INHIBITING INVASION AND STEMNESS IN GLIOBLASTOMA BY THYMOSIN BETA 4 GENE SILENCING: A POTENTIAL THERAPEUTIC TARGET?

Tabatabai G, Wirsching H, Krishnan S, Florea A, Frei K, Krayenbühl N, Hasenbach K, Reifenberger G, Weller M

Neuro-oncology1 Jul 2014

PMCIDPMC4144549PepBankPUB-95921470

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In human gliomas, TB4 expression increased with the grade of malignancy.
In plain wordsIn people with brain tumors, the body's own thymosin beta‑4 was higher in more malignant tumors.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTB4 expression by glioma grade
Study
n: not reported in source
glioma tissue
Outcome group
Tumor growth · Cancer
Source sentences
Summary
TB4 expression increased with the grade of malignancy in gliomas
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed TB4 expression on tissue microarrays and performed REMBRANDT and TCGA database interrogations.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9592147001
02HumanEndogenous levelObservational studyOther
In patients with glioblastoma, TB4 expression correlated with patient survival.
In plain wordsIn people with glioblastoma, natural thymosin beta‑4 levels were linked to survival.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableTB4 expression and survival in glioblastoma
Study
n: not reported in source
glioma tissue
Outcome group
Tumor growth · Cancer
Source sentences
Summary
correlated with patient survival in glioblastoma.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed TB4 expression on tissue microarrays and performed REMBRANDT and TCGA database interrogations.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-9592147002

Studies that did not test the peptide alone9

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In nude mice bearing tumors from TB4-depleted glioma cells, survival was improved.
In plain wordsIn mice, tumors made from cells with silenced thymosin beta‑4 led to longer survival.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSurvival of nude mice with TB4-depleted glioma cells
Study
mousen: not reported in source
nude mice with orthotopic tumors from glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vivo, survival of nude mice bearing tumors derived from TB4-depleted glioma cells was improved and the tumorigenicity of the GS-2 glioma stem-cell line was decreased.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied clonogenic survival, migration, invasion, sphere formation anddifferentiation capacity of TB4-depleted or TB4-overexpressing glioma cells in vitro, and tumorigenicity upon orthotopic implantation in vivo.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147009
04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In nude mice, tumorigenicity of the GS-2 glioma stem-cell line was decreased after TB4 depletion.
In plain wordsIn mice, brain tumor stem cells with silenced thymosin beta‑4 formed tumors less well.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTumorigenicity of GS-2 glioma stem-cell line after TB4 depletion
Study
mousen: not reported in source
nude mice with orthotopic tumors from glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vivo, survival of nude mice bearing tumors derived from TB4-depleted glioma cells was improved and the tumorigenicity of the GS-2 glioma stem-cell line was decreased.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied clonogenic survival, migration, invasion, sphere formation anddifferentiation capacity of TB4-depleted or TB4-overexpressing glioma cells in vitro, and tumorigenicity upon orthotopic implantation in vivo.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147010
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In glioma cells, TB4 gene silencing decreased migration.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene reduced cell migration.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMigration after TB4 silencing
Study
humann: not reported in source
LNT-229, U87MG and GS-2 glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vitro, TB4 gene silencing by lentiviral transduction decreased migration, invasion, growth and self-renewal, and promoted differentiation and the susceptibility to undergo apoptotic cell death upon nutrient depletion in LNT-229, U87MG and the glioma stem-cell line GS-2, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Using lentiviral transduction, we modulated TB4 expression in the long-term glioma cell lines LNT-229 and U87MG, and in the glioma-initiating cell line GS-2.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147003
06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In glioma cells, TB4 gene silencing decreased invasion.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene reduced cell invasion.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseInvasion after TB4 silencing
Study
humann: not reported in source
LNT-229, U87MG and GS-2 glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vitro, TB4 gene silencing by lentiviral transduction decreased migration, invasion, growth and self-renewal, and promoted differentiation and the susceptibility to undergo apoptotic cell death upon nutrient depletion in LNT-229, U87MG and the glioma stem-cell line GS-2, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Using lentiviral transduction, we modulated TB4 expression in the long-term glioma cell lines LNT-229 and U87MG, and in the glioma-initiating cell line GS-2.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147004
07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In glioma cells, TB4 gene silencing decreased growth.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene reduced cell growth.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseGrowth after TB4 silencing
Study
humann: not reported in source
LNT-229, U87MG and GS-2 glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vitro, TB4 gene silencing by lentiviral transduction decreased migration, invasion, growth and self-renewal, and promoted differentiation and the susceptibility to undergo apoptotic cell death upon nutrient depletion in LNT-229, U87MG and the glioma stem-cell line GS-2, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Using lentiviral transduction, we modulated TB4 expression in the long-term glioma cell lines LNT-229 and U87MG, and in the glioma-initiating cell line GS-2.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147005
08LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In glioma cells, TB4 gene silencing decreased self-renewal.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene reduced self-renewal.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSelf-renewal after TB4 silencing
Study
humann: not reported in source
LNT-229, U87MG and GS-2 glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vitro, TB4 gene silencing by lentiviral transduction decreased migration, invasion, growth and self-renewal, and promoted differentiation and the susceptibility to undergo apoptotic cell death upon nutrient depletion in LNT-229, U87MG and the glioma stem-cell line GS-2, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Using lentiviral transduction, we modulated TB4 expression in the long-term glioma cell lines LNT-229 and U87MG, and in the glioma-initiating cell line GS-2.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147006
09LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In glioma cells, TB4 gene silencing promoted differentiation.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene promoted cell differentiation.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseDifferentiation after TB4 silencing
Study
humann: not reported in source
LNT-229, U87MG and GS-2 glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vitro, TB4 gene silencing by lentiviral transduction decreased migration, invasion, growth and self-renewal, and promoted differentiation and the susceptibility to undergo apoptotic cell death upon nutrient depletion in LNT-229, U87MG and the glioma stem-cell line GS-2, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Using lentiviral transduction, we modulated TB4 expression in the long-term glioma cell lines LNT-229 and U87MG, and in the glioma-initiating cell line GS-2.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147007
10LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In glioma cells, TB4 gene silencing promoted susceptibility to apoptotic cell death upon nutrient depletion.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene made cells more prone to die when starved of nutrients.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSusceptibility to apoptotic cell death upon nutrient depletion after TB4 silencing
Study
humann: not reported in source
LNT-229, U87MG and GS-2 glioma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In vitro, TB4 gene silencing by lentiviral transduction decreased migration, invasion, growth and self-renewal, and promoted differentiation and the susceptibility to undergo apoptotic cell death upon nutrient depletion in LNT-229, U87MG and the glioma stem-cell line GS-2, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Using lentiviral transduction, we modulated TB4 expression in the long-term glioma cell lines LNT-229 and U87MG, and in the glioma-initiating cell line GS-2.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147008
11LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In glioma cells, TB4 gene silencing shifted the gene expression pattern from a mesenchymal toward a pro-neural signature and modulated TGF-beta and p53 signaling networks.
In plain wordsIn lab tests on brain tumor cells, silencing the thymosin beta‑4 gene shifted gene activity toward a less aggressive pattern.
Peptide
Thymosin beta-4 (human)
Outcome
MixedGene expression pattern after TB4 silencing
Study
humann: not reported in source
glioma cells
Outcome group
Receptor activity and mechanism · Cancer
Source sentences
Summary
The gene expression pattern was shifted from the mesenchymal towards the pro-neural gene signature upon TB4 gene silencing, thereby modulating TGF-beta and p53 signaling networks.
1 context sentence(design, population, supporting numbers)
Summary · context
Finally, we performed a genome wide mRNA expression analysis to unravel the molecular network of TB4 signaling effects.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-9592147011

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Abstract

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