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Study · Not a test of the peptide alone · 2017

3 results

Functional studies of kisspeptin analogues and the human kisspeptin receptor

Zhang X

University of Liverpool1 Jan 2017

DOI10.17638/03011698 (opens in a new tab)PepBankPUB-99736707
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneOther designActivity measurement

    Among three synthetic phosphinic peptides based on KP-10, compound B had kisspeptin receptor-agonistic activity.

    In plain wordsIn lab tests, one of three new KP-10-based peptides, compound B, activated the kisspeptin receptor.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin receptor agonism by compound B
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    compound B possesses the kisspeptin receptor-agonistic activity
    1 context sentence
    Summary · context
    To improve the metabolic stability of kisspeptins, in the thesis, three novel phosphinic peptides were designed and synthesised based on the amino acid sequence of KP-10, which are the last ten amino acids shared by all native and functional kisspeptins.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneOther designActivity measurement

    Compound B, a synthetic phosphinic peptide based on KP-10, could function as a selective inhibitor of MMP-2.

    In plain wordsIn lab tests, compound B, a KP-10-based peptide, could selectively block the enzyme MMP-2.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableMMP-2 inhibition by compound B
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    could function as a selective inhibitor of MMP-2.
    1 context sentence
    Summary · context
    To improve the metabolic stability of kisspeptins, in the thesis, three novel phosphinic peptides were designed and synthesised based on the amino acid sequence of KP-10, which are the last ten amino acids shared by all native and functional kisspeptins.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03LabNot a test of Kisspeptin-10 aloneOther designActivity measurement

    Binding of the synthesized KP-10-based phosphinic peptides to the kisspeptin receptor was undetectable with the methods used.

    In plain wordsIn lab tests, binding of the new KP-10-based peptides to the kisspeptin receptor could not be detected.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeReceptor binding of synthesized phosphinic peptides
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    However, the binding of the synthesized peptides to the kisspeptin receptor was undetectable using the presented methods.
    1 context sentence
    Summary · context
    To improve the metabolic stability of kisspeptins, in the thesis, three novel phosphinic peptides were designed and synthesised based on the amino acid sequence of KP-10, which are the last ten amino acids shared by all native and functional kisspeptins.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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