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Study · Animal study (in vivo) · rat · 2026

14 results

Kisspeptin-10 Alleviates Obesity-induced Testicular Oxidative Stress and Mitochondrial Dysfunction via Modulation of Mitophagy and Autophagy Signaling.

Arkalı G, Çay M, Güler Ekmen E, Acısu TC, Fi̇ri̇k M, Toz A, Yüce A, Aksakal M

Reproductive sciences (Thousand Oaks, Calif.)28 Sept 2026

PMID42806235 (opens in a new tab)DOI10.1007/s43032-026-02211-7 (opens in a new tab)PepBankPUB-42806235
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 reduced oxidative stress by lowering testicular malondialdehyde.

    In plain wordsIn obese rats, Kisspeptin‑10 lowered a marker of oxidative damage in the testes.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTesticular malondialdehyde (MDA)
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Kisspeptin-10 reduced oxidative stress by lowering malondialdehyde (MDA) and increasing glutathione (GSH) levels, improved sperm motility and concentration, reduced tail abnormal sperm ratio, showed a non-significant tendency toward partial restoration of mitochondrial function, decreased DNA damage…
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 increased testicular glutathione levels.

    In plain wordsIn obese rats, Kisspeptin‑10 raised a natural antioxidant in the testes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTesticular glutathione (GSH)
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Kisspeptin-10 reduced oxidative stress by lowering malondialdehyde (MDA) and increasing glutathione (GSH) levels, improved sperm motility and concentration, reduced tail abnormal sperm ratio, showed a non-significant tendency toward partial restoration of mitochondrial function, decreased DNA damage…
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 improved sperm motility.

    In plain wordsIn obese rats, Kisspeptin‑10 improved how well sperm moved.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSperm motility
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    improved sperm motility and concentration, reduced tail abnormal sperm ratio, showed a non-significant tendency toward partial restoration of mitochondrial function, decreased DNA damage, and increased prostate weight.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 improved sperm concentration.

    In plain wordsIn obese rats, Kisspeptin‑10 raised sperm concentration.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSperm concentration
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    improved sperm motility and concentration, reduced tail abnormal sperm ratio, showed a non-significant tendency toward partial restoration of mitochondrial function, decreased DNA damage, and increased prostate weight.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 reduced the ratio of sperm with tail abnormalities.

    In plain wordsIn obese rats, Kisspeptin‑10 lowered the share of sperm with tail defects.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTail abnormal sperm ratio
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    reduced tail abnormal sperm ratio, showed a non-significant tendency toward partial restoration of mitochondrial function, decreased DNA damage, and increased prostate weight.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 showed only a non-significant tendency toward partial restoration of mitochondrial function.

    In plain wordsIn obese rats, Kisspeptin‑10 did not clearly restore sperm mitochondrial function; the trend was not significant.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeSperm mitochondrial function
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    showed a non-significant tendency toward partial restoration of mitochondrial function, decreased DNA damage, and increased prostate weight.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 decreased sperm DNA damage.

    In plain wordsIn obese rats, Kisspeptin‑10 reduced DNA damage in sperm.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSperm DNA damage
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    decreased DNA damage, and increased prostate weight.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, Kisspeptin‑10 increased prostate weight.

    In plain wordsIn obese rats, Kisspeptin‑10 increased the weight of the prostate.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseProstate weight
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    increased prostate weight.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In obese rats, Kisspeptin‑10 was associated with increased testicular expression of the mitophagy protein PINK1.

    In plain wordsIn obese rats, Kisspeptin‑10 was linked to higher levels of a protein that clears damaged mitochondria.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePINK1 expression
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    It was also associated with increased expression of the mitophagy-related proteins PTEN-induced putative kinase 1 (PINK1) and Prohibitin 2 (PHB2), and increased Beclin-1 expression, with no significant effects on Parkin, Microtubule-associated protein 1 light chain 3-II (LC3-II), or apoptosis-related proteins.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In obese rats, Kisspeptin‑10 was associated with increased testicular expression of the mitophagy protein PHB2.

    In plain wordsIn obese rats, Kisspeptin‑10 was linked to higher levels of a protein that clears damaged mitochondria.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePHB2 expression
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    It was also associated with increased expression of the mitophagy-related proteins PTEN-induced putative kinase 1 (PINK1) and Prohibitin 2 (PHB2), and increased Beclin-1 expression, with no significant effects on Parkin, Microtubule-associated protein 1 light chain 3-II (LC3-II), or apoptosis-related proteins.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In obese rats, Kisspeptin‑10 was associated with increased testicular expression of Beclin-1.

    In plain wordsIn obese rats, Kisspeptin‑10 was linked to higher levels of an autophagy-related protein.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseBeclin-1 expression
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    It was also associated with increased expression of the mitophagy-related proteins PTEN-induced putative kinase 1 (PINK1) and Prohibitin 2 (PHB2), and increased Beclin-1 expression, with no significant effects on Parkin, Microtubule-associated protein 1 light chain 3-II (LC3-II), or apoptosis-related proteins.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In obese rats, Kisspeptin‑10 had no significant effect on Parkin expression.

    In plain wordsIn obese rats, Kisspeptin‑10 did not change the level of the protein Parkin.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeParkin expression
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    It was also associated with increased expression of the mitophagy-related proteins PTEN-induced putative kinase 1 (PINK1) and Prohibitin 2 (PHB2), and increased Beclin-1 expression, with no significant effects on Parkin, Microtubule-associated protein 1 light chain 3-II (LC3-II), or apoptosis-related proteins.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In obese rats, Kisspeptin‑10 had no significant effect on LC3-II expression.

    In plain wordsIn obese rats, Kisspeptin‑10 did not change the level of the autophagy protein LC3-II.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLC3-II expression
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    It was also associated with increased expression of the mitophagy-related proteins PTEN-induced putative kinase 1 (PINK1) and Prohibitin 2 (PHB2), and increased Beclin-1 expression, with no significant effects on Parkin, Microtubule-associated protein 1 light chain 3-II (LC3-II), or apoptosis-related proteins.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In obese rats, Kisspeptin‑10 had no significant effect on apoptosis-related proteins.

    In plain wordsIn obese rats, Kisspeptin‑10 did not change proteins linked to programmed cell death.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeApoptosis-related protein expression
    Study

    ratn: not reported in source

    Sprague Dawley rats, high-fat diet-induced obesity
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    It was also associated with increased expression of the mitophagy-related proteins PTEN-induced putative kinase 1 (PINK1) and Prohibitin 2 (PHB2), and increased Beclin-1 expression, with no significant effects on Parkin, Microtubule-associated protein 1 light chain 3-II (LC3-II), or apoptosis-related proteins.
    2 context sentences
    Summary · context
    Forty male Sprague Dawley rats were divided into four groups: Control, Obesity, Kisspeptin-10, and Obesity+Kisspeptin-10.
    Summary · context
    Kisspeptin-10 (50 nmol/kg, i.p.) was administered to both the Kisspeptin-10 and Obesity+Kisspeptin-10 groups from week 13 to week 16.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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