Pasireotide Therapy in Patients With Nelson's Syndrome

Status

Terminated

Phase

Phase 2

Enrollment

8 participants (actual)

Sponsor

Sheffield Teaching Hospitals NHS Foundation Trust · Other

Design

Allocation not applicable · Open label (no masking)

Countries

1 country

United Kingdom

Start

Mar 2011

Primary completion

Aug 2015

Completion

Dec 2015

First posted

12 Jun 2012 (estimated)

Last update posted

2 Nov 2016 (estimated)

Conditions

Nelson Syndrome

Nelson's syndrome, an expanding pituitary tumour, occurs in up to 30% of adults after bilateral adrenalectomy for Cushing's disease, for which no medical treatment exists. Plasma Adrenocorticotrophic hormone (ACTH) levels in these patients remain high, they are characteristically deeply pigmented, and may experience neurological effects as a consequence of the tumour. It is not known whether the tumour growth is due to the lack of cortisol feedback after adrenalectomy or whether the pituitary cells were preprogrammed to develop into a tumour. There is a real need for an effective medical management for Nelson's syndrome. This is especially true given the increasing data on the somewhat disappointing longterm outcome of transsphenoidal surgery, and the increasing use of aparoscopic bilateral adrenalectomy for failures of pituitary surgery or even as primary therapy for Cushing's disease. Therefore, it is likely that there will be increasing numbers of patients attending endocrine centres worldwide with Nelson's syndrome following bilateral adrenalectomy as part of their management for Cushing's disease. In view of this it is important to investigate all potential avenues for the treatment of Nelson's syndrome and translate any benefits to patients. This study, designed and initiated by the investigators, will assess if pasireotide reduces ACTH levels and tumour volume in patients with Nelson's syndrome. Patients will be recruited for a period of 32 weeks and receive 4 weeks of pasireotide twice daily and then 24 weeks of pasireotide long acting release therapy every 4 weeks. Over the 32 week protocol patients will make 12 visits for serial ACTH blood measurements and have 2 MRI scans to assess tumour volume.

• Experimental

  Pasireotide

  4 Weeks pasireotide 0.6mg s/c injections twice daily followed by 24 weeks treatment with pasireotide LAR 60mg every 28 days with dose reductions if poor tolerability is encountered

1. Serum ACTH levels in patients with Nelson's syndrome.

   Time frame · 0, 2, 4, 8, 12, 16, 20, 24, 28 weeks

   Registry description

   Early morning plasma ACTH sampled at 0, 1, 2, and 3 hours after morning hydrocortisone (HC) during 4 weeks of pasireotide 1200ug/day compared with levels at these respective time points found at baseline, and after chronic depot pasireotide 60mg i.m every 28 days: Complete success: Fall in pre-HC plasma ACTH \> 400ng/l, or 120 minutes after HC \>200ng/l Partial success: Fall in pre-HC plasma ACTH \< 399ng/l \>200ng/l, or 120 minutes after HC \<199ng/l \>100ng/l No success: Fall in pre-HC plasma ACTH \< 199ng/l, or 120 minutes after HC \<99ng/l