Trial · Interventional
RecruitingPhase 3Registry dataA Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting
Short name ACHIEVE-RAM
Overview
- Status
- Recruiting
- Phase
- Phase 3
- Enrollment
- 130 participants (estimated)
- Sponsor
- Eli Lilly and Company · Industry
- Design
- Allocation not applicable · Open label (no masking)
- Countries
4 countries
India, Saudi Arabia, South Africa, United Arab Emirates
- Start
- 15 Jul 2026
- Primary completion
- May 2027 (estimated)
- Completion
- May 2027 (estimated)
- First posted
- 29 May 2026
- Last update posted
- 8 Oct 2026
- Conditions
- Diabetes Mellitus, Type 2 · Diabetes Melletus · Glucose Metabolism Disorders · Metabolic Disorders · Nutritional and Metabolic Diseases · Endocrine System Diseases · Feeding Behavior · Behavior · Fasting · Glucagon-Like Peptide-1 Receptor · Glucagon-Like Peptide Receptors · Receptors, G-Protein-Coupled · Receptors, Cell Surface · Membrane Proteins · Proteins · Receptors, Peptide
Timeline
1 trial · 1 ongoing
- Completed
- Ongoing
- Not yet recruiting
- Stopped
- Estimated dates (est.)
- Results posted
- Ph 3
Registry summary
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
The purpose of this study is to test the efficacy and safety of orforglipron in participants with T2D (type 2 diabetes) who participate in fasting during Ramadan. For each participant, the study will last up to 48 weeks with a minimum of 7 in clinic visits and 4 virtual visits.
Interventions
- OrforglipronDrug
Arms1
Experimental
Orforglipron
Administered orally
Primary outcomes1
Outcomes the sponsor listed as primary.
Change from Baseline in Hemoglobin A1C (HbA1c)
Time frame · Baseline, up to 8 Weeks after Start of Ramadan
Secondary outcomes(6)
Percentage of Participants with an HbA1c of less than (<) 7 Percent (%) (53 millimeters per mole (mmol/mol))
Time frame · Baseline, Up to 8 Weeks after Start of Ramadan
Change From Baseline in Fasting Serum Glucose (FSG)
Time frame · Baseline, Up to 8 Weeks after Start of Ramadan
Percent Change from Baseline in Body Weight
Time frame · Baseline, Up to 8 Weeks after Start of Ramadan
Change in EuroQol 5-Dimension 5-Level (EQ-5D-5L) Index
Time frame · Baseline, Up to 8 Weeks after Start of Ramadan
Percent Change in HbA1c
Time frame · 4 Weeks Prior to Ramadan, Up to Week 8 after Start of Ramadan]
Percent Change in Body Weight
Time frame · 4 Weeks Prior to Ramadan, Up to Week 8 after Start of Ramadan]
Posted results
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
A trial that is still running, or that stopped early, may post results later.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies0
Studies that cite this trial.
No study cites this trial.
Eligibility
Who could join, as posted.
- Sex
- All
- Age
- from 18 Years up to 65 Years
- Healthy volunteers
- Not accepted
Inclusion and exclusion criteria, as posted
PepBank is a research reference. Talk to a doctor before you use any peptide.