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Study · Animal study (in vivo) · guinea-pig · 1957

2 results

The effect of adrenocorticotropin on the nucleic acids and histochemistry of the guinea-pig adrenal cortex

Burns JK

University of Glasgow1 Jan 1957

PepBankPUB-95836777
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mature guinea-pigs, mean adrenal nuclear DM content was similar to same-slide controls except after 5 and 7 treatment days.

    In plain wordsIn guinea-pigs, adrenal nuclear DM content was similar to same-slide controls except after 5 and 7 days of ACTHar gel.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changeMean adrenal nuclear DM content outside 5 and 7 days
    Study

    guinea-pign: not reported in source

    Mature guinea-pig adrenal cortex
    Comparator
    Control specimen on the same slide
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean adrenal nuclear DM content was similar to that in a control specimen mounted on the same slide in each instance, except after administration of adrenocorticotropin for 5 and 7 days.
    1 context sentence
    Summary · context
    The effect of adrenocorticotropin (Armour ACTHar gel) on the mean amount of deoxyribonucleic acid (DNA) per nucleus, and the scatter about this mean, in adrenal nuclei from mature guinea-pigs was studied, using cytophotometry of Feulgen stained nuclear smears.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In mature guinea-pigs, ACTHar gel significantly increased mean adrenal nuclear DNA content after 5 and 7 days (P < 0.01).

    In plain wordsIn guinea-pigs, ACTHar gel increased adrenal nuclear DNA content versus same-slide controls after 5 and 7 days.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseMean adrenal nuclear DNA content
    Study

    guinea-pign: not reported in source

    Mature guinea-pig adrenal cortex
    Comparator
    Control specimen on the same slide
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · 5 and 7 daysAs given in this study (guinea-pig).

    Measurements

    P value
    < 0.01
    mean adrenal nuclear DNA

    Source sentences

    Summary
    Cytophotometric analyses showed a highly statistically significant increase (P < 0.01) in mean adrenal nuclear DNA content after treatment of the animals with ACTH for 5 and 7 days
    1 context sentence
    Summary · context
    The effect of adrenocorticotropin (Armour ACTHar gel) on the mean amount of deoxyribonucleic acid (DNA) per nucleus, and the scatter about this mean, in adrenal nuclei from mature guinea-pigs was studied, using cytophotometry of Feulgen stained nuclear smears.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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