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Study · Measured the body's own peptide · 2026

3 results

Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome.

Korkmaz O, Karabulut S, Macit P

Journal of assisted reproduction and genetics28 Aug 2026

PMID42663893 (opens in a new tab)DOI10.1007/s10815-026-04014-w (opens in a new tab)PepBankPUB-42663893
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In women undergoing IVF, follicular fluid kisspeptin‑54 differed among groups and rose progressively from normoresponder controls to women with PCOS and those with OHSS.

    In plain wordsIn women having IVF, the body's own kisspeptin‑54 in follicular fluid was higher in women with PCOS and highest in women with OHSS.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseFollicular fluid kisspeptin-54 across controls, PCOS and OHSS
    Study

    n = 90

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Follicular fluid concentrations of Kisspeptin-1, Kisspeptin-54, and VEGF differed significantly among study groups (all p < 0.001), demonstrating a progressive increase from normoresponder controls to women with PCOS and those who developed OHSS.
    1 context sentence
    Summary · context
    In this retrospective cross-sectional study, 90 women undergoing IVF treatment were stratified into three groups: normoresponder controls (n = 30), women with PCOS (n = 30), and patients who developed OHSS (n = 30).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In women undergoing IVF, follicular fluid kisspeptin‑54 correlated positively with AMH, AFC, trigger-day estradiol, oocyte yield, MII oocyte count and good-quality embryos.

    In plain wordsIn women having IVF, higher natural kisspeptin‑54 in follicular fluid was linked to a stronger ovarian response.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseFollicular kisspeptin-54 and indicators of ovarian response
    Study

    n = 90

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Correlation coefficient
    0.41 to 0.78 r
    Kisspeptin-54 and VEGF with indicators of ovarian response

    Source sentences

    Summary
    Kisspeptin-54 and VEGF exhibited strong positive correlations with established indicators of ovarian response, including AMH, AFC, trigger-day estradiol levels, total oocyte yield, MII oocyte count, and the number of good-quality embryos (r = 0.41-0.78, all p < 0.001).
    1 context sentence
    Summary · context
    In this retrospective cross-sectional study, 90 women undergoing IVF treatment were stratified into three groups: normoresponder controls (n = 30), women with PCOS (n = 30), and patients who developed OHSS (n = 30).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In women undergoing IVF, follicular fluid kisspeptin‑54 remained significantly associated with OHSS occurrence in multivariable logistic regression.

    In plain wordsIn women having IVF, higher natural kisspeptin‑54 in follicular fluid was linked to a higher chance of OHSS.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseFollicular kisspeptin-54 and OHSS occurrence
    Study

    n = 90

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Odds ratio
    1.031
    OHSS occurrence

    Source sentences

    Summary
    In multivariable logistic regression analyses, Kisspeptin-54 (OR = 1.031) and VEGF (OR = 1.008), together with AFC, AMH, trigger-day estradiol, and total oocyte count, remained significantly associated with OHSS occurrence (all p < 0.01).
    1 context sentence
    Summary · context
    In this retrospective cross-sectional study, 90 women undergoing IVF treatment were stratified into three groups: normoresponder controls (n = 30), women with PCOS (n = 30), and patients who developed OHSS (n = 30).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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