Skip to content

Study · Animal study (in vivo) · horse · 2022

5 results

19 Interaction of kisspeptin and the somatotropic and lactotropic axes in mares and geldings

Bailey VN, Camp CM, Oberhaus EL

Journal of equine veterinary science1 May 2022

PepBankPUB-93213119
Ask about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mares and geldings, kisspeptin‑10 did not stimulate growth hormone after pre-treatment with estradiol, progesterone or oil.

    In plain wordsIn horses, kisspeptin‑10 did not raise growth hormone, with or without estradiol or progesterone beforehand.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGH response to Kp10 after estradiol or progesterone pre-treatment (experiment 2)
    Study

    horsen = 30

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (horse).

    Source sentences

    Summary
    No stimulation of GH or PRL was observed.
    1 context sentence
    Summary · context
    In a second experiment, 30 mares and geldings were used to determine if pre-treatment with estradiol or progesterone would elicit a GH or PRL response to Kp10
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mares and geldings, kisspeptin‑10 did not stimulate prolactin after pre-treatment with estradiol, progesterone or oil.

    In plain wordsIn horses, kisspeptin‑10 did not raise prolactin, with or without estradiol or progesterone beforehand.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePRL response to Kp10 after estradiol or progesterone pre-treatment (experiment 2)
    Study

    horsen = 30

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (horse).

    Source sentences

    Summary
    No stimulation of GH or PRL was observed.
    1 context sentence
    Summary · context
    In a second experiment, 30 mares and geldings were used to determine if pre-treatment with estradiol or progesterone would elicit a GH or PRL response to Kp10
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mares and geldings, a 1 mg intravenous dose of kisspeptin‑10 did not stimulate growth hormone compared with saline.

    In plain wordsIn horses, kisspeptin‑10 did not raise growth hormone compared with saline.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGH response to Kp10 (experiment 1)
    Study

    horsen = 19

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (horse).

    Source sentences

    Summary
    Neither GH nor PRL were stimulated by Kp10.
    1 context sentence
    Summary · context
    Light horse, diestrous mares and geldings, weighing approximately 500 kg and aged 6 to 24 years, were randomly assigned to treatment with 1 mg equine kisspeptin-10 (Kp10; n = 10) or 1 mL saline (n = 9), i.v. Blood samples were collected via jugular venipuncture −10, 0, 5, 10, 15, 20 and 30 min relative to treatment.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mares and geldings, a 1 mg intravenous dose of kisspeptin‑10 did not stimulate prolactin compared with saline.

    In plain wordsIn horses, kisspeptin‑10 did not raise prolactin compared with saline.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePRL response to Kp10 (experiment 1)
    Study

    horsen = 19

    Comparator
    Saline
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (horse).

    Source sentences

    Summary
    Neither GH nor PRL were stimulated by Kp10.
    1 context sentence
    Summary · context
    Light horse, diestrous mares and geldings, weighing approximately 500 kg and aged 6 to 24 years, were randomly assigned to treatment with 1 mg equine kisspeptin-10 (Kp10; n = 10) or 1 mL saline (n = 9), i.v. Blood samples were collected via jugular venipuncture −10, 0, 5, 10, 15, 20 and 30 min relative to treatment.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diestrous mares, prolactin concentrations after sulpiride were lower in kisspeptin‑10-treated mares than in saline-treated mares.

    In plain wordsIn mares, the prolactin rise after sulpiride was smaller with kisspeptin‑10 than with saline.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePRL response to sulpiride in Kp10-treated mares (experiment 3)
    Study

    horsen = 12

    Comparator
    Saline then sulpiride
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (horse).

    Source sentences

    Summary
    however, PRL concentrations were lower (P ≤ 0.01) in Kp10-treated mares compared with saline-treated mares.
    1 context sentence
    Summary · context
    In a third experiment, 12 diestrous mares, confirmed by plasma progesterone and ultrasound findings, were randomly assigned to treatment with 1 mg Kp10 (n = 6) or 1 mL saline (n = 6) followed by the dopamine antagonist, sulpiride (0.01 mg/kg body weight), 5 min later.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.