Immunohistochemical localization of kisspeptin and kisspeptin receptor in the equine ovary: Effect of follicle size and reproductive state

Gilbert BM, Bailey VN, Gomes VC, Sones JL, Oberhaus EL

Journal of equine veterinary science1 Jun 2024

PepBankPUB-97748938

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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelOther designOther
In mare ovaries, Kp10 and Kiss1r staining was detected in all follicle sizes in all reproductive states, and in oocytes and corpora lutea.
In plain wordsIn mares, the body's own kisspeptin‑10 and its receptor were found in follicles, eggs and corpora lutea.
Peptide
Kisspeptin-10
Outcome
Not applicableLocalization of Kp10 and Kiss1r staining
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Staining for Kp10 and Kiss1r was detected in all follicle sizes throughout all reproductive states, as well as in oocytes and corpora lutea.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893801
02AnimalEndogenous levelOther designOther
In mare ovaries, Kp10 and Kiss1r staining intensity differed between all follicle sizes and was greatest in antral follicles.
In plain wordsIn mares, the body's own kisspeptin‑10 and its receptor were strongest in the largest follicles.
Peptide
Kisspeptin-10
Outcome
IncreaseStaining intensity by follicle size
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Staining intensity for both differed between all follicle sizes and was greatest (P < 0.01)in antral follicles.
2 context sentences(design, population, supporting numbers)
Summary · context
Staining intensity for both increased as follicle size increased.
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893802
03AnimalEndogenous levelOther designOther
In mare ovaries, Kp10 and Kiss1r staining was similar in preantral follicles across states and greater than in primordial follicles.
In plain wordsIn mares, the body's own kisspeptin‑10 and its receptor were stronger in mid-stage follicles than in the smallest follicles.
Peptide
Kisspeptin-10
Outcome
IncreaseStaining in preantral versus primordial follicles
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Staining for Kp10 and Kiss1r was similar in preantral follicles of all reproductive states but was greater (P < 0.01) than primordial follicles.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893803
04AnimalEndogenous levelOther designOther
In mare primordial follicles, Kp10 and Kiss1r staining was greatest in ECP-sulpiride stimulated ovaries and similar across all other states.
In plain wordsIn mares, the body's own kisspeptin‑10 and its receptor were strongest in the smallest follicles of treated ovaries.
Peptide
Kisspeptin-10
Outcome
IncreaseStaining in primordial follicles by reproductive state
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In primordial follicles, staining for Kp10 and Kiss1r was greatest (P < 0.01) in ECP-sulpiride stimulated ovaries, but similar between all other states.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893804
05AnimalEndogenous levelOther designOther
In mare antral follicles, Kp10 and Kiss1r staining was greatest in follicular-phase and ECP-sulpiride stimulated ovaries.
In plain wordsIn mares, the body's own kisspeptin‑10 and its receptor were strongest in large follicles of ovaries in the follicular phase or after treatment.
Peptide
Kisspeptin-10
Outcome
IncreaseStaining in antral follicles by reproductive state
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Kisspeptin-10 and Kiss1r staining was greatest (P < 0.01) in antral follicles of FP and ECP-sulpiride stimulated ovaries.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893805
06AnimalEndogenous levelOther designOther
In granulosa cells of mare antral follicles, Kp10 and Kiss1r staining was most intense in follicular-phase and ECP-sulpiride stimulated ovaries, more than in luteal-phase and anovulatory ovaries.
In plain wordsIn mares, the body's own kisspeptin‑10 and its receptor were strongest in follicle cells of active or treated ovaries compared with luteal-phase and anovulatory ovaries.
Peptide
Kisspeptin-10
Outcome
IncreaseGranulosa cell staining by reproductive state
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Staining for both Kp10 and Kiss1r was most intense in GC of FP and ECP-sulpiride-stimulated ovaries and was greater (P < 0.0001) than LP and SA ovaries.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893806
07AnimalEndogenous levelOther designOther
In mare granulosa cells, Kp10 and Kiss1r staining did not differ between luteal-phase and seasonally anovulatory ovaries.
In plain wordsIn mares, natural kisspeptin‑10 and receptor levels in follicle cells were similar in luteal-phase and anovulatory ovaries.
Peptide
Kisspeptin-10
Outcome
No significant changeGranulosa cell staining, luteal-phase versus seasonally anovulatory ovaries
Study
horsen: not reported in source
Mare ovaries, immunohistochemistry
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
No differences were detected between LP and SA.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight ovaries were collected from light-horse mares during the breeding and non-breeding seasons and characterized as FP (n = 3), LP (n = 2), or SA (n = 3).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9774893807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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