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Study · Animal study (in vivo) · sheep · 2019

6 results

295 Awardee Talk: Novel regulation of growth hormone by kisspeptin

Sartin J, Daniel J, Foradori C, Whitlock B

Journal of animal science1 Dec 2019

PMCIDPMC6898158 (opens in a new tab)PepBankPUB-90753360
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 24 h fasted sheep, intracerebroventricular Kp-10 increased plasma growth hormone concentrations.

    In plain wordsIn fasted sheep, kisspeptin‑10 given into the brain raised growth hormone in the blood.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma GH in fasted sheep
    Study

    sheepn: not reported in source

    24 h fasted sheep
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (sheep).

    Source sentences

    Summary
    Studies in 24 h fasted (but not fed) sheep determined that ICV injection of Kp-10 can increase plasma GH concentrations.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In fed sheep, intracerebroventricular Kp-10 did not increase plasma growth hormone concentrations.

    In plain wordsIn fed sheep, kisspeptin‑10 given into the brain did not raise growth hormone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma GH in fed sheep
    Study

    sheepn: not reported in source

    Fed sheep
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (sheep).

    Source sentences

    Summary
    Studies in 24 h fasted (but not fed) sheep determined that ICV injection of Kp-10 can increase plasma GH concentrations.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In sheep, intracerebroventricular kisspeptin increased cFOS in NPY and GHRH cells of the arcuate nucleus.

    In plain wordsIn sheep, kisspeptin given into the brain switched on more NPY and GHRH cells in one brain region.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasecFOS in NPY and GHRH cells of the arcuate nucleus
    Study

    sheepn: not reported in source

    Arcuate nucleus
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (sheep).

    Source sentences

    Summary
    Indeed, KP injected ICV upregulated cFOS in NPY and GH Releasing Hormone (GHRH) cells in the arcuate nucleus and reduced cFOS in Somatostatin (SS) cells in the periventricular nucleus.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In sheep, intracerebroventricular kisspeptin reduced cFOS in somatostatin cells of the periventricular nucleus.

    In plain wordsIn sheep, kisspeptin given into the brain lowered activity in somatostatin cells in one brain region.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasecFOS in somatostatin cells of the periventricular nucleus
    Study

    sheepn: not reported in source

    Periventricular nucleus
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (sheep).

    Source sentences

    Summary
    Indeed, KP injected ICV upregulated cFOS in NPY and GH Releasing Hormone (GHRH) cells in the arcuate nucleus and reduced cFOS in Somatostatin (SS) cells in the periventricular nucleus.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In sheep, pretreatment with the NPY receptor antagonist BIBO 3304 blocked the kisspeptin-induced increase in growth hormone.

    In plain wordsIn sheep, a blocker of the NPY receptor stopped the growth hormone rise caused by kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKP-induced GH increase with NPY receptor antagonist BIBO 3304
    Study

    sheepn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Pretreatment of BIBO 3304, an NPY receptor antagonist, blocked the effect of KP to increase GH and implicated NPY as a mediator of the KP effect.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 06AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In sheep, blocking ghrelin release or ghrelin receptors in the brain reduced or blocked growth hormone release after kisspeptin treatment.

    In plain wordsIn sheep, blocking ghrelin lowered or stopped the growth hormone release caused by kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKP-induced GH release with ghrelin blockade
    Study

    sheepn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Both blockage of Ghrelin release and central blockade of Ghrelin receptors reduced or blocked release of GH after KP treatment.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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