Role of Oxytocin in Post-menopausal Osteoporosis: Evaluation on the Population of the OPUS Cohort

Status

Completed

Phase

Phase not stated

Enrollment

1,000 participants (actual)

Sponsor

Centre Hospitalier Universitaire de Nice · Other

Design

Not stated

Countries

1 country

France

Start

Jul 2011

Primary completion

Oct 2011

Completion

Oct 2013

First posted

1 Sept 2010 (estimated)

Last update posted

14 Aug 2015 (estimated)

Conditions

Osteoporosis

Oxytocin is a neurohypophysial hormone involved in several central and peripheral functions including parturition, milk let-down reflex and social behaviour. In vitro and animals studies have shown growing evidence that oxytocin plays a role in bone remodeling and osteoporosis. The investigators have previously show in a small sample of post-menopausal women with severe osteoporosis (n=20) compare to healthy control (n=16) that oxytocin serum level is significantly decreased, independently of leptin and estradiol, that are known to modulate oxytocin secretion. Thus, oxytocin appears as a new interesting factor in the osteoporosis pathophysiology. The aim of the present study is to confirm the relationships between bone status, evaluated by bone mineral density and prevalent fragility fractures, body composition and oxytocin serum levels on a large population. The investigators will also determine if the relationship between bone mineral density and oxytocin is independent of estradiol and leptin in this population and evaluate the relationships between oxytocin serum level and co-morbidities such as cardiovascular diseases, depression and dementia. Theses analysis will be done on the serum already available of 1000 women of the international OPUS cohort. Bone mineral density, body composition analysis by Dual energy X-ray Absorptiometry (DXA), estradiol and clinical data are already available. The investigators will select women, aged from 55 to 79 y at the time of inclusion.

• Other

  OPUS

  OPUS is a prospective study of postmenopausal women recruited in the general population between April 1999 and April 2001 from five European centers (Aberdeen (UK), Berlin (Germany), Kiel (Germany), Paris (Hospital Cochin, France), and Sheffield (UK)). Investigations were approved at each institution according to the Declaration of Helsinki. Written consent was obtained from all subjects. Each center recruited approximately 500 postmenopausal women comprising 100 individuals in each 5-yr age band between 55 and 79. Ninety-nine percent of subjects were of white ethnicity.

1. oxytocin serum levels

   Time frame · at time = 0

   Registry description

   oxytocin serum levels, measured by radio-immuno assay, at the spine and the hip in post-menopausal women

2. bone mineral density

   Time frame · at time = 0

   Registry description

   bone mineral density, measured by dual X ray absorptiometry at the spine and the hip in post-menopausal women