Skip to content

Study · Measured the body's own peptide · 2005

1 result

IN VITRO GENE EXPRESSION ASSAY FOR DETERMINING FLUOROPYRIMIDINE SENSITIVITY IN CHEMOTHERAPY

JOHNSTON Patrick Gerard, LONGLEY David Broderick, MAXWELL Pamela Joan

Journal not recorded30 Jul 2004

PepBankPUB-95831271
Source linkAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In the MCF-7 breast cancer cell line, treatment with fluoropyrimidines upregulated the gene encoding thymosin beta‑4.

    In plain wordsIn breast cancer cells, treatment with fluoropyrimidine drugs raised the activity of the body's own thymosin beta‑4 gene.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 gene upregulation after fluoropyrimidine treatment
    Study

    n: not reported in source

    MCF-7 breast cancer cell line
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Upregulated genes included the genes encoding Raf, K-ras, SLAP, phosphoinositide 3-kinase, COP9 homolog (HCOP9), apoptosis specific protein, APO-1 cell surface antigen, FLIP protein, cyclin G, CDC2 , cyclin --dependent protein kinase -2, thymosin beta-10, myosin light chain (MLC-2), gelsolin, thymosin beta-4
    1 context sentence
    Summary · context
    DNA microarray technology was used to investigate changes in the transcriptional profile of the MCF-7 breast cancer cell line following treatment with fluoropyrimidines.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.