[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].

Li CY, Zhang NN, Yang YL, Zhao SS, Xu XF, Cao PY

Zhonghua xin xue guan bing za zhi1 Sept 2026

PMID42736132DOI10.3760/cma.j.cn112148-20260515-00320PepBankPUB-42736132

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In hospitalized adults with acute exacerbation of chronic heart failure, a higher serum Humanin/CRP ratio was associated with lower risk of MACE.
In plain wordsIn people hospitalized for worsening heart failure, a higher ratio of natural humanin to CRP was linked to fewer major cardiovascular events.
Peptide
Humanin
Outcome
DecreaseHumanin/CRP ratio and MACE risk (Cox regression)
Study
n = 154
Outcome group
Cardiovascular events · Cardiovascular
Measurements
Hazard ratio
0.999
Humanin/CRP ratio
95% CI
0.998 to 1
Humanin/CRP ratio
Source sentences
Summary
Multivariate Cox regression analysis showed that Humanin/CRP ratio was negatively correlated with MACE risk (HR=0.999, 95%CI: 0.998-1.000, P=0.011).
1 context sentence(design, population, supporting numbers)
Summary · context
This non-randomized retrospective cohort study consecutively enrolled patients with acute exacerbation of CHF admitted to the Third Affiliated Hospital of Nanjing Medical University from March to November 2025.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4273613201
02HumanEndogenous levelObservational studyOther
In hospitalized adults with acute exacerbation of chronic heart failure, the serum Humanin/CRP ratio predicted MACE with a sensitivity of 92.5%.
In plain wordsIn people hospitalized for worsening heart failure, the natural humanin to CRP ratio correctly flagged most who later had major cardiovascular events.
Peptide
Humanin
Outcome
Not applicableHumanin/CRP ratio ROC sensitivity for MACE
Study
n = 154
Outcome group
Cardiovascular events · Cardiovascular
Measurements
Sensitivity
92.5%
Humanin/CRP ratio
Source sentences
Summary
Receiver operating characteristic curve analysis indicated that the ratio predicted MACE with a sensitivity of 92.5% and a specificity of 27.5%.
1 context sentence(design, population, supporting numbers)
Summary · context
This non-randomized retrospective cohort study consecutively enrolled patients with acute exacerbation of CHF admitted to the Third Affiliated Hospital of Nanjing Medical University from March to November 2025.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4273613202
03HumanEndogenous levelObservational studyOther
In hospitalized adults with acute exacerbation of chronic heart failure, the serum Humanin/CRP ratio predicted MACE with a specificity of 27.5%.
In plain wordsIn people hospitalized for worsening heart failure, the natural humanin to CRP ratio often wrongly flagged people without major cardiovascular events.
Peptide
Humanin
Outcome
Not applicableHumanin/CRP ratio ROC specificity for MACE
Study
n = 154
Outcome group
Cardiovascular events · Cardiovascular
Measurements
Specificity
27.5%
Humanin/CRP ratio
Source sentences
Summary
Receiver operating characteristic curve analysis indicated that the ratio predicted MACE with a sensitivity of 92.5% and a specificity of 27.5%.
1 context sentence(design, population, supporting numbers)
Summary · context
This non-randomized retrospective cohort study consecutively enrolled patients with acute exacerbation of CHF admitted to the Third Affiliated Hospital of Nanjing Medical University from March to November 2025.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4273613203
04HumanEndogenous levelObservational studyOther
In hospitalized adults with acute exacerbation of chronic heart failure, 6-month MACE-free survival was lower in the low Humanin/CRP ratio subgroup than in the high ratio subgroup.
In plain wordsIn people hospitalized for heart failure, those with a low natural humanin to CRP ratio had less event-free survival than those with a high ratio.
Peptide
Humanin
Outcome
Decrease6-month MACE-free survival by Humanin/CRP ratio
Study
n = 154
Outcome group
Cardiovascular events · Cardiovascular
Source sentences
Summary
Kaplan-Meier survival curves demonstrated that the 6-month cumulative MACE-free survival rate was significantly lower in the low Humanin/CRP ratio subgroup than in the high ratio subgroup (log-rank P=0.008).
1 context sentence(design, population, supporting numbers)
Summary · context
This non-randomized retrospective cohort study consecutively enrolled patients with acute exacerbation of CHF admitted to the Third Affiliated Hospital of Nanjing Medical University from March to November 2025.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4273613204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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