Trial · Interventional
CompletedNot applicableRegistry dataEffect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity
Overview
- Status
- Completed
- Phase
- Not applicable
- Enrollment
- 131 participants (actual)
- Sponsor
- Seneque SA · Industry
- Design
- Randomized · Quadruple masking
- Countries
1 country
France
- Start
- 9 Mar 2021
- Primary completion
- 10 Nov 2022
- Completion
- 30 May 2023
- First posted
- 11 Dec 2020
- Last update posted
- 17 Jan 2024
- Conditions
- Physical Activity · Muscle Recovery
Timeline
1 trial · 1 completed
- Completed
- Ongoing
- Not yet recruiting
- Stopped
- Estimated dates (est.)
- Results posted
- N/A
Effect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity
NCT046643619 Mar 2021 to 30 May 2023
Registry summary
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
The purpose of this study is to evaluate the effect of NMN supplementation (250 and 500 mg/day over 38 days) compared to placebo in healthy volunteers with moderate physical activity on muscle recovery, physical capacity, cardiorespiratory recovery, the perception of the arduousness of the effort, the variation in blood lactate levels before and after physical exercise, the perception of the intensity of post-exercise muscle pain (cramps), the body composition and Nicotinamide-Adenine Mononucleotide (NAD+) level in blood.
Interventions
- Nicotinamide mononucleotideDietary supplement
- PlaceboOther
Arms3
Experimental
NMN 250
NMN tablet (250 mg)
Experimental
NMN 500
NMN tablet (500 mg)
Placebo comparator
Placebo
NMN-free placebo tablet.
Primary outcomes1
Outcomes the sponsor listed as primary.
Evolution of muscle recovery
Time frame · before and after 21 and 38 days of treatment
Registry description
Wingate Anaerobic Test (WANT) preformed post-endurance test (at 85% maximum aerobic speed)
Secondary outcomes(7)
Changes in physical capacity
Time frame · before and after 21 and 38 days of treatment
Registry description
physical capacity evaluated during an endurance test (at 85% maximum aerobic speed) by the maximum duration (time limit)
Changes in cardiorespiratory recovery
Time frame · before and after 21 and 38 days of treatment
Registry description
Measurement of blood pressure and heart rate at rest and at intervals of several minutes after the endurance test (at 85% maximum aerobic speed)
Changes in the perception of the arduousness of the effort
Time frame · before and after 21 and 38 days of treatment
Registry description
evaluated by the Borg scale during the endurance test (at 85% maximum aerobic speed)
Changes in blood lactate levels before and after physical exercise
Time frame · before and after 21 and 38 days of treatment
Registry description
blood lactate levels before and after the endurance test (at 85% maximum aerobic speed)
Changes in the perception of the intensity of post-exercise muscle pain (cramps)
Time frame · before and after 21 and 38 days of treatment
Registry description
post-exercise muscular pain in evaluated using a 7 points numerical scale, 24, 48 and 72 hours after the endurance test
Changes in the body composition
Time frame · before and after 21 and 38 days of treatment
Registry description
fat mass, muscle mass, visceral fat, water mass determined by Bioelectrical Impedance Analysis (BIA)
Changes blood NAD+ levels
Time frame · before and after 21 and 38 days of treatment
Registry description
Evaluation of cellular NAD+ concentration in blood from baseline to the end of study
Posted results
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
Completed trials do not always post results.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies0
Studies that cite this trial.
No study cites this trial.
Eligibility
Who could join, as posted.
- Sex
- Male
- Age
- from 20 Years up to 49 Years
- Healthy volunteers
- Accepted
Inclusion and exclusion criteria, as posted
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