In the liver of Nile tilapia infected with Streptococcus agalactiae, a thymosin β4 transcript was identified by RNA-seq and experimentally validated by qPCR for the first time.
In plain wordsIn Nile tilapia infected with a bacterium, the fish's own thymosin β4 gene was found active in the liver and confirmed by PCR.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Direction not reportedHepatic thymosin β4 transcript identified and validated by qPCR
- Study
Nile tilapia (Oreochromis niloticus)n: not reported in source
- Outcome group
- Infection and antimicrobial activity · Infection
Source sentences
Our transcriptomic profiling identified 13 high-confidence candidates: 7 classical candidates including two conserved transcripts (NK-lysin, hepcidin), two structural variants (piscidin 2, piscidin 3), and three (LEAP-2, thymosin β4, and lysozyme C) to be experimentally validated for the first time
1 context sentence(design, population, supporting numbers)
Putative candidates were evaluated via AlphaFold 3 structural modeling and validated in vivo through quantitative real-time PCR (qPCR) over a 48-h post-infection period.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.