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Study · Animal study (in vivo) · cattle · 2019

6 results

PSVI-22 Immunity indicators of calves obtained from cows with ketosis during the treatment process

Kovalev S, Nikitina A, Anipchenko P, Stekolnikov A, Kiselenko P, Alekhin Y

Journal of animal science1 Dec 2019

PMCIDPMC6897805 (opens in a new tab)PepBankPUB-92844126
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In calves born to cows with ketosis, maternal Timolin treatment increased T-cell levels to 32.9% compared with calves from untreated cows.

    In plain wordsIn calves, maternal Timolin treatment increased T-cell levels compared with calves born to untreated cows.

    Peptide
    Thymalin
    Outcome
    IncreaseT-cell percentage
    Study

    cattlen: not reported in source

    Calves born to cows with ketosis
    Comparator
    Calves born to untreated cows
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    T-cell level
    32.9%
    Calves born to Timolin-treated cows

    Source sentences

    Summary
    Compared to calves obtained from untreated cows, the number of T-lymphocytes in young calves born from cows treated with Timolin increased the level of T-cells to 32.9%, while using Timosplenin 45%.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In calves born to cows with ketosis, maternal Timalin treatment increased relative blood T-lymphocyte content by 2.2 times.

    In plain wordsIn calves, maternal Timalin treatment increased relative T-cell levels compared with calves born to untreated cows.

    Peptide
    Thymalin
    Outcome
    IncreaseRelative T-lymphocyte content
    Study

    cattlen: not reported in source

    Calves born to cows with ketosis
    Comparator
    Calves born to untreated cows
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    Relative T-lymphocyte increase
    2.2 fold
    Calves born to Timalin-treated cows

    Source sentences

    Summary
    As a result of the use of immunomodulators in treating cows with ketosis in mothers, the relative content of T-lymphocytes in the blood of calves born from them increased when using the drug Leucogen by 1.7 times, Timosplenin by 2.3 times, Timalin in 2.2 times.
    1 context sentence
    Summary · context
    Compared to calves obtained from untreated cows, the number of T-lymphocytes in young calves born from cows treated with Timolin increased the level of T-cells to 32.9%, while using Timosplenin 45%.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In calves born to cows with ketosis, maternal Timalin treatment increased blood B-cell percentage by 42%.

    In plain wordsIn calves born to cows with ketosis, maternal Timalin treatment increased the percentage of B cells.

    Peptide
    Thymalin
    Outcome
    IncreaseB-cell percentage
    Study

    cattlen: not reported in source

    Calves born to cows with ketosis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    B-cell percentage increase
    42%
    Calves born to Timalin-treated cows

    Source sentences

    Summary
    The use of Leucogen for cows with ketosis contributed to an increase in the percentage of B cells in the blood of calves born by 23%, Timosplenin 83%, and Timalin 42%.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In calves born to cows with ketosis, maternal Timalin treatment increased absolute B-lymphocyte numbers by 2.3 times.

    In plain wordsIn calves born to cows with ketosis, maternal Timalin treatment increased absolute B-cell numbers.

    Peptide
    Thymalin
    Outcome
    IncreaseAbsolute B-lymphocyte number
    Study

    cattlen: not reported in source

    Calves born to cows with ketosis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    Absolute B-lymphocyte increase
    2.3 fold
    Timalin

    Source sentences

    Summary
    in the treatment with the preparations “Timosplenin” and “Timalin” - the increase was, respectively, 3.0 and 2.3 times and was higher this indicator in young animals born from healthy calves.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In calves from Timalin-treated cows, absolute B-lymphocyte numbers exceeded the healthy comparison described in the abstract.

    In plain wordsIn calves, maternal Timalin treatment increased absolute B-cell numbers above the reported healthy comparison.

    Peptide
    Thymalin
    Outcome
    IncreaseAbsolute B-lymphocyte number versus healthy comparison
    Study

    cattlen: not reported in source

    Calves born to cows with ketosis
    Comparator
    Young animals described as born from healthy calves
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in the treatment with the preparations “Timosplenin” and “Timalin” - the increase was, respectively, 3.0 and 2.3 times and was higher this indicator in young animals born from healthy calves.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In newborn calves, maternal Timalin treatment produced lymphocyte content above that in healthy young calves.

    In plain wordsIn newborn calves, maternal Timalin treatment increased lymphocyte content above levels in healthy young calves.

    Peptide
    Thymalin
    Outcome
    IncreaseLymphocyte content versus healthy young
    Study

    cattlen: not reported in source

    Calves born to cows with ketosis
    Comparator
    Healthy young calves
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under the influence of “Leucogen,” the percentage of lymphocytes was normalized, whereas with the introduction of “Timalin” and “Timosplenin,” the content of this type of cells in newborn calves even exceeded those in healthy young.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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