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Study · Animal study (in vivo) · mouse · 2026

6 results

Histopathological and immunohistochemical characterization of MPTP-associated pancreatic injury and its attenuation by Hexarelin in mice.

Şahin M, Topsakal Ş, Elmas O, Özmen Ö

Journal of molecular histology18 Sept 2026

PMID42758352 (opens in a new tab)DOI10.1007/s10735-026-10976-z (opens in a new tab)PepBankPUB-42758352
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-associated pancreatic injury, hexarelin treatment attenuated the histopathological alterations in both treatment groups.

    In plain wordsIn mice with MPTP-induced pancreatic injury, hexarelin reduced the tissue damage seen under the microscope.

    Peptide
    Hexarelin
    Outcome
    DecreasePancreatic histopathological alterations
    Study

    mousen: not reported in source

    MPTP-induced pancreatic injury
    Outcome group
    Organ injury · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment attenuated these histopathological and immunohistochemical alterations in both treatment groups, although the magnitude of improvement varied among individual markers.
    2 context sentences
    Summary · context
    MPTP administration was associated with marked pancreatic injury characterized by acinar degeneration, cytoplasmic vacuolization, vascular congestion, interstitial edema, inflammatory cell infiltration, and degeneration of the islets of Langerhans.
    Summary · context
    Fifty male BALB/c mice were randomly assigned to five groups (n = 10/group): Sham, MPTP, Hexarelin, PreHexarelin, and PostHexarelin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-associated pancreatic injury, hexarelin attenuated the increased inflammatory marker immunoreactivity, though the size of improvement varied among markers.

    In plain wordsIn mice with MPTP-induced pancreatic injury, hexarelin reduced inflammation markers in the pancreas, by different amounts for different markers.

    Peptide
    Hexarelin
    Outcome
    DecreaseInflammatory marker immunoreactivity (CD11b, CD68, IL-1β, TNF-α)
    Study

    mousen: not reported in source

    MPTP-induced pancreatic injury
    Outcome group
    Inflammation markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment attenuated these histopathological and immunohistochemical alterations in both treatment groups, although the magnitude of improvement varied among individual markers.
    2 context sentences
    Summary · context
    Immunohistochemical analysis demonstrated increased inflammatory (CD11b, CD68, IL-1β, and TNF-α) and apoptosis-associated (caspase-3) marker immunoreactivity, together with increased β-amyloid immunoreactivity and decreased insulin and amylin immunoreactivities.
    Summary · context
    Fifty male BALB/c mice were randomly assigned to five groups (n = 10/group): Sham, MPTP, Hexarelin, PreHexarelin, and PostHexarelin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-associated pancreatic injury, hexarelin attenuated the increased caspase-3 apoptosis marker immunoreactivity, though the size of improvement varied among markers.

    In plain wordsIn mice with MPTP-induced pancreatic injury, hexarelin reduced a cell-death marker in the pancreas.

    Peptide
    Hexarelin
    Outcome
    DecreaseCaspase-3 immunoreactivity
    Study

    mousen: not reported in source

    MPTP-induced pancreatic injury
    Outcome group
    Organ injury · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment attenuated these histopathological and immunohistochemical alterations in both treatment groups, although the magnitude of improvement varied among individual markers.
    2 context sentences
    Summary · context
    Immunohistochemical analysis demonstrated increased inflammatory (CD11b, CD68, IL-1β, and TNF-α) and apoptosis-associated (caspase-3) marker immunoreactivity, together with increased β-amyloid immunoreactivity and decreased insulin and amylin immunoreactivities.
    Summary · context
    Fifty male BALB/c mice were randomly assigned to five groups (n = 10/group): Sham, MPTP, Hexarelin, PreHexarelin, and PostHexarelin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-associated pancreatic injury, hexarelin attenuated the increased β-amyloid immunoreactivity, though the size of improvement varied among markers.

    In plain wordsIn mice with MPTP-induced pancreatic injury, hexarelin reduced a protein-deposit marker in the pancreas.

    Peptide
    Hexarelin
    Outcome
    Decreaseβ-amyloid immunoreactivity
    Study

    mousen: not reported in source

    MPTP-induced pancreatic injury
    Outcome group
    Organ injury · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment attenuated these histopathological and immunohistochemical alterations in both treatment groups, although the magnitude of improvement varied among individual markers.
    2 context sentences
    Summary · context
    Immunohistochemical analysis demonstrated increased inflammatory (CD11b, CD68, IL-1β, and TNF-α) and apoptosis-associated (caspase-3) marker immunoreactivity, together with increased β-amyloid immunoreactivity and decreased insulin and amylin immunoreactivities.
    Summary · context
    Fifty male BALB/c mice were randomly assigned to five groups (n = 10/group): Sham, MPTP, Hexarelin, PreHexarelin, and PostHexarelin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-associated pancreatic injury, hexarelin attenuated the decrease in insulin and amylin immunoreactivity, with partial preservation of endocrine-marker immunoreactivity.

    In plain wordsIn mice with MPTP-induced pancreatic injury, hexarelin partly kept the insulin and amylin signals in the pancreas.

    Peptide
    Hexarelin
    Outcome
    IncreaseInsulin and amylin immunoreactivity
    Study

    mousen: not reported in source

    MPTP-induced pancreatic injury
    Outcome group
    Organ injury · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment was associated with attenuation of these pathological changes and partial preservation of islet morphology and endocrine-marker immunoreactivity
    2 context sentences
    Summary · context
    Immunohistochemical analysis demonstrated increased inflammatory (CD11b, CD68, IL-1β, and TNF-α) and apoptosis-associated (caspase-3) marker immunoreactivity, together with increased β-amyloid immunoreactivity and decreased insulin and amylin immunoreactivities.
    Summary · context
    Fifty male BALB/c mice were randomly assigned to five groups (n = 10/group): Sham, MPTP, Hexarelin, PreHexarelin, and PostHexarelin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-associated pancreatic injury, hexarelin treatment was associated with partial preservation of islet morphology.

    In plain wordsIn mice with MPTP-induced pancreatic injury, hexarelin was linked to partly better-preserved islet structure in the pancreas.

    Peptide
    Hexarelin
    Outcome
    IncreaseIslet morphology
    Study

    mousen: not reported in source

    MPTP-induced pancreatic injury
    Outcome group
    Organ injury · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment was associated with attenuation of these pathological changes and partial preservation of islet morphology and endocrine-marker immunoreactivity
    1 context sentence
    Summary · context
    Fifty male BALB/c mice were randomly assigned to five groups (n = 10/group): Sham, MPTP, Hexarelin, PreHexarelin, and PostHexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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