 results

Pharmacological characterisation of a new oral GH secretagogue, NN703.

Hansen BS, Raun K, Nielsen KK, Johansen PB, Hansen TK, Peschke B, Lau J, Andersen PH, Ankersen M

European journal of endocrinology1 Aug 1999Cited by 37 (Europe PMC)

PMID10427162 (opens in a new tab)DOI10.1530/eje.0.1410180 (opens in a new tab)PepBankPUB-10427162
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In BHK cells expressing the human GHS-R 1A, GHRP‑6 inhibited binding of 35S-MK677 to the receptor.

    In plain wordsIn lab cells carrying the human growth hormone secretagogue receptor, GHRP‑6 reduced the binding of a reference compound.

    Peptide
    GHRP-6
    Outcome
    DecreaseInhibition of 35S-MK677 binding to GHS-R 1A
    Study

    n: not reported in source

    BHK cells stably expressing human GHS-R 1A
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Binding of (35)S-MK677 to the human type 1A GHS receptor (GHS-R 1A) stably expressed on BHK cells was inhibited by GHRP-6 and MK677 as expected.
  2. 02LabIn vitro (cells)Activity measurement

    In BHK cells expressing human GHS-R 1A, unlabeled MK677 inhibited radiolabeled MK677 binding.

    In plain wordsIn cells, MK677 blocked labeled MK677 binding to the human receptor.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseRadiolabeled MK677 binding inhibition
    Study

    n: not reported in source

    BHK cells expressing human GHS-R 1A
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Binding of (35)S-MK677 to the human type 1A GHS receptor (GHS-R 1A) stably expressed on BHK cells was inhibited by GHRP-6 and MK677 as expected.
  3. 03LabIn vitro (cells)Activity measurement

    In BHK cells expressing human GHS-R 1A, MK677 was more potent than NN703 at inducing inositol phosphate turnover.

    In plain wordsIn cells, MK677 stimulated the receptor's chemical signaling more potently than NN703.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseInositol phosphate turnover potency
    Study

    n: not reported in source

    BHK cells expressing human GHS-R 1A
    Comparator
    NN703
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similarly, the effect of NN703 on the GHS-R 1A-induced inositol phosphate turnover in these cells showed a lower potency, when compared with GHRP-6 and MK677, than that observed in rat pituitary cells.
    1 context sentence
    Summary · context
    Binding of (35)S-MK677 to the human type 1A GHS receptor (GHS-R 1A) stably expressed on BHK cells was inhibited by GHRP-6 and MK677 as expected.

Studies that did not test the peptide alone3

In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MK-677 (ibutamoren).

  1. 04LabNot a test of MK-677 (ibutamoren) aloneIn vitro (cells)Activity measurement

    In BHK cells expressing human GHS-R 1A, NN703 inhibited radiolabeled MK677 binding.

    In plain wordsIn cells, NN703 blocked labeled MK677 binding to the human receptor.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseRadiolabeled MK677 binding inhibition by NN703
    Study

    n: not reported in source

    BHK cells expressing human GHS-R 1A
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    NN703 was also able to inhibit the binding of (35)S-MK677.
    1 context sentence
    Summary · context
    Binding of (35)S-MK677 to the human type 1A GHS receptor (GHS-R 1A) stably expressed on BHK cells was inhibited by GHRP-6 and MK677 as expected.

    In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).

  2. 05LabNot a test of MK-677 (ibutamoren) aloneIn vitro (cells)Activity measurement

    In BHK cells expressing human GHS-R 1A, GHRP-6 inhibited radiolabeled MK677 binding.

    In plain wordsIn cells, GHRP-6 blocked labeled MK677 binding to the human receptor.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseRadiolabeled MK677 binding inhibition by GHRP-6
    Study

    n: not reported in source

    BHK cells expressing human GHS-R 1A
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Binding of (35)S-MK677 to the human type 1A GHS receptor (GHS-R 1A) stably expressed on BHK cells was inhibited by GHRP-6 and MK677 as expected.

    In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).

  3. 06LabNot a test of MK-677 (ibutamoren) aloneIn vitro (cells)Activity measurement

    In the radiolabeled MK677 binding assay, NN703 had a lower Ki than expected from its rat pituitary GH-release potency.

    In plain wordsIn cells, NN703 had a lower binding inhibition constant than expected from its growth hormone release potency in rat pituitary cells.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    DecreaseNN703 binding inhibition Ki relative to expectation
    Study

    n: not reported in source

    BHK cells expressing human GHS-R 1A
    Comparator
    Expected Ki based on GH release from rat pituitary cells
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    However, the observed K(i) value was lower than expected, as based on the observed potencies regarding GH release from rat pituitary cells.
    2 context sentences
    Summary · context
    NN703 was also able to inhibit the binding of (35)S-MK677.
    Summary · context
    Binding of (35)S-MK677 to the human type 1A GHS receptor (GHS-R 1A) stably expressed on BHK cells was inhibited by GHRP-6 and MK677 as expected.

    In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 26 to 43Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 18 times, first on 14 Oct 2026, 05:01 UTC. The status did not change between them.

    Study results updated

  2. Version 25

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  3. Versions 3 to 24

    13 Oct 2026, 21:46 UTC

    The same notice was added 22 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  4. Version 2

    9 Oct 2026, 03:13 UTC

    Study data updated · source update from Europe PMC

  5. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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