Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity in the Real World

Measured as months Participants who were diagnosed of MI (identified using International Classification of Disease, 10th Edition, Clinical Modification \[ICD-10-CM\] diagnosis codes) observed during an inpatient (IP) visit. The event date will be admission date of the IP visit.

Measured as months Participants who were diagnosed of stroke, including both ischemic and hemorrhagic, (identified using ICD-10- CM diagnosis codes) which was observed during an IP visit. The event date will be the admission date of the IP visit.

Measured as months Participants who were diagnosed of HF (identified using ICD-10-CM diagnosis codes) observed during an IP visit. The event date will be the first observed admission date of the IP visit.

Measured as months Participants with evidence of coronary revascularization in any claim (identified using ICD-10-PCS, Current Procedural Terminology \[CPT\], or Healthcare Common Procedure Coding System \[HCPCS\] procedure codes). The event date will be the first observed date of coronary revascularization.

Measured as months Participants with evidence of death as recorded at the month and year level in KRD and defined as a death record observed within the last month of follow-up. The event date will be the earliest of the end of follow-up (e.g., bariatric surgery within the month of death and last month of follow-up) or the last day of the recorded month of death.

Measured as months Occurrence of any of the following individual component events: 1. MI 2. Stroke 3. Hospitalization for HF 4. Coronary revascularization 5. CV-related mortality The event date will be the earliest occurrence of one of the individual components.

Measured as months Occurrence of any of the following individual component events: 1. MI 2. Stroke 3. CV-related mortality The event date will be the earliest occurrence of one of the individual components.

Measured as months Partcipants with any claim within ≤30 days before the date of death (i.e., the last day of the recorded month of death, where death is observed in the last month of follow-up) of the following operational definition to indicate a CV-related mortality (identified using ICD-10-CM diagnosis codes): (1) A primary diagnosis of MI (2) A primary diagnosis of ischemic or hemorrhagic stroke (3) A primary diagnosis of HF (4) Evidence of peripheral arterial revascularization, coronary revascularization, CABG, PCI, or carotid intervention in any claim (identified using ICD-10-PCS, CPT, or HCPCS procedure codes). (5) A primary diagnosis of CV hemorrhage (excluding hemorrhagic stroke) (6) A primary diagnosis of other CV conditions including unstable angina, sudden cardiac arrest, cardiogenic shock, and other cerebrovascular and CV events. The event date will be the earliest of the end of follow-up (e.g., bariatric surgery within the month of death) or the date of death.