Skip to content

Study · Ex vivo tissue · mouse · 2016

3 results

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.

Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA

Infection and immunity19 Sept 2016Cited by 28 (Europe PMC)

PMID27481254 (opens in a new tab)PMCIDPMC5038068 (opens in a new tab)DOI10.1128/iai.00639-16 (opens in a new tab)PepBankPUB-27481254
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In mouse intestinal enteroids, linaclotide induced luminal fluid accumulation.

    In plain wordsIn lab tests with mouse intestinal enteroids, linaclotide induced fluid accumulation.

    Peptide
    Linaclotide
    Outcome
    IncreaseEnteroid luminal fluid accumulation
    Study

    mousen: not reported in source

    three-dimensional intestinal enteroid cultures
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ST and its structural analog, linaclotide, an FDA-approved oral secretagog, induced fluid accumulation quantified simultaneously in scores of enteroid lumens, recapitulating ETEC-induced intestinal secretion.
    1 context sentence
    Summary · context
    Here, we reveal that mouse and human intestinal enteroids in three-dimensional ex vivo cultures express the components of the GUCY2C secretory signaling axis.
  2. 02LabEx vivo tissueActivity measurement

    In human intestinal enteroids, linaclotide induced luminal fluid accumulation.

    In plain wordsIn lab tests with human intestinal enteroids, linaclotide induced fluid accumulation.

    Peptide
    Linaclotide
    Outcome
    IncreaseEnteroid luminal fluid accumulation
    Study

    humann: not reported in source

    three-dimensional intestinal enteroid cultures
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ST and its structural analog, linaclotide, an FDA-approved oral secretagog, induced fluid accumulation quantified simultaneously in scores of enteroid lumens, recapitulating ETEC-induced intestinal secretion.
    1 context sentence
    Summary · context
    Here, we reveal that mouse and human intestinal enteroids in three-dimensional ex vivo cultures express the components of the GUCY2C secretory signaling axis.
  3. 03LabEx vivo tissueMechanism

    In intestinal enteroids, secretion depended on GUCY2C-produced cGMP, PKG activation, and CFTR opening.

    In plain wordsIn lab tests, enteroid secretion depended on GUCY2C, cGMP, PKG, and CFTR signaling.

    Peptide
    Linaclotide
    Outcome
    Not applicableSecretory signaling dependence
    Study

    n: not reported in source

    three-dimensional intestinal enteroid cultures
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Enteroid secretion depended on canonical molecular signaling events responsible for ETEC-induced diarrhea, including cyclic GMP (cGMP) produced by GUCY2C, activation of cGMP-dependent protein kinase (PKG), and opening of the cystic fibrosis transmembrane conductance regulator (CFTR).
    2 context sentences
    Summary · context
    ST and its structural analog, linaclotide, an FDA-approved oral secretagog, induced fluid accumulation quantified simultaneously in scores of enteroid lumens, recapitulating ETEC-induced intestinal secretion.
    Summary · context
    Here, we reveal that mouse and human intestinal enteroids in three-dimensional ex vivo cultures express the components of the GUCY2C secretory signaling axis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.