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Study · Case report or series · n = 1 · 2021

3 results

Early Treatment of Hypothalamic Hypogonadism With LH-RH Analog Improved the Long-Term Prognosis of Hypogonadism of Adult-Onset Craniopharyngioma

Iwabuchi M

Journal of the Endocrine Society3 May 2021

PMCIDPMC8090198 (opens in a new tab)PepBankPUB-92150498
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a man with hypothalamic hypogonadism after craniopharyngioma surgery, serum testosterone became normal after six months of pulsatile subcutaneous LH-RH treatment.

    In plain wordsIn one man with low testosterone after brain tumor surgery, testosterone became normal after six months of pulsed LH-RH treatment.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseSerum testosterone after pulsatile LH-RH treatment
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    16 micrograms every 120 min · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    After the six months of pulsatile LH-RH treatment, serum level of testosterone turned normal.
    3 context sentences
    Summary · context
    After a diagnosis of hypothalamic hypogonadism, low dose LH-RH treatment was given to a 29-year-old male with small portable automatically-timed infusion pump, connected to a subcutaneous (s.c.) catheter.
    Summary · context
    Gonadorelin acetate was prepared to the concentration of 0.8mg/ml.
    Summary · context
    Sixteen micrograms of LH-RH s.c. was given every 120 min.
  2. 02HumanCase report or seriesEfficacy outcome

    In a man with hypothalamic hypogonadism after craniopharyngioma surgery, his wife became pregnant, first with IVF and later naturally, after the LH-RH treatment was paused, suggesting recovery from oligospermia and asthenospermia.

    In plain wordsIn one man treated with pulsed LH-RH, his wife later became pregnant twice, once naturally, which suggests his sperm count and motility recovered.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseFertility recovery (pregnancies of partner)
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    16 micrograms every 120 min · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Then the treatment was paused in 2003. His wife became pregnant with in-vitro fertilization (IVF) in 2007 and gave birth in 2008. Moreover, his wife became pregnant naturally without IVF in 2009 and gave birth in 2010, suggesting the recovery from oligospermia and asthenospermia of her husband.
    3 context sentences
    Summary · context
    After a diagnosis of hypothalamic hypogonadism, low dose LH-RH treatment was given to a 29-year-old male with small portable automatically-timed infusion pump, connected to a subcutaneous (s.c.) catheter.
    Summary · context
    Gonadorelin acetate was prepared to the concentration of 0.8mg/ml.
    Summary · context
    Sixteen micrograms of LH-RH s.c. was given every 120 min.
  3. 03HumanCase report or seriesEfficacy outcome

    In a man with hypothalamic hypogonadism after craniopharyngioma surgery, normal gonadal function was maintained in 2020 after early recovery.

    In plain wordsIn one man treated with pulsed LH-RH, normal gonadal function was still present in 2020.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableMaintenance of gonadal function at long-term follow-up
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    16 micrograms every 120 min · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Early recovery from hypothalamic hypogonadism maintained normal gonadal function in 2020.
    3 context sentences
    Summary · context
    After a diagnosis of hypothalamic hypogonadism, low dose LH-RH treatment was given to a 29-year-old male with small portable automatically-timed infusion pump, connected to a subcutaneous (s.c.) catheter.
    Summary · context
    Gonadorelin acetate was prepared to the concentration of 0.8mg/ml.
    Summary · context
    Sixteen micrograms of LH-RH s.c. was given every 120 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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