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Study · Animal study (in vivo) · 1998

15 results

[The neurotropic activity of peptide immunomodulators].

Grechko AT

Eksperimental'naia i klinicheskaia farmakologiia1 Jul 1998

PMID9783100 (opens in a new tab)PepBankPUB-09783100
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In animals, Cerebrolysin showed a neuromodulating effect comparable with known drugs.

    In plain wordsIn animals, Cerebrolysin showed a neuromodulating effect comparable with known drugs.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableNeuromodulating effect
    Study

    n: not reported in source

    Open-field behavior monitoring
    Comparator
    Known drugs
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
    1 context sentence
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In animals, thymalin showed a neuromodulating effect comparable with known drugs.

    In plain wordsIn animals, thymalin showed a neuromodulating effect comparable with known drugs.

    Peptide
    Thymalin
    Outcome
    Not applicableNeuromodulating effect
    Study

    n: not reported in source

    Open-field behavior monitoring
    Comparator
    Known drugs
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
    1 context sentence
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In animals, Cerebrolysin changed circadian rhythms of motor activity.

    In plain wordsIn animals, Cerebrolysin changed daily motor activity rhythms.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedCircadian motor activity rhythms
    Study

    n: not reported in source

    Open-field behavior monitoring
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    2 context sentences
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In animals, thymalin changed circadian rhythms of motor activity.

    In plain wordsIn animals, thymalin changed daily motor activity rhythms.

    Peptide
    Thymalin
    Outcome
    Direction not reportedCircadian motor activity rhythms
    Study

    n: not reported in source

    Open-field behavior monitoring
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    2 context sentences
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In animals, Cerebrolysin ranked below ethymizol and above thymalin and the remaining listed drugs for activity relative to control.

    In plain wordsIn animals, Cerebrolysin ranked below ethymizol and above thymalin and the remaining listed drugs for activity relative to control.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableRelative neurotropic activity rank
    Study

    n: not reported in source

    Open-field behavior monitoring
    Comparator
    Ethymizol, thymalin, nootropil, thymogen, T-activin, cortexin and dibazol
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    1 context sentence
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In animals, thymalin ranked below ethymizol and Cerebrolysin and above the remaining listed drugs for activity relative to control.

    In plain wordsIn animals, thymalin ranked below ethymizol and Cerebrolysin and above the remaining listed drugs for activity relative to control.

    Peptide
    Thymalin
    Outcome
    Not applicableRelative neurotropic activity rank
    Study

    n: not reported in source

    Open-field behavior monitoring
    Comparator
    Ethymizol, cerebrolysin, nootropil, thymogen, T-activin, cortexin and dibazol
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    1 context sentence
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  7. 07AnimalAnimal study (in vivo)Activity measurement

    In animals, Cerebrolysin changed the dynamics of extinction of the orientation-investigation reaction.

    In plain wordsIn animals, Cerebrolysin changed how the exploratory response declined over time.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedOrientation-investigation response extinction
    Study

    n: not reported in source

    Open-field behavior monitoring
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    2 context sentences
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
  8. 08AnimalAnimal study (in vivo)Activity measurement

    In animals, thymalin changed the dynamics of extinction of the orientation-investigation reaction.

    In plain wordsIn animals, thymalin changed how the exploratory response declined over time.

    Peptide
    Thymalin
    Outcome
    Direction not reportedOrientation-investigation response extinction
    Study

    n: not reported in source

    Open-field behavior monitoring
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    2 context sentences
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
  9. 09AnimalAnimal study (in vivo)Activity measurement

    In animals, thymogen changed the character of circadian motor activity rhythms.

    In plain wordsIn animals, thymogen changed daily rhythms of movement.

    Peptide
    Thymogen (oglufanide)
    Outcome
    Direction not reportedCircadian motor activity rhythms
    Study

    n: not reported in source

    Animals monitored in an open field
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    2 context sentences
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  10. 10AnimalAnimal study (in vivo)Activity measurement

    In animals, thymogen changed the dynamics of extinction of the orientation-investigation reaction.

    In plain wordsIn animals, thymogen changed how exploratory reactions faded.

    Peptide
    Thymogen (oglufanide)
    Outcome
    Direction not reportedExtinction of orientation-investigation reaction
    Study

    n: not reported in source

    Animals monitored in an open field
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    2 context sentences
    Summary · context
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  11. 11AnimalAnimal study (in vivo)Activity measurement

    In animals, thymogen ranked below nootropil and above T-activin in the reported activity ordering.

    In plain wordsIn animals, thymogen ranked below nootropil and above T-activin for activity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    Not applicableRelative neurotropic activity ranking
    Study

    n: not reported in source

    Animals monitored in an open field
    Comparator
    Other tested drugs
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    1 context sentence
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.
  12. 12AnimalAnimal study (in vivo)Activity measurement

    In animals, Cortexin ranked below ethymizol, cerebrolysin, thymalin, nootropil, thymogen and T-activin, but above dibazol for neurotropic activity.

    In plain wordsIn animals, Cortexin ranked below ethymizol, cerebrolysin, thymalin, nootropil, thymogen and T-activin, but above dibazol for activity.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedRelative neurotropic activity ranking
    Study

    n: not reported in source

    Animals assessed in an open field
    Comparator
    ethymizol, cerebrolysin, thymalin, nootropil, thymogen, T-activin and dibazol
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
    1 context sentence
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.

Studies that did not test the peptide alone3

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

  1. 13AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome

    In animals, the peptide immunomodulators showed neuromodulating effects comparable with known drugs, without a separate Cortexin estimate.

    In plain wordsIn animals, peptide immunomodulators showed effects comparable with known drugs. The abstract gives no separate Cortexin estimate.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedNeuromodulating effect
    Study

    n: not reported in source

    Animals assessed in an open field
    Comparator
    known drugs
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition

    Source sentences

    Summary
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  2. 14AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Mechanism

    In animals, the studied peptide immunomodulators changed motor-activity circadian rhythms, without a separate Cortexin estimate.

    In plain wordsIn animals, the studied peptide immunomodulators changed daily movement rhythms. The abstract gives no separate Cortexin estimate.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    MixedCircadian rhythms of motor activity
    Study

    n: not reported in source

    Animals assessed in an open field
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    1 context sentence
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  3. 15AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Mechanism

    In animals, peptide immunomodulators changed extinction dynamics of the orientation-investigation reaction, without a separate Cortexin estimate.

    In plain wordsIn animals, peptide immunomodulators changed how exploratory responses faded. The abstract gives no separate Cortexin estimate.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    MixedExtinction of orientation-investigation reaction
    Study

    n: not reported in source

    Animals assessed in an open field
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition

    Source sentences

    Summary
    They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction.
    1 context sentence
    Summary · context
    Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 5Current

    21 Oct 2026, 18:59 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 3

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 2

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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