Skip to content

Study · Animal study (in vivo) · goat · 2012

4 results

Kisspeptin‐10 stimulates the release of luteinizing hormone and testosterone in pre‐ and post‐pubertal male goats

SAITO H, SAWADA T, YAEGASHI T, GOTO Y, Jin J, SAWAI K, Hashizume T

Animal science journal =1 Jun 2012

PepBankPUB-99209647
Ask about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pre-pubertal and post-pubertal male goats, a single intravenous Kp10 injection stimulated luteinizing hormone release.

    In plain wordsIn male goats, one injection of kisspeptin‑10 raised luteinizing hormone, both before and after puberty.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after Kp10
    Study

    goatn = 4

    male Shiba goats at 3 (pre-pubertal) and 6 (post-pubertal) months of age
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 µg/kg body weight · intravenous · single injectionAs given in this study (goat).

    Source sentences

    Summary
    A single i.v. injection of Kp10 significantly stimulated the release of LH and T in both groups.
    1 context sentence
    Summary · context
    Four male goats (Shiba goats) were given an intravenous (i.v.) injection of Kp10 (5 µg/kg body weight (b.w.)), gonadotoropin‐releasing hormone (GnRH, 1 µg/kg b.w.), or 2 mL of saline as a control at the ages of 3 (pre‐pubertal) and 6 (post‐pubertal) months.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pre-pubertal and post-pubertal male goats, a single intravenous Kp10 injection stimulated testosterone release.

    In plain wordsIn male goats, one injection of kisspeptin‑10 raised testosterone, both before and after puberty.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTestosterone release after Kp10
    Study

    goatn = 4

    male Shiba goats at 3 (pre-pubertal) and 6 (post-pubertal) months of age
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 µg/kg body weight · intravenous · single injectionAs given in this study (goat).

    Source sentences

    Summary
    A single i.v. injection of Kp10 significantly stimulated the release of LH and T in both groups.
    1 context sentence
    Summary · context
    Four male goats (Shiba goats) were given an intravenous (i.v.) injection of Kp10 (5 µg/kg body weight (b.w.)), gonadotoropin‐releasing hormone (GnRH, 1 µg/kg b.w.), or 2 mL of saline as a control at the ages of 3 (pre‐pubertal) and 6 (post‐pubertal) months.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    The LH area under the response curve over 60 minutes after Kp10 was greater in pre-pubertal than in post-pubertal goats.

    In plain wordsIn goats, the luteinizing hormone response to kisspeptin‑10 was larger before puberty than after puberty.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH AUC over 60 min, pre-pubertal versus post-pubertal
    Study

    goatn = 4

    male Shiba goats at 3 (pre-pubertal) and 6 (post-pubertal) months of age
    Comparator
    Post-pubertal goats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 µg/kg body weight · intravenous · single injectionAs given in this study (goat).

    Source sentences

    Summary
    The area under the response curve (AUC) of LH for a 60‐min period after the i.v. injection of Kp10 was significantly greater in the pre‐pubertal goats (P < 0.05).
    1 context sentence
    Summary · context
    Four male goats (Shiba goats) were given an intravenous (i.v.) injection of Kp10 (5 µg/kg body weight (b.w.)), gonadotoropin‐releasing hormone (GnRH, 1 µg/kg b.w.), or 2 mL of saline as a control at the ages of 3 (pre‐pubertal) and 6 (post‐pubertal) months.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    The testosterone area under the response curve over 120 minutes after Kp10 did not differ between pre-pubertal and post-pubertal goats.

    In plain wordsIn goats, the testosterone response to kisspeptin‑10 was similar before and after puberty.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTestosterone AUC over 120 min, pre-pubertal versus post-pubertal
    Study

    goatn = 4

    male Shiba goats at 3 (pre-pubertal) and 6 (post-pubertal) months of age
    Comparator
    Post-pubertal goats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 µg/kg body weight · intravenous · single injectionAs given in this study (goat).

    Source sentences

    Summary
    The AUC of T for a 120 min period post‐injection did not differ between the two age groups.
    1 context sentence
    Summary · context
    Four male goats (Shiba goats) were given an intravenous (i.v.) injection of Kp10 (5 µg/kg body weight (b.w.)), gonadotoropin‐releasing hormone (GnRH, 1 µg/kg b.w.), or 2 mL of saline as a control at the ages of 3 (pre‐pubertal) and 6 (post‐pubertal) months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.