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Study · Animal study (in vivo) · beagle dog · 2025

2 results

A biodegradable suction patch for sustainable transbuccal peptide delivery

Krupke H, Zoratto N, Rabut L, Gao D, Paunović N, Klein Cerrejon D, Dehapiot B, Leroux JC

Journal of Controlled Release1 Aug 2025

PepBankPUB-90427125
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    With the biodegradable buccal suction patch, bremelanotide had a relative bioavailability of 26% compared with subcutaneous administration.

    In plain wordsIn animal tests, a dissolvable cheek patch delivered 26% as much bremelanotide as an injection under the skin.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    Not applicableRelative bioavailability via buccal suction patch
    Study

    n: not reported in source

    Biodegradable buccal suction patch
    Comparator
    Subcutaneous administration
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · buccal suction patchAs given in this study.

    Measurements

    Relative bioavailability
    26%
    buccal patch vs subcutaneous

    Source sentences

    Summary
    Additionally, the patch achieved a relative bioavailability of 26% for bremelanotide (1.03 kDa) compared to subcutaneous administration.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In beagle dogs, a biodegradable buccal suction patch applied for 10 min gave substantially higher semaglutide bioavailability than the commercial tablet.

    In plain wordsIn beagle dogs, semaglutide from a buccal patch applied for 10 minutes was absorbed much better than from the commercial tablet.

    Peptide
    Semaglutide
    Outcome
    IncreaseSemaglutide bioavailability with buccal suction patch
    Study

    Beagle dogn: not reported in source

    Biodegradable buccal suction patch in vivo
    Comparator
    Commercial semaglutide tablet
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · buccal (suction patch) · 10 min applicationAs given in this study (Beagle dog).

    Measurements

    Application time
    10 min
    buccal suction patch

    Source sentences

    Summary
    In beagle dogs, the bioavailability of semaglutide (4.11 kDa) was substantially improved compared to the commercially available tablet, with an application time of only 10 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 38Current

    28 Oct 2026, 02:04 UTC

    The same notice was added 36 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:06 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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