RF34 | PMON222 Reproductive Hormone Secretion is Increased by Intranasal Kisspeptin in Humans

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Journal of the Endocrine Society1 Nov 2022

PMCIDPMC9625162PepBankPUB-99856002

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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 13 results from people.

01HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 raised mean LH dose-dependently at 3.2-12.8 nmol/kg versus saline.
In plain wordsIn healthy men, kisspeptin sprayed into the nose raised luteinising hormone more than saline, and a higher dose gave a larger rise.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH level in healthy men
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3.2-12.8 nmol/kg · intranasalAs given in this study (human).
Source sentences
Summary
In healthy men, intranasal kisspeptin dose-dependently increased mean luteinising hormone (LH) levels at doses between 3.2-12.8 nmol/kg (p=0.008 and <0.0001 for 6.4 and 12.8 nmol/kg vs saline, respectively), with the maximal rises occurring at 30-45 minutes post-administration.
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600201
02HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 at 3.2 nmol/kg raised the area under the curve for LH change versus saline.
In plain wordsIn healthy men, a nasal kisspeptin dose raised the total luteinising hormone change more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH change AUC in healthy men, 3.2 nmol/kg
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3.2 nmol/kg · intranasalAs given in this study (human).
Measurements
LH change AUC
172.2 h.IU/L
3.2 nmol/kg
Source sentences
Summary
Correspondingly, the area under the curve (AUC) for the LH change was significantly elevated following all doses of kisspeptin compared to saline (saline: -25.4±70.5 h.IU/L; 3.2 nmol/kg: 172.2±64.2 h.IU/L [p=0.03]; 6.4 nmol/kg: 300.2±79.2 h.IU/L [p=0.002]; 12.8 nmol/kg: 595.7±98.3 h.IU/L [p=0.001];…
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600202
03HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 at 6.4 nmol/kg raised the area under the curve for LH change versus saline.
In plain wordsIn healthy men, a nasal kisspeptin dose raised the total luteinising hormone change more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH change AUC in healthy men, 6.4 nmol/kg
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
6.4 nmol/kg · intranasalAs given in this study (human).
Measurements
LH change AUC
300.2 h.IU/L
6.4 nmol/kg
Source sentences
Summary
Correspondingly, the area under the curve (AUC) for the LH change was significantly elevated following all doses of kisspeptin compared to saline (saline: -25.4±70.5 h.IU/L; 3.2 nmol/kg: 172.2±64.2 h.IU/L [p=0.03]; 6.4 nmol/kg: 300.2±79.2 h.IU/L [p=0.002]; 12.8 nmol/kg: 595.7±98.3 h.IU/L [p=0.001];…
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600203
04HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 at 12.8 nmol/kg raised the area under the curve for LH change versus saline.
In plain wordsIn healthy men, a nasal kisspeptin dose raised the total luteinising hormone change more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH change AUC in healthy men, 12.8 nmol/kg
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
12.8 nmol/kg · intranasalAs given in this study (human).
Measurements
LH change AUC
595.7 h.IU/L
12.8 nmol/kg
Source sentences
Summary
Correspondingly, the area under the curve (AUC) for the LH change was significantly elevated following all doses of kisspeptin compared to saline (saline: -25.4±70.5 h.IU/L; 3.2 nmol/kg: 172.2±64.2 h.IU/L [p=0.03]; 6.4 nmol/kg: 300.2±79.2 h.IU/L [p=0.002]; 12.8 nmol/kg: 595.7±98.3 h.IU/L [p=0.001];…
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600204
05HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 at 25.6 nmol/kg raised the area under the curve for LH change versus saline.
In plain wordsIn healthy men, a nasal kisspeptin dose raised the total luteinising hormone change more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH change AUC in healthy men, 25.6 nmol/kg
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
25.6 nmol/kg · intranasalAs given in this study (human).
Measurements
LH change AUC
549 h.IU/L
25.6 nmol/kg
Source sentences
Summary
Correspondingly, the area under the curve (AUC) for the LH change was significantly elevated following all doses of kisspeptin compared to saline (saline: -25.4±70.5 h.IU/L; 3.2 nmol/kg: 172.2±64.2 h.IU/L [p=0.03]; 6.4 nmol/kg: 300.2±79.2 h.IU/L [p=0.002]; 12.8 nmol/kg: 595.7±98.3 h.IU/L [p=0.001];…
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600205
06HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 raised FSH with a time course similar to LH.
In plain wordsIn healthy men, kisspeptin sprayed into the nose raised follicle stimulating hormone in a pattern similar to luteinising hormone.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseFSH level in healthy men
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
Follicle stimulating hormone (FSH) levels followed a similar trajectory to LH in response to intranasal kisspeptin.
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600206
07HumanRandomized controlled trialEfficacy outcome
In healthy men, intranasal kisspeptin‑54 at 12.8 nmol/kg raised serum testosterone from 120 minutes onwards versus saline.
In plain wordsIn healthy men, a nasal kisspeptin dose raised testosterone from 120 minutes onwards compared with saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseSerum testosterone in healthy men
Study
n = 12
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
12.8 nmol/kg · intranasalAs given in this study (human).
Measurements
Maximal testosterone change from baseline
4.9 nmol/L
12.8 nmol/kg
Source sentences
Summary
Moreover, kisspeptin at 12.8 nmol/kg increased serum testosterone from 120 minutes onwards (p=0.02), with a maximal change from baseline of 4.9±0.7 nmol/L (p=0.03).
2 context sentences(design, population, supporting numbers)
Summary · context
Randomised, double-blinded, placebo-controlled, cross-over study in 12 healthy men (mean±SEM age 28.3±1.7 yrs; BMI 24.5±0.7 kg/m2).
Summary · context
After monitored self-administration of intranasal kisspeptin-54 (3.2, 6.4, 12.8 and 25.6 nmol/kg) or 0.9% saline, serum reproductive hormone levels were measured every 15 minutes for four hours.
Report a problemFND-9985600207
08HumanNon-randomized trialEfficacy outcome
In women with hypothalamic amenorrhoea, intranasal kisspeptin‑54 raised mean LH versus saline.
In plain wordsIn women with hypothalamic amenorrhoea, kisspeptin sprayed into the nose raised luteinising hormone more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMean LH in women with hypothalamic amenorrhoea
Study
n = 4
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
12.8 nmol/kg · intranasalAs given in this study (human).
Source sentences
Summary
In women with HA, intranasal kisspeptin increased mean LH (p=0.002 vs saline), with the peak levels occurring at 30-45 minutes post-administration.
1 context sentence(design, population, supporting numbers)
Summary · context
Subsequently, four women (mean age 29.8±3.7 yrs; BMI 21.2±1.1 kg/m2) with hypothalamic amenorrhoea (HA) attended for the same protocol comparing intranasal kisspeptin-54 (12.8 nmol/kg) and 0.9% saline.
Report a problemFND-9985600208
09HumanNon-randomized trialEfficacy outcome
In women with hypothalamic amenorrhoea, intranasal kisspeptin‑54 raised the area under the curve for LH change versus saline.
In plain wordsIn women with hypothalamic amenorrhoea, nasal kisspeptin raised the total luteinising hormone change more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH change AUC in women with hypothalamic amenorrhoea
Study
n = 4
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
12.8 nmol/kg · intranasalAs given in this study (human).
Measurements
LH change AUC
508.4 h.IU/L
kisspeptin-54 12.8 nmol/kg
Source sentences
Summary
The AUC for the LH change was 508.4±77.5 h.IU/L (p=0.02 vs saline AUC for LH).
1 context sentence(design, population, supporting numbers)
Summary · context
Subsequently, four women (mean age 29.8±3.7 yrs; BMI 21.2±1.1 kg/m2) with hypothalamic amenorrhoea (HA) attended for the same protocol comparing intranasal kisspeptin-54 (12.8 nmol/kg) and 0.9% saline.
Report a problemFND-9985600209
10HumanNon-randomized trialEfficacy outcome
In women with hypothalamic amenorrhoea, the maximal LH change from baseline was larger with intranasal kisspeptin‑54 than with saline.
In plain wordsIn women with hypothalamic amenorrhoea, nasal kisspeptin gave a larger peak rise in luteinising hormone than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMaximal LH change from baseline in women with hypothalamic amenorrhoea
Study
n = 4
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
12.8 nmol/kg · intranasalAs given in this study (human).
Measurements
Maximal LH change
4.1 IU/L
kisspeptin-54
Maximal LH change
0.2 IU/L
saline
Source sentences
Summary
The maximal LH change from baseline was 4.1±0.9 IU/L compared to 0.2±0.4 IU/L for saline (p=0.03).
1 context sentence(design, population, supporting numbers)
Summary · context
Subsequently, four women (mean age 29.8±3.7 yrs; BMI 21.2±1.1 kg/m2) with hypothalamic amenorrhoea (HA) attended for the same protocol comparing intranasal kisspeptin-54 (12.8 nmol/kg) and 0.9% saline.
Report a problemFND-9985600210
11HumanNon-randomized trialEfficacy outcome
In women with hypothalamic amenorrhoea, intranasal kisspeptin‑54 raised mean FSH versus saline.
In plain wordsIn women with hypothalamic amenorrhoea, kisspeptin sprayed into the nose raised follicle stimulating hormone more than saline.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMean FSH in women with hypothalamic amenorrhoea
Study
n = 4
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
12.8 nmol/kg · intranasalAs given in this study (human).
Source sentences
Summary
Intranasal kisspeptin increased mean FSH (p=0.01 vs saline).
1 context sentence(design, population, supporting numbers)
Summary · context
Subsequently, four women (mean age 29.8±3.7 yrs; BMI 21.2±1.1 kg/m2) with hypothalamic amenorrhoea (HA) attended for the same protocol comparing intranasal kisspeptin-54 (12.8 nmol/kg) and 0.9% saline.
Report a problemFND-9985600211
12HumanNon-randomized trialEfficacy outcome
In the acute four-hour study, intranasal kisspeptin‑54 caused no significant change in serum oestradiol.
In plain wordsIn the four-hour study, nasal kisspeptin caused no significant change in oestradiol.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeSerum oestradiol
Study
n: not reported in source
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
No significant changes in downstream serum oestradiol or progesterone were observed during the acute four-hour study.
Report a problemFND-9985600212
13HumanNon-randomized trialEfficacy outcome
In the acute four-hour study, intranasal kisspeptin‑54 caused no significant change in serum progesterone.
In plain wordsIn the four-hour study, nasal kisspeptin caused no significant change in progesterone.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeSerum progesterone
Study
n: not reported in source
Comparator
0.9% saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
No significant changes in downstream serum oestradiol or progesterone were observed during the acute four-hour study.
Report a problemFND-9985600213

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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Abstract

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