LUM-201 Elicits Greater GH Response than Standard GH Secretagogues in Pediatric Growth Hormone Deficiency

Bright G, Smith R, Thorner M

Journal of the Endocrine Society3 May 2021

PMCIDPMC8265876PepBankPUB-99296059

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanNon-randomized trialEfficacy outcome
In prepubertal children with GHD, maximal GH response was greater after LUM-201 than standard stimuli.
In plain wordsIn children with growth hormone deficiency, LUM-201 produced a greater growth hormone response than standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseMaximal GH response
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
Median maximal GH
15 ng/mL
LUM-201
Median maximal GH
5.4 ng/mL
standard stimuli
Interquartile range of median maximal GH response
3.5 to 49 ng/mL
single-dose LUM-201
Interquartile range of median maximal GH response
1.8 to 7.6 ng/mL
pairs of standard stimuli
P value
< 0.00001
maximal GH response: single-dose LUM-201 versus standard stimuli
Source sentences
Summary
The median (interquartile range) of maximal GH response to single dose LUM-201 was 15.0 ng/mL (3.5, 49) and to various pairs of standard stimuli was 5.4 ng/mL (1.8-7.6) (p< 0.00001).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605901
02HumanNon-randomized trialEfficacy outcome
In prepubertal children with GHD, the median GH response difference between LUM-201 and standard stimuli was 9.6 ng/ml.
In plain wordsIn children with growth hormone deficiency, the median response advantage for LUM-201 over standard tests was 9.6 ng/ml.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseGH response difference
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
Median GH response difference
9.6 ng/ml
LUM-201 minus standard stimuli
Interquartile range of median GH response difference
1.9 to 42 ng/ml
LUM-201 minus standard stimuli
Source sentences
Summary
The median (IQR) for the difference between GH responses to LUM-201 and standard stimuli was 9.6 ng/ml (1.9, 42).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605902
03HumanNon-randomized trialOther
In children with GHD, higher baseline IGF-I was linked to a greater GH response advantage for LUM-201 over standard stimuli.
In plain wordsIn children, higher baseline IGF-I was linked to a greater LUM-201 growth hormone response advantage over standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseBaseline IGF-I association with differential GH
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
P value
< 0.00001
baseline IGF-I association with differential GH in the multivariate analysis
Source sentences
Summary
In a multivariate analysis (r2 =0.73) differential GH increased with higher values of baseline IGF-I (p < 0.00001) and standard GH stimulation test (p = 0.047)
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605903
04HumanNon-randomized trialOther
In children with GHD, higher standard stimulation responses were linked to a greater GH response advantage for LUM-201 over standard stimuli.
In plain wordsIn children, higher standard test responses were linked to a greater LUM-201 response advantage over standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseStandard stimulation response association
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
P value
0.047
standard GH stimulation test association with differential GH in the multivariate analysis
Source sentences
Summary
In a multivariate analysis (r2 =0.73) differential GH increased with higher values of baseline IGF-I (p < 0.00001) and standard GH stimulation test (p = 0.047)
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605904
05HumanNon-randomized trialOther
In children with GHD, age did not significantly influence the GH response difference between LUM-201 and standard stimuli.
In plain wordsIn children, age had no significant association with the growth hormone response difference between LUM-201 and standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeAge association with differential GH
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
P value
0.16
age association with differential GH in the multivariate analysis
Source sentences
Summary
but was not influenced by age (p = 0.16), sex (p = 0.28), baseline HV (p = 0.24), age-bone age differences (p = 0.33) or height-SDS (p = 0.75).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605905
06HumanNon-randomized trialOther
In children with GHD, sex did not significantly influence the GH response difference between LUM-201 and standard stimuli.
In plain wordsIn children, sex had no significant association with the growth hormone response difference between LUM-201 and standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeSex association with differential GH
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
P value
0.28
sex association with differential GH in the multivariate analysis
Source sentences
Summary
but was not influenced by age (p = 0.16), sex (p = 0.28), baseline HV (p = 0.24), age-bone age differences (p = 0.33) or height-SDS (p = 0.75).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605906
07HumanNon-randomized trialOther
In children with GHD, baseline height velocity did not significantly influence the GH response difference between LUM-201 and standard stimuli.
In plain wordsIn children, baseline growth velocity had no significant association with the response difference between LUM-201 and standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeBaseline height velocity association
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single dose · oral · single doseAs given in this study (human).
Measurements
P value
0.24
baseline HV association with differential GH in the multivariate analysis
Source sentences
Summary
but was not influenced by age (p = 0.16), sex (p = 0.28), baseline HV (p = 0.24), age-bone age differences (p = 0.33) or height-SDS (p = 0.75).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605907
08HumanNon-randomized trialOther
In children with GHD, age-bone age differences did not significantly influence the GH response difference between LUM-201 and standard stimuli.
In plain wordsIn children, age-bone age differences had no significant association with the response difference between LUM-201 and standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeAge-bone age difference association
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single doseAs given in this study (human).
Measurements
P value
0.33
age-bone age differences
Source sentences
Summary
but was not influenced by age (p = 0.16), sex (p = 0.28), baseline HV (p = 0.24), age-bone age differences (p = 0.33) or height-SDS (p = 0.75).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605908
09HumanNon-randomized trialOther
In children with GHD, height-SDS did not significantly influence the GH response difference between LUM-201 and standard stimuli.
In plain wordsIn children, height scores had no significant association with the growth hormone response difference between LUM-201 and standard tests.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeHeight SDS association
Study
n = 68
Comparator
standard GH stimulation tests
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.8 mg/kg single doseAs given in this study (human).
Measurements
P value
0.75
height-SDS
Source sentences
Summary
but was not influenced by age (p = 0.16), sex (p = 0.28), baseline HV (p = 0.24), age-bone age differences (p = 0.33) or height-SDS (p = 0.75).
1 context sentence(design, population, supporting numbers)
Summary · context
68 naïve-to-treatment, prepubertal children with GHD received two standard GH stimulation tests and a test with a single 0.8 mg/kg dose of LUM-201.
Report a problemFND-9929605909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Abstract

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