Linaclotide studies: 66 papers with results
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Linaclotide has 251 linked papers. PepBank read up to 120 of the most-cited studies that gave it to people, up to 20 other studies, and the main trials.
- The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease.
Nanto-Hara F · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
Animal study (in vivo) · mouse · 12 results
- Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.
Grundy L · JCI insight · 2018
Animal study (in vivo) · mouse · 7 results
- Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine.
Ahsan MK · Physiological reports · 2017
Animal study (in vivo) · rat · 5 results
- Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk.
Ge P · Pain · 2019
Animal study (in vivo) · rat · 4 results
- Cyclic-GMP-Elevating Agents Suppress Polyposis in ApcMin mice by Targeting the Preneoplastic Epithelium.
Sharman SK · Cancer prevention research (Philadelphia, Pa.) · 2018
Animal study (in vivo) · mouse · 7 results
- Linaclotide improves gastrointestinal transit in cystic fibrosis mice by inhibiting sodium/hydrogen exchanger 3.
McHugh DR · American journal of physiology. Gastrointestinal and liver physiology · 2018
Animal study (in vivo) · mouse · 5 results
- Inhibition of Na+ /H+ exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator-deficient and F508del mutant mice.
Tan Q · British journal of pharmacology · 2021
Animal study (in vivo) · mouse · 6 results
- Intestinal neuropod cell GUCY2C regulates visceral pain.
Barton JR · The Journal of clinical investigation · 2023
Animal study (in vivo) · mouse · 4 results
- Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels.
Lucarini E · Pain · 2020
Animal study (in vivo) · rat · 1 result
- Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
Cil O · Translational research : the journal of laboratory and clinical medicine · 2017
Animal study (in vivo) · mouse · 2 results
- Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors.
Cuppoletti J · BMC pharmacology · 2012
Ex vivo tissue · pig · 8 results
- Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.
Pattison AM · Infection and immunity · 2016
Ex vivo tissue · mouse · 3 results
- MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux.
Tchernychev B · The Journal of pharmacology and experimental therapeutics · 2015
Ex vivo tissue · rat · 3 results
- Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity.
Motyka NI · Infection and immunity · 2021
In vitro (cells) · 1 result
- Improving the Gastrointestinal Stability of Linaclotide.
Braga Emidio N · Journal of medicinal chemistry · 2021
In vitro (cell-free) · 1 result
- Deciphering ion transporters, kinases and PDZ-adaptor molecules that mediate guanylate cyclase C agonist-dependent intestinal fluid loss in vivo.
Liu Y · Biochemical pharmacology · 2020
Not a test of Linaclotide alone · 2 results