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Study · Measured the body's own peptide · 2011

3 results

The role of thymosin β4 in vascular development

Rossdeutsch A

University College London (University of London)1 Jan 2011

PepBankPUB-92538091
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mouse embryos, Tβ4 was expressed specifically in the endothelial cells of the developing vasculature.

    In plain wordsIn mouse embryos, the body's own Tβ4 was found in the cells that line the developing blood vessels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4 localisation in embryonic vasculature
    Study

    mousen: not reported in source

    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    Expression analyses demonstrated specific localisation of Tβ4/Tβ4 in the endothelial cells of the embryonic vasculature.
    1 context sentence
    Summary · context
    This PhD project seeks to build on these studies and characterises the function of Tβ4 in the developing systemic vasculature, using the mouse as a model system.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In mouse embryos, loss of Tβ4 (global or endothelial-specific) reduced the recruitment of mural cells to developing blood vessels.

    In plain wordsIn mouse embryos, removing the Tβ4 gene reduced the number of support cells that join developing blood vessels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseVascular mural cell recruitment in Tβ4 loss-of-function embryos
    Study

    mousen: not reported in source

    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    Both global and endothelial-specific Tβ4 mutant embryos displayed a reduced recruitment of vascular mural cells to developing blood vessels.
    1 context sentence
    Summary · context
    This PhD project seeks to build on these studies and characterises the function of Tβ4 in the developing systemic vasculature, using the mouse as a model system.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In Tβ4 mutant mouse embryos, the mural cell deficit was attributed to impaired differentiation of mature mural cells from undifferentiated mesoderm.

    In plain wordsIn mouse embryos lacking Tβ4, support cells for blood vessels formed less well from early tissue.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMural cell differentiation from mesoderm in Tβ4 mutants
    Study

    mousen: not reported in source

    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    Detailed phenotypic examination revealed that the mural cell deficit could be attributed to impaired differentiation of mature mural cells from undifferentiated mesoderm.
    1 context sentence
    Summary · context
    This PhD project seeks to build on these studies and characterises the function of Tβ4 in the developing systemic vasculature, using the mouse as a model system.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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