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Study · Animal study (in vivo) · mouse and rat · 2001

8 results

Anxiolytic effect of BPC-157, a gastric pentadecapeptide: shock probe/burying test and light/dark test

Sikiric P, Jelovac N, Jelovac-Gjeldum A, Dodig G, Staresinic M, Anic T, Zoricic I, Perovic D, Aralica G, Buljat G, Prkacin I, Lovric-Bencic M and 6 more

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Separvoic J, Seiwerth S, Rucman R, Petek M, Turkovic B, Ziger T

Zhongguo yao li xue bao = Acta pharmacologica Sinica1 Jan 2001

PepBankPUB-91841236
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the shock probe/burying test, BPC‑157 reduced the total time spent burying compared with controls.

    In plain wordsIn rats, BPC‑157 reduced burying time after a shock compared with controls, a sign of less fear.

    Peptide
    BPC-157
    Outcome
    DecreaseBurying time in shock probe test
    Study

    ratn: not reported in source

    Shock probe/burying test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Shock probe/burying test: rats treated with either diazepam or pentadecapeptide BPC-157 were much less afraid after the shock; almost not burying and the total time spent in burying was clearly less than in controls.
    1 context sentence
    Summary · context
    In shock probe/burying test, pentadecapeptide BPC-157 (10#mu#g/kg, 10ng/kg, ip), diazepam (0.075, 0.0375mg/kg, ip) and an equivolume of saline (5mL/kg, ip) were given at 30 min prior test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the shock probe/burying test, the number of shocks received with BPC‑157 did not change compared with control values.

    In plain wordsIn rats, BPC‑157 did not change the number of shocks received compared with controls.

    Peptide
    BPC-157
    Outcome
    No significant changeNumber of shocks received
    Study

    ratn: not reported in source

    Shock probe/burying test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    in pentadecapeptide BPC-157 treated groups the number of shocks remained not modified compared with the control values.
    1 context sentence
    Summary · context
    In shock probe/burying test, pentadecapeptide BPC-157 (10#mu#g/kg, 10ng/kg, ip), diazepam (0.075, 0.0375mg/kg, ip) and an equivolume of saline (5mL/kg, ip) were given at 30 min prior test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 mice behaved like control mice, with no clear change in latency of crossing to the dark compartment.

    In plain wordsIn mice, BPC‑157 did not clearly change the time to cross into the dark compartment compared with controls.

    Peptide
    BPC-157
    Outcome
    No significant changeLatency of crossing to the dark compartment
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whole BPC-157 mice had a similar behavior to that of the control mice.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 mice behaved like control mice, with no clear change in the number of crossings.

    In plain wordsIn mice, BPC‑157 did not clearly change the number of crossings after bright light compared with controls.

    Peptide
    BPC-157
    Outcome
    No significant changeNumber of crossings in the light area
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whole BPC-157 mice had a similar behavior to that of the control mice.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 mice behaved like control mice, with no clear change in exploratory rearing.

    In plain wordsIn mice, BPC‑157 did not clearly change exploratory rearing after bright light compared with controls.

    Peptide
    BPC-157
    Outcome
    No significant changeExploratory rearing in the light area
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whole BPC-157 mice had a similar behavior to that of the control mice.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 mice behaved like control mice, with no clear change in time spent in the light compartment.

    In plain wordsIn mice, BPC‑157 did not clearly change the time spent in the light compartment compared with controls.

    Peptide
    BPC-157
    Outcome
    No significant changeTime in the light compartment
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whole BPC-157 mice had a similar behavior to that of the control mice.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 at 10 µg/kg increased the number of crossings in the dark zone compared with controls.

    In plain wordsIn mice, BPC‑157 increased the number of crossings in the dark zone compared with controls.

    Peptide
    BPC-157
    Outcome
    IncreaseNumber of crossings in the dark zone
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC-157 (10#mu#g/kg) mice had a greater number of crossing and a greater number of exploratory rearing.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 at 10 µg/kg increased exploratory rearing in the dark zone compared with controls.

    In plain wordsIn mice, BPC‑157 increased exploratory rearing in the dark zone compared with controls.

    Peptide
    BPC-157
    Outcome
    IncreaseExploratory rearing in the dark zone
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 µg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC-157 (10#mu#g/kg) mice had a greater number of crossing and a greater number of exploratory rearing.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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