Peptides / Skin and hair
Synthetic analog · 9 amino acids · 1,206.5 Da
Nonapeptide-1
Nonapeptide-1, also called Melanostatine-5, is a cosmetic peptide used in skin products marketed for uneven pigmentation, not an approved drug. On its own, it has been tested only in lab cells, on how it acts at the MC1 receptor. PepBank shows 8 results on nonapeptide-1 from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.
Also known as 153N-6, nonapeptide 1, Melanostatine 5, Melanostatine-5, White 05
9 amino acids, from first to lastMPFRWFKPV
Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.
Results in people
0
0% of 8 results
Results in animals
0
0% of 8 results
Results in lab cells
8
100% of 8 results
From computer models
0
0% of 8 results
Overview
Nonapeptide-1 at a glance
| What it is | Synthetic analog, 9 amino acids |
|---|---|
| Approval | Regulatory status not recorded |
| In sport | Status unknown |
| Studies | 3 studies with results. 1 of them gave nonapeptide-1, with 8 results. 8 in lab cells |
| Clinical trials | None registered |
| Community use | Topical cosmetic products marketed for uneven pigmentation |
The science
What is nonapeptide-1?
A cosmetic nonapeptide used in products marketed for uneven pigmentation.
9
Amino acids in one chain
Nonapeptide-1 structure and chemistry
The key facts about the molecule. Long codes are in the closed section below.
Sequence, 9 amino acidsFrom the first amino acid to the last
M1PF+RW5F+KPV
Darker means more water-repelling+ and − show charge in the bodyOutlined: changed amino acid
Structure
Nonapeptide-1 is a synthetic analog of 9 amino acids, with no ring, 3 changed amino acids.
Formula
C61H87N15O9S
Molecular weight
1,206.5 g/mol
CAS number
158563-45-2
Target
Melanocortin 1 receptor (gene MC1R): antagonist
Development
Highest phase: unknown.
Identifiers
PubChem 10418849, UNII 64W45420K5
Full sequence, SMILES and InChIKey
Three-letter sequenceMet-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
InChIKeyKNFLNGRLKALWRF-LDXSYGEZSA-N
SMILESCC(C)[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC5=CC=CC=C5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCSC)N
The evidence
What nonapeptide-1 studies show
Results grouped by what the studies measured. Each card shows where its results come from.
Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.
Key nonapeptide-1 studies
Studies in people come first, then studies in animals and in the lab.
- Lab cellsSynthesis of 153N-6 analogues and structure-function analysis at murine melanocortin-1 (MC1) receptors8 resultsSahm et al. 1999 · Peptides · cited by 5
Nonapeptide-1 clinical trials
ClinicalTrials.gov lists no trial of nonapeptide-1. A trial under another name may exist.
Status and safety
Is nonapeptide-1 approved?
FDA
United States
Status unknownStatus unknown.
EMA
European Union
Status unknownStatus unknown.
WADA
Sport
Not recordedStatus unknown.
Regulatory status not recorded. Status unknown.
Laws and labels change, so check the regulator for the current status.
Nonapeptide-1 side effects and safety
PepBank has no safety result from studies of nonapeptide-1 yet. That does not mean nonapeptide-1 is safe.
From the community
How people use it
What people report online. It comes from forums and guides, not from studies.
Community-reported. Not tested in trials.
The cited source reports this use. The report does not establish clinical efficacy or safety.
Reported routines and cautions
What people use it for
- Topical cosmetic products marketed for uneven pigmentationS1
Reported regimens
| Context | Route | Amount | How often | How long | Agreement | Sources |
|---|---|---|---|---|---|---|
| Topical cosmetic products marketed for uneven pigmentation | Not stated | 1 to 2 % per formulation | Not stated | Not stated | Single non-vendor guide. The page states no vendors and no affiliates. Its supplier concentration report was not independently confirmed. | S1 |
Community sources
Gaps
The source does not establish product identity, independent outcomes or a safe regimen.
Questions and more
Ask a question about nonapeptide-1
The answer links to every study it uses.
Sources
- Database: PepBank data for nonapeptide-1 (data version 308560)
- Regulator: FDA status record
- Regulator: EMA status record
- Regulator: WADA status record
- Community: community sources (forums and guides), as summarized in the PepBank community file
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
PepBank is a research reference. Talk to a doctor before you use any peptide.
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