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Study · Animal study (in vivo) · rat · 2026

6 results

Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.

Jaldhi, Kumar S, Shanker OR, Banerjee J, Dixit AB, Maurya SK, Bakshi A

Molecular neurobiology1 Sept 2026

PMID42680947 (opens in a new tab)DOI10.1007/s12035-026-06171-6 (opens in a new tab)PepBankPUB-42680947
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with temporal lobe epilepsy, Kp-10 administration restored cellular alterations in the hippocampus.

    In plain wordsIn epileptic rats, Kp-10 reversed changes in the cell structure of the hippocampus.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedHippocampal cellular alterations
    Study

    ratn: not reported in source

    Lithium-pilocarpine temporal lobe epilepsy (TLE) rat model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 administration led to restoration of cellular alterations in the hippocampus of TLE rats.
    2 context sentences
    Summary · context
    Additionally, kisspeptin-10 (Kp-10) was administered to TLE rats, and its effects on cytoarchitecture, neuroinflammation, and long-term memory were evaluated.
    Summary · context
    To investigate this, a lithium-pilocarpine TLE rat model was established.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with temporal lobe epilepsy, Kp-10 treatment upregulated the anti-inflammatory cytokine Il-10 in the hippocampus and anterior temporal lobe.

    In plain wordsIn epileptic rats, Kp-10 raised an anti-inflammatory signal, Il-10, in two brain regions.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseIl-10 in hippocampus and ATL
    Study

    ratn: not reported in source

    Lithium-pilocarpine temporal lobe epilepsy (TLE) rat model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 treatment upregulated the levels of anti-inflammatory cytokine Il-10 in the hippocampus and ATL.
    2 context sentences
    Summary · context
    Additionally, kisspeptin-10 (Kp-10) was administered to TLE rats, and its effects on cytoarchitecture, neuroinflammation, and long-term memory were evaluated.
    Summary · context
    To investigate this, a lithium-pilocarpine TLE rat model was established.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with temporal lobe epilepsy, Kp-10 treatment downregulated the pro-inflammatory cytokine Il-1β in the hippocampus but did not change it in the anterior temporal lobe.

    In plain wordsIn epileptic rats, Kp-10 lowered an inflammation signal, Il-1β, in the hippocampus but not in another brain region.

    Peptide
    Kisspeptin-10
    Outcome
    MixedIl-1β in hippocampus and ATL
    Study

    ratn: not reported in source

    Lithium-pilocarpine temporal lobe epilepsy (TLE) rat model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A downregulation in the levels of pro-inflammatory cytokine Il-1β in the hippocampus, but no alteration in ATL was seen upon Kp-10 treatment.
    2 context sentences
    Summary · context
    Additionally, kisspeptin-10 (Kp-10) was administered to TLE rats, and its effects on cytoarchitecture, neuroinflammation, and long-term memory were evaluated.
    Summary · context
    To investigate this, a lithium-pilocarpine TLE rat model was established.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with temporal lobe epilepsy, Kp-10 treatment improved memory discrimination in the novel object recognition test.

    In plain wordsIn epileptic rats, Kp-10 improved performance in a memory test.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMemory discrimination in novel object recognition
    Study

    ratn: not reported in source

    Lithium-pilocarpine temporal lobe epilepsy (TLE) rat model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Novel object recognition test indicated improved memory discrimination in Kp-10-treated TLE rats.
    2 context sentences
    Summary · context
    Additionally, kisspeptin-10 (Kp-10) was administered to TLE rats, and its effects on cytoarchitecture, neuroinflammation, and long-term memory were evaluated.
    Summary · context
    To investigate this, a lithium-pilocarpine TLE rat model was established.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In rats with temporal lobe epilepsy, Kiss1 mRNA was significantly downregulated across brain regions.

    In plain wordsIn epileptic rats, the body's own kisspeptin gene activity was lower across brain regions.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKiss1 mRNA across brain regions
    Study

    ratn: not reported in source

    Lithium-pilocarpine temporal lobe epilepsy (TLE) rat model
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The results demonstrated significant downregulation of Kiss1 and Kiss1r mRNA across brain regions
    2 context sentences
    Summary · context
    (P < 0.05).
    Summary · context
    To investigate this, a lithium-pilocarpine TLE rat model was established.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In rats with temporal lobe epilepsy, Kiss1 protein was downregulated in the hippocampus and anterior temporal lobe but unchanged in the neocortex.

    In plain wordsIn epileptic rats, the body's own kisspeptin protein was lower in two brain regions and unchanged in a third.

    Peptide
    Kisspeptin-10
    Outcome
    MixedKiss1 protein by brain region
    Study

    ratn: not reported in source

    Lithium-pilocarpine temporal lobe epilepsy (TLE) rat model
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    At the protein level, Kiss1 was significantly downregulated in the hippocampus and ATL but remained unchanged in the neocortex.
    1 context sentence
    Summary · context
    To investigate this, a lithium-pilocarpine TLE rat model was established.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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