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Study · Animal study (in vivo) · 2026

14 results

Carnosine drives mitochondrial biogenesis and skeletal muscle regeneration via Sirt1-mediated nuclear translocation of PGC-1α.

Liang Y, Song C, Xing L, Chen Y, Teng H, Tian B, Li S, Jin X, Tong H

Biochimica et biophysica acta. Molecular cell research15 Oct 2026

PMID42880457 (opens in a new tab)DOI10.1016/j.bbamcr.2026.120237 (opens in a new tab)PepBankPUB-42880457
Publisher pagePubMedAsk about this study
Jump to 14 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals, oral carnosine accelerated muscle injury repair.

    In plain wordsIn animals, oral carnosine accelerated muscle repair.

    Peptide
    L-carnosine
    Outcome
    IncreaseMuscle injury repair
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · oralAs given in this study.

    Source sentences

    Summary
    Animal experiments confirmed that oral carnosine could accelerate the repair of injury, increase regenerated muscle fibers on the 7th day, and up-regulate Pax7, myogenic differentiation 1 (MyoD) and myogenin (MyoG).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In animals, oral carnosine increased regenerated muscle fibers on the 7th day.

    In plain wordsIn animals, oral carnosine increased regenerated muscle fibers on the 7th day.

    Peptide
    L-carnosine
    Outcome
    IncreaseRegenerated muscle fibers
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · oralAs given in this study.

    Source sentences

    Summary
    Animal experiments confirmed that oral carnosine could accelerate the repair of injury, increase regenerated muscle fibers on the 7th day, and up-regulate Pax7, myogenic differentiation 1 (MyoD) and myogenin (MyoG).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In animals, oral carnosine increased Pax7 expression.

    In plain wordsIn animals, oral carnosine increased Pax7 expression.

    Peptide
    L-carnosine
    Outcome
    IncreasePax7 expression
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · oralAs given in this study.

    Source sentences

    Summary
    Animal experiments confirmed that oral carnosine could accelerate the repair of injury, increase regenerated muscle fibers on the 7th day, and up-regulate Pax7, myogenic differentiation 1 (MyoD) and myogenin (MyoG).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In animals, oral carnosine increased MyoD expression.

    In plain wordsIn animals, oral carnosine increased MyoD expression.

    Peptide
    L-carnosine
    Outcome
    IncreaseMyoD expression
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · oralAs given in this study.

    Source sentences

    Summary
    Animal experiments confirmed that oral carnosine could accelerate the repair of injury, increase regenerated muscle fibers on the 7th day, and up-regulate Pax7, myogenic differentiation 1 (MyoD) and myogenin (MyoG).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In animals, oral carnosine increased MyoG expression.

    In plain wordsIn animals, oral carnosine increased MyoG expression.

    Peptide
    L-carnosine
    Outcome
    IncreaseMyoG expression
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · oralAs given in this study.

    Source sentences

    Summary
    Animal experiments confirmed that oral carnosine could accelerate the repair of injury, increase regenerated muscle fibers on the 7th day, and up-regulate Pax7, myogenic differentiation 1 (MyoD) and myogenin (MyoG).
  6. 06LabIn vitro (cells)Mechanism

    In mouse C2C12 myoblasts, carnosine promoted proliferation.

    In plain wordsIn cells, carnosine promoted mouse muscle cell proliferation.

    Peptide
    L-carnosine
    Outcome
    IncreaseMyoblast proliferation
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study shows carnosine promotes mouse C2C12 myoblast proliferation, up-regulates mitochondrial genes, and activates oxidative phosphorylation and ATP synthesis.
  7. 07LabIn vitro (cells)Mechanism

    In mouse C2C12 myoblasts, carnosine increased mitochondrial gene expression.

    In plain wordsIn cells, carnosine increased mitochondrial gene expression.

    Peptide
    L-carnosine
    Outcome
    IncreaseMitochondrial gene expression
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study shows carnosine promotes mouse C2C12 myoblast proliferation, up-regulates mitochondrial genes, and activates oxidative phosphorylation and ATP synthesis.
  8. 08LabIn vitro (cells)Mechanism

    In mouse C2C12 myoblasts, carnosine activated oxidative phosphorylation.

    In plain wordsIn cells, carnosine activated oxidative phosphorylation.

    Peptide
    L-carnosine
    Outcome
    IncreaseOxidative phosphorylation
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study shows carnosine promotes mouse C2C12 myoblast proliferation, up-regulates mitochondrial genes, and activates oxidative phosphorylation and ATP synthesis.
  9. 09LabIn vitro (cells)Mechanism

    In mouse C2C12 myoblasts, carnosine activated ATP synthesis.

    In plain wordsIn cells, carnosine increased ATP production.

    Peptide
    L-carnosine
    Outcome
    IncreaseATP synthesis
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study shows carnosine promotes mouse C2C12 myoblast proliferation, up-regulates mitochondrial genes, and activates oxidative phosphorylation and ATP synthesis.
    1 context sentence
    Summary · context
    In mechanism, it promotes PGC-1α nuclear translocation, TFAM expression, mitochondrial biogenesis and ATP production.
  10. 10LabIn vitro (cells)Mechanism

    In myoblasts, carnosine promoted PGC-1α nuclear translocation.

    In plain wordsIn cells, carnosine promoted movement of PGC-1α into the nucleus.

    Peptide
    L-carnosine
    Outcome
    IncreasePGC-1α nuclear translocation
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mechanism, it promotes PGC-1α nuclear translocation, TFAM expression, mitochondrial biogenesis and ATP production.
  11. 11LabIn vitro (cells)Mechanism

    In myoblasts, carnosine promoted TFAM expression.

    In plain wordsIn cells, carnosine increased TFAM expression.

    Peptide
    L-carnosine
    Outcome
    IncreaseTFAM expression
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mechanism, it promotes PGC-1α nuclear translocation, TFAM expression, mitochondrial biogenesis and ATP production.
  12. 12LabIn vitro (cells)Mechanism

    In myoblasts, carnosine promoted mitochondrial biogenesis.

    In plain wordsIn cells, carnosine promoted mitochondrial formation.

    Peptide
    L-carnosine
    Outcome
    IncreaseMitochondrial biogenesis
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mechanism, it promotes PGC-1α nuclear translocation, TFAM expression, mitochondrial biogenesis and ATP production.
  13. 13LabIn vitro (cells)Mechanism

    In myoblasts, carnosine induced Sirt1 nuclear accumulation, which EX-527 eliminated.

    In plain wordsIn cells, carnosine increased nuclear Sirt1, and EX-527 blocked this effect.

    Peptide
    L-carnosine
    Outcome
    IncreaseSirt1 nuclear accumulation
    Study

    mousen: not reported in source

    C2C12 myoblasts
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacological inhibition of Sirt1 by EX-527 eliminated the nuclear accumulation of Sirt1 and PGC-1α induced by carnosine, which confirmed that Sirt1 is an important mediator.

Studies that did not test the peptide alone1

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 14Computer modelNot a test of L-carnosine aloneIn silicoMechanism

    Molecular docking predicted that carnosine could bind Sirt1.

    In plain wordsA computer model predicted that carnosine could bind Sirt1.

    Peptide
    L-carnosine
    Outcome
    Not applicableSirt1 binding
    Study

    n: not reported in source

    Molecular docking
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Molecular docking showed that carnosine could bind to Sirt1 protein.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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