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Study · Non-randomized trial · 1997

5 results

Growth hormone releasing peptides : physiological studies in man

Massoud AF

University College London (University of London)1 Jan 1997

PepBankPUB-98702990
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In healthy young adult males, hexarelin was a potent GH secretagogue that induced GH release after two successive administrations.

    In plain wordsIn healthy young men, hexarelin released growth hormone after each of two doses.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release after repeated hexarelin administration
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Studies which demonstrated that hexarelin is a potent growth hormone (GH) secretagogue, capable of inducing GH release after two successive administrations.
    1 context sentence
    Summary · context
    Four groups of studies were conducted on young, healthy, adult male volunteers
  2. 02HumanNon-randomized trialActivity measurement

    In healthy young adult males, hexarelin induced prolactin and cortisol release in a dose-related manner.

    In plain wordsIn healthy young men, hexarelin raised prolactin and cortisol, and higher doses raised them more.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin and cortisol release
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This group of studies also showed that hexarelin is non-specific for GH release, inducing prolactin (PRL) and cortisol release in a dose-related manner.
    1 context sentence
    Summary · context
    Four groups of studies were conducted on young, healthy, adult male volunteers

Studies that did not test the peptide alone3

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 03HumanNot a test of Hexarelin aloneNon-randomized trialActivity measurement

    In healthy young adult males, the synergy of a GHRP with GHRH, which gave massive GH release, was lost on repeated administration.

    In plain wordsIn healthy young men, the extra growth hormone release seen when a GHRP was given with GHRH did not occur on repeat dosing.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to GHRP plus GHRH, loss of synergy on repeat dosing
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    GHRP acts synergistically with growth hormone releasing hormone (GHRH) to induce massive GH release. However, this synergistic action is lost on repeated administration.
    2 context sentences
    Summary · context
    This work describes physiological studies of the growth hormone releasing peptide (GHRP) hexarelin.
    Summary · context
    Four groups of studies were conducted on young, healthy, adult male volunteers

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 04HumanNot a test of Hexarelin aloneNon-randomized trialActivity measurement

    In healthy young adult males, GH itself attenuated the GH response to a GHRP.

    In plain wordsIn healthy young men, growth hormone itself reduced the growth hormone response to a GHRP.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH attenuates the GH response to GHRP
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Studies which showed that GH itself attenuates the GH response to GHRP.
    2 context sentences
    Summary · context
    This work describes physiological studies of the growth hormone releasing peptide (GHRP) hexarelin.
    Summary · context
    Four groups of studies were conducted on young, healthy, adult male volunteers

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 05HumanNot a test of Hexarelin aloneNon-randomized trialActivity measurement

    In healthy young adult males, the GH-releasing activity of a GHRP, alone or with GHRH, was attenuated but not abolished by increasing somatostatin tone.

    In plain wordsIn healthy young men, raising somatostatin reduced but did not stop growth hormone release from a GHRP, alone or with GHRH.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH release under increased somatostatin tone
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Studies which showed that the GH-releasing activity of GHRP, alone or in combination with GHRH, is attenuated but not abolished by increasing somatostatin (SS) tone.
    2 context sentences
    Summary · context
    This work describes physiological studies of the growth hormone releasing peptide (GHRP) hexarelin.
    Summary · context
    Four groups of studies were conducted on young, healthy, adult male volunteers

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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