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Trial · Interventional

CompletedNot applicableRegistry data

Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content

NCTNCT00476879 (opens ClinicalTrials.gov in a new tab)Other id090600-deleted
Open at ClinicalTrials.govAsk about this trial

Overview

Status
Completed
Phase
Not applicable
Enrollment
10 participants (actual)
Sponsor
University of Aarhus · Other
Design
Randomized · Open label (no masking)
Countries
1 country

Denmark

Start
Aug 2006
Primary completion
Nov 2007
Completion
Jun 2008
First posted
22 May 2007 (estimated)
Last update posted
12 Aug 2008 (estimated)
Conditions
Metabolism · Fatty Liver

Timeline

1 trial · 1 completed

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
2006200720082009
  1. N/A

    Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content

    NCT00476879

    Aug 2006 to Jun 2008

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.

Interventions

  • Somatropin and pegvisomantDrug

Arms4

  • Experimental

    1

    12 hours of fasting and a GH bolus

  • Experimental

    2

    36 hours of fasting and a GH bolus

  • Experimental

    3

    36 hours of fasting and Pegvisomant

  • Experimental

    4

    36 hours of fasting and NaCl injection

Primary outcomes6

Outcomes the sponsor listed as primary.

  1. changes in intrahepatic lipid content

    Time frame · 12 and 36 hours of fasting. respectively

  2. changes in intracellular signaling during fasting

    Time frame · 36 hours

  3. changes in respiratory quotient

    Time frame · 36 hours of fasting

  4. metabolism

    Time frame · 36 hours of fasting

  5. insulin sensitivity

    Time frame · 36 hours of fasting

  6. forearm metabolism

    Time frame · 36 hours of fasting

Secondary outcomes(3)

  1. changes in FFA

    Time frame · 36 hours of fasting

  2. Changes in grelin

    Time frame · 36 hours of fasting

  3. changes in leptin, adiponektin, cortisol, catecholamine, glucagon, carbamide, palmitate

    Time frame · 36 hours of fasting

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

Completed trials do not always post results.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies1

Studies that cite this trial.

Studies with results

1 study on this page

Indexing hint: Randomized controlled trial · 2009

10 results

Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.

Moller et al. 2009The Journal of clinical endocrinology and metabolismcited by 31

PMID 19820031PMC2775657DOI 10.1210/jc.2009-0381PUB-19820031

Rights unknown10 results
Source linkSee results (10)

Eligibility

Who could join, as posted.

Sex
Male
Age
from 20 Years up to 40 Years
Healthy volunteers
Accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria: * male * healthy * age 20 - 40 years of age * BMI 20 -25 Exclusion Criteria: * uses any medication * drinks more than 21 units of alcohol per * is claustrophobic * carries any magnetic devices

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