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Study · Animal study (in vivo) · mouse · 2026

5 results

Protective and restorative effects of hexarelin on MPTP-induced lung injury in mice.

Celikoglu O, Karanfil ES, Ozmen O

Journal of basic and clinical physiology and pharmacology21 Aug 2026

PMID42619489 (opens in a new tab)DOI10.1515/jbcpp-2026-0178 (opens in a new tab)PepBankPUB-42619489
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-induced lung injury, both hexarelin regimens (before or after MPTP) significantly reduced lung histopathological damage.

    In plain wordsIn mice with MPTP-induced lung injury, hexarelin given before or after MPTP reduced damage seen in lung tissue.

    Peptide
    Hexarelin
    Outcome
    DecreaseLung histopathological damage
    Study

    mousen: not reported in source

    MPTP-induced lung injury
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    10 μg/kg twice · intraperitoneal · two injections 4 h apartAs given in this study (mouse).

    Source sentences

    Summary
    Both HEX regimens significantly reduced histopathological damage
    2 context sentences
    Summary · context
    Fifty male Balb/C mice were randomly assigned to five groups (n=10): control, MPTP, PREHEX, POSTHEX, and HEX.
    Summary · context
    Hexarelin (10 μg/kg, i.p.) was administered twice at 4-h intervals before or after MPTP exposure.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-induced lung injury, both hexarelin regimens significantly improved the immunohistochemical parameters (p<0.05).

    In plain wordsIn mice with MPTP-induced lung injury, hexarelin given before or after MPTP improved lung cell-damage and inflammation markers.

    Peptide
    Hexarelin
    Outcome
    MixedImmunohistochemical markers (Caspase-3, IL-6, SOD)
    Study

    mousen: not reported in source

    MPTP-induced lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 μg/kg twice · intraperitoneal · two injections 4 h apartAs given in this study (mouse).

    Source sentences

    Summary
    improved immunohistochemical parameters (p<0.05).
    2 context sentences
    Summary · context
    Fifty male Balb/C mice were randomly assigned to five groups (n=10): control, MPTP, PREHEX, POSTHEX, and HEX.
    Summary · context
    Hexarelin (10 μg/kg, i.p.) was administered twice at 4-h intervals before or after MPTP exposure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-induced lung injury, hexarelin after MPTP gave lower apoptotic marker expression than hexarelin before MPTP (p=0.005).

    In plain wordsIn mice with MPTP-induced lung injury, hexarelin given after MPTP lowered cell-death markers more than hexarelin given before.

    Peptide
    Hexarelin
    Outcome
    DecreaseApoptotic marker expression, post-treatment versus pretreatment
    Study

    mousen: not reported in source

    MPTP-induced lung injury
    Comparator
    Hexarelin before MPTP (PREHEX)
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    10 μg/kg twice · intraperitoneal · two injections 4 h apartAs given in this study (mouse).

    Source sentences

    Summary
    POSTHEX showed greater recovery than PREHEX, with lower apoptotic (p=0.005) and inflammatory (p=0.050) marker expression and higher SOD (p=0.007) levels.
    2 context sentences
    Summary · context
    Fifty male Balb/C mice were randomly assigned to five groups (n=10): control, MPTP, PREHEX, POSTHEX, and HEX.
    Summary · context
    Hexarelin (10 μg/kg, i.p.) was administered twice at 4-h intervals before or after MPTP exposure.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-induced lung injury, hexarelin after MPTP gave lower inflammatory marker expression than hexarelin before MPTP (p=0.050).

    In plain wordsIn mice with MPTP-induced lung injury, hexarelin given after MPTP lowered inflammation markers more than hexarelin given before.

    Peptide
    Hexarelin
    Outcome
    DecreaseInflammatory marker expression, post-treatment versus pretreatment
    Study

    mousen: not reported in source

    MPTP-induced lung injury
    Comparator
    Hexarelin before MPTP (PREHEX)
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 μg/kg twice · intraperitoneal · two injections 4 h apartAs given in this study (mouse).

    Source sentences

    Summary
    POSTHEX showed greater recovery than PREHEX, with lower apoptotic (p=0.005) and inflammatory (p=0.050) marker expression and higher SOD (p=0.007) levels.
    2 context sentences
    Summary · context
    Fifty male Balb/C mice were randomly assigned to five groups (n=10): control, MPTP, PREHEX, POSTHEX, and HEX.
    Summary · context
    Hexarelin (10 μg/kg, i.p.) was administered twice at 4-h intervals before or after MPTP exposure.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with MPTP-induced lung injury, hexarelin after MPTP gave higher SOD levels than hexarelin before MPTP (p=0.007).

    In plain wordsIn mice with MPTP-induced lung injury, hexarelin given after MPTP gave higher levels of the antioxidant enzyme SOD than hexarelin given before.

    Peptide
    Hexarelin
    Outcome
    IncreaseSOD level, post-treatment versus pretreatment
    Study

    mousen: not reported in source

    MPTP-induced lung injury
    Comparator
    Hexarelin before MPTP (PREHEX)
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    10 μg/kg twice · intraperitoneal · two injections 4 h apartAs given in this study (mouse).

    Source sentences

    Summary
    POSTHEX showed greater recovery than PREHEX, with lower apoptotic (p=0.005) and inflammatory (p=0.050) marker expression and higher SOD (p=0.007) levels.
    2 context sentences
    Summary · context
    Fifty male Balb/C mice were randomly assigned to five groups (n=10): control, MPTP, PREHEX, POSTHEX, and HEX.
    Summary · context
    Hexarelin (10 μg/kg, i.p.) was administered twice at 4-h intervals before or after MPTP exposure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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