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Trial · Interventional

CompletedNot applicableRegistry data

Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients

NCTNCT00635440 (opens ClinicalTrials.gov in a new tab)Other idMuscle-2446
Open at ClinicalTrials.govAsk about this trial

This trial does not test a peptide that PepBank tracks.

  • Names IGF-1 (mecasermin), does not test it. It appears in the conditions.

Overview

Status
Completed
Phase
Not applicable
Enrollment
26 participants (actual)
Sponsor
Medical University of Vienna · Other
Design
Randomized · Single masking
Countries
1 country

Austria

Start
Dec 2005
Primary completion
Not stated
Completion
Not stated
First posted
13 Mar 2008 (estimated)
Last update posted
13 Mar 2008 (estimated)
Conditions
Muscular Atrophy

Timeline

1 trial · 1 completed

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
20052006
  1. N/A

    Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients

    NCT00635440

    Start Dec 2005

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.

Interventions

  • neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)Device
  • neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)Device

Arms2

  • Active comparator

    A

  • Sham comparator

    B

Primary outcomes1

Outcomes the sponsor listed as primary.

  1. mRNA level of IGF-1Ea

Secondary outcomes(1)

  1. mRNA level of MGF, total RNA content, total protein content, ubiquitin conjugated proteins, proteasome activity

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

Completed trials do not always post results.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies2

Studies that cite this trial.

Studies with results

2 studies on this page

Indexing hint: Randomized controlled trial · 2009

2 results

Neuromuscular electrical stimulation reduces skeletal muscle protein degradation and stimulates insulin-like growth factors in an age- and current-dependent manner: a randomized, controlled clinical trial in major abdominal surgical patients.

Strasser et al. 2009Annals of surgerycited by 44

PMID 19387331DOI 10.1097/sla.0b013e3181a38e71PUB-19387331

Full text at the publisher2 results
Publisher pageSee results (2)

Indexing hint: Observational study · 2003

4 results

Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise.

Hameed et al. 2003The Journal of physiologycited by 274

PMID 12562960DOI 10.1113/jphysiol.2002.032136PUB-12562960

Full text at the publisher4 results
Publisher pageSee results (4)

Eligibility

Who could join, as posted.

Sex
All
Age
from 18 Years
Healthy volunteers
Not accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria: * intended for major abdominal surgery * more than 18 years old Exclusion Criteria: * neuromuscular diseases * immobility before surgery * arterial occlusive disease Fontaine stadium IV * clinical or laboratory signs of inflammation or sepsis * cachexia * diseases of the musculoskeletal systems contraindicating electrical stimulation

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