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Study · Measured the body's own peptide · 2014

8 results

Oxytocin, a new determinant of bone mineral density in post-menopausal women: analysis of the OPUS cohort.

Breuil V, Panaia-Ferrari P, Fontas E, Roux C, Kolta S, Eastell R, Ben Yahia H, Faure S, Gossiel F, Benhamou CL, Euller-Ziegler L, Amri EZ

The Journal of clinical endocrinology and metabolism21 Jan 2014Cited by 37 (Europe PMC)

PMID24446658 (opens in a new tab)DOI10.1210/jc.2013-4126 (opens in a new tab)PepBankPUB-24446658
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, higher natural serum oxytocin levels were positively correlated with spine bone mineral density (r = +0.12).

    In plain wordsIn postmenopausal women, higher natural oxytocin levels in the body were linked to higher spine bone density.

    Peptide
    Oxytocin
    Outcome
    IncreaseSerum oxytocin and spine bone mineral density
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    Correlation coefficient r
    0.12
    spine BMD

    Source sentences

    Summary
    The OT serum level was related to spine (r = +0.12, P = .0002)
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, higher natural serum oxytocin levels were positively correlated with total hip bone mineral density (r = +0.21).

    In plain wordsIn postmenopausal women, higher natural oxytocin levels in the body were linked to higher hip bone density.

    Peptide
    Oxytocin
    Outcome
    IncreaseSerum oxytocin and total hip bone mineral density
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    Correlation coefficient r
    0.21
    total hip BMD

    Source sentences

    Summary
    The OT serum level was related to spine (r = +0.12, P = .0002) and total hip BMD (r = +0.21, P < .0001)
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, natural serum oxytocin levels were negatively correlated with the bone turnover marker procollagen type 1 N-terminal propeptide (r = -0.13).

    In plain wordsIn postmenopausal women, higher natural oxytocin levels in the body were linked to lower levels of a bone formation marker.

    Peptide
    Oxytocin
    Outcome
    DecreaseSerum oxytocin and procollagen type 1 N-terminal propeptide
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    Correlation coefficient r
    −0.13
    procollagen type 1 N-terminal propeptide

    Source sentences

    Summary
    The OT serum level was related to spine (r = +0.12, P = .0002) and total hip BMD (r = +0.21, P < .0001) and with BTM (procollagen type 1 N-terminal propeptide: r = -0.13, P < .0001, bone alkaline phosphatase: r = -0.07, P = .02, C-telopeptide of type 1 collagen: r = -0.18, P < .0001).
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, natural serum oxytocin levels were negatively correlated with the bone turnover marker bone alkaline phosphatase (r = -0.07).

    In plain wordsIn postmenopausal women, higher natural oxytocin levels in the body were linked to lower levels of a bone turnover marker.

    Peptide
    Oxytocin
    Outcome
    DecreaseSerum oxytocin and bone alkaline phosphatase
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    Correlation coefficient r
    −0.07
    bone alkaline phosphatase

    Source sentences

    Summary
    The OT serum level was related to spine (r = +0.12, P = .0002) and total hip BMD (r = +0.21, P < .0001) and with BTM (procollagen type 1 N-terminal propeptide: r = -0.13, P < .0001, bone alkaline phosphatase: r = -0.07, P = .02, C-telopeptide of type 1 collagen: r = -0.18, P < .0001).
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, natural serum oxytocin levels were negatively correlated with the bone turnover marker C-telopeptide of type 1 collagen (r = -0.18).

    In plain wordsIn postmenopausal women, higher natural oxytocin levels in the body were linked to lower levels of a bone breakdown marker.

    Peptide
    Oxytocin
    Outcome
    DecreaseSerum oxytocin and C-telopeptide of type 1 collagen
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    Correlation coefficient r
    −0.18
    C-telopeptide of type 1 collagen

    Source sentences

    Summary
    The OT serum level was related to spine (r = +0.12, P = .0002) and total hip BMD (r = +0.21, P < .0001) and with BTM (procollagen type 1 N-terminal propeptide: r = -0.13, P < .0001, bone alkaline phosphatase: r = -0.07, P = .02, C-telopeptide of type 1 collagen: r = -0.18, P < .0001).
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, natural serum oxytocin levels had no significant relationship with fractures.

    In plain wordsIn postmenopausal women, natural oxytocin levels in the body were not linked to fractures.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin and fractures
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    There was no significant relationship between OT serum levels and fractures.
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelObservational studyOther

    In 1097 postmenopausal women, the relationship of natural serum oxytocin with bone mineral density was independent of bone turnover markers.

    In plain wordsIn postmenopausal women, the link between the body's own oxytocin and bone density held even when bone turnover markers were taken into account.

    Peptide
    Oxytocin
    Outcome
    IncreaseRelationship of serum oxytocin with bone mineral density independent of bone turnover markers
    Study

    n = 1,097

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The relationship of OT with BMD was independent of BTM.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelObservational studyOther

    In postmenopausal women with unmeasurable estradiol or leptin above the median, the correlation between natural serum oxytocin and bone mineral density stayed significant at the hip after adjustment.

    In plain wordsIn some postmenopausal women, higher natural oxytocin levels stayed linked to higher hip bone density after adjustment for other factors.

    Peptide
    Oxytocin
    Outcome
    IncreaseSerum oxytocin and hip bone mineral density after adjustment, in women with unmeasurable estradiol or high leptin
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    After adjustment for confounding factors, the correlation between OT serum level and BMD remains significant at the hip in women with unmeasurable estradiol or leptin above the median value.
    1 context sentence
    Summary · context
    OT, leptin, and estradiol serum levels were measured in 1097 postmenopausal women and compared with bone mineral density (BMD), fractures, and the bone turnover markers (BTMs) procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, and C-telopeptide of type 1 collagen.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase not statedNCT01192893

Role of Oxytocin in Post-menopausal Osteoporosis: Evaluation on the Population of the OPUS Cohort

Centre Hospitalier Universitaire de Nicen = 1,000Jul 2011 to Oct 2013

Osteoporosis

Trial pageClinicalTrials.govUpdated 14 Aug 2015

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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