Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs

Bozkurt G, Agaoglu AR, Aslan S, Wehrend A, Cortu A, Tepik FZ, Schäfer-Somi S

Theriogenology1 Jan 2026

PepBankPUB-90263504

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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anestrus female dogs, intravenous KP-10 alone significantly increased serum LH in a dose-dependent manner.
In plain wordsIn female dogs, KP-10 alone raised luteinizing hormone, and a higher dose raised it more.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum LH after KP-10 alone
Study
dogn = 10
Anestrus female dogs
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 and 1 ug/kg · intravenous · single doseAs given in this study (dog).
Source sentences
Summary
Results showed that LH and FSH concentrations increased significantly in a dose-dependent manner in groups receiving KP-10 alone (G4, G5), with G2 showing the lowest increase.
2 context sentences(design, population, supporting numbers)
Summary · context
Group 1 (G1, n = 4) received CB with saline; Group 2 (G2, n = 4) received 0.5 μg/kg KP-10 + CB; Group 3 (G3, n = 5) received 1 μg/kg KP-10 + CB; Group 4 (G4, n = 5) received 0.5 μg/kg KP-10 alone; and Group 5 (G5, n = 5) received 1 μg/kg KP-10 alone.
Summary · context
KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
Report a problemFND-9026350401
02AnimalAnimal study (in vivo)Efficacy outcome
In anestrus female dogs, intravenous KP-10 alone significantly increased serum FSH in a dose-dependent manner.
In plain wordsIn female dogs, KP-10 alone raised follicle-stimulating hormone, and a higher dose raised it more.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum FSH after KP-10 alone
Study
dogn = 10
Anestrus female dogs
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 and 1 ug/kg · intravenous · single doseAs given in this study (dog).
Source sentences
Summary
Results showed that LH and FSH concentrations increased significantly in a dose-dependent manner in groups receiving KP-10 alone (G4, G5), with G2 showing the lowest increase.
2 context sentences(design, population, supporting numbers)
Summary · context
Group 1 (G1, n = 4) received CB with saline; Group 2 (G2, n = 4) received 0.5 μg/kg KP-10 + CB; Group 3 (G3, n = 5) received 1 μg/kg KP-10 + CB; Group 4 (G4, n = 5) received 0.5 μg/kg KP-10 alone; and Group 5 (G5, n = 5) received 1 μg/kg KP-10 alone.
Summary · context
KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
Report a problemFND-9026350402

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In anestrus female dogs, estradiol increased in all groups, including cabergoline with saline, without reaching proestrus levels.
In plain wordsIn female dogs, estradiol rose in every group, including the group without KP-10, but did not reach proestrus levels.
Peptide
Kisspeptin-10
Outcome
IncreaseEstradiol across groups
Study
dogn = 23
Anestrus female dogs
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
E2 levels increased in all groups, although not reaching proestrus levels.
2 context sentences(design, population, supporting numbers)
Summary · context
Group 1 (G1, n = 4) received CB with saline; Group 2 (G2, n = 4) received 0.5 μg/kg KP-10 + CB; Group 3 (G3, n = 5) received 1 μg/kg KP-10 + CB; Group 4 (G4, n = 5) received 0.5 μg/kg KP-10 alone; and Group 5 (G5, n = 5) received 1 μg/kg KP-10 alone.
Summary · context
KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-9026350404
04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In anestrus female dogs, KP-10 at 1 ug/kg, given alone or with cabergoline, stimulated LH and FSH release but did not induce clinical estrus.
In plain wordsIn female dogs, KP-10 at 1 ug/kg, alone or with cabergoline, raised hormones but did not bring on clinical heat.
Peptide
Kisspeptin-10
Outcome
No significant changeClinical estrus after KP-10 at 1 ug/kg
Study
dogn = 10
Anestrus female dogs
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
KP-10, particularly at 1 μg/kg (G3, G5), effectively stimulated LH and FSH release but did not induce clinical estrus.
2 context sentences(design, population, supporting numbers)
Summary · context
Group 1 (G1, n = 4) received CB with saline; Group 2 (G2, n = 4) received 0.5 μg/kg KP-10 + CB; Group 3 (G3, n = 5) received 1 μg/kg KP-10 + CB; Group 4 (G4, n = 5) received 0.5 μg/kg KP-10 alone; and Group 5 (G5, n = 5) received 1 μg/kg KP-10 alone.
Summary · context
KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-9026350405
05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In anestrus female dogs given 1 ug/kg KP-10 plus cabergoline (G3), only this group showed a progesterone increase above 2 ng/mL on day 15, suggesting possible luteinization.
In plain wordsIn female dogs given KP-10 with cabergoline, only one group had progesterone above 2 ng/mL on day 15.
Peptide
Kisspeptin-10
Outcome
IncreaseProgesterone on day 15 after KP-10 plus cabergoline
Study
dogn = 5
Anestrus female dogs
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Progesterone
> 2 ng/mL
G3, day 15
Source sentences
Summary
Only G3 exhibited a P4 increase above 2 ng/mL on day 15, suggesting possible luteinization.
2 context sentences(design, population, supporting numbers)
Summary · context
Group 1 (G1, n = 4) received CB with saline; Group 2 (G2, n = 4) received 0.5 μg/kg KP-10 + CB; Group 3 (G3, n = 5) received 1 μg/kg KP-10 + CB; Group 4 (G4, n = 5) received 0.5 μg/kg KP-10 alone; and Group 5 (G5, n = 5) received 1 μg/kg KP-10 alone.
Summary · context
KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-9026350403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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Publication types

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