Evaluation of Gastric Content of Volunteers Fasting and Using Semaglutide: an Observational and Cross-sectional Study

Status

Completed

Phase

Phase not stated

Enrollment

30 participants (actual)

Sponsor

Hospital Israelita Albert Einstein · Other

Design

Not stated

Countries

1 country

Brazil

Start

19 Jun 2023

Primary completion

19 Jun 2023

Completion

22 Aug 2023

First posted

4 Dec 2023

Last update posted

4 Dec 2023

Conditions

Pneumonia, Aspiration · Anesthesia

Medicines with peptide-1 receptor agonist action similar to glucagon (GLP-1) are a modern therapeutic option for obesity and diabetes mellitus. Semaglutide is a representative of this class medication whose mechanism of action can result in the slowing of gastric emptying and reduced gastric motility, a scenario that can increase the risk of pulmonary aspiration in individuals undergoing anesthesia and despite adequate fasting. Given the severity of the occurrence of bronchoaspiration, the action biological analysis of GLP-1 analogues on gastric function and incremental use of these medications, through gastric ultrasound, we will aim to evaluate the gastric contents of volunteers who do not have risk factors for bronchoaspiration, who will not undergo anesthesia, but are with the fasting recommended for this purpose and are using semaglutide, an analogue of GLP-1. Our hypothesis is that the majority of individuals using these medications have a full stomach even during fasting times recommended in the literature. In view of this, for this population we must adapt safety criteria during the anesthetic procedure.

• Other

  semaglutide group

  patients without risk factors for gastroparesis, fasting for at least 8 hours, BMI less than 30 and currently using semaglutide

• Other

  control group

  patients without risk factors for gastroparesis, fasting for at least 8 hours, BMI less than 30 and who have never used semaglutide or another GLP-1 analogue

1. prevalence of full stomach after fasting for at least 8 hours

   Time frame · 1 day

   Registry description

   Compare the prevalence of a full stomach, after fasting for at least 8 hours for solids and 2 hours for clear liquids, through gastric ultrasound in volunteers using semaglutide with those who do not use the medication. The outcome will be binary: a full stomach includes the visualization of solids on gastric ultrasonography or a volume of clear liquids greater than 1.5ml/kg. It will be considered an empty stomach when no content or clear liquids are visible inferior to 1.5ml/kg.