Seminal Plasma Kisspeptin-1 and Kisspeptin-54 Levels Are Associated With Semen Parameters and Oxidative Stress in Male Infertility.

Korkmaz O, Karabulut S, Macit P

Clinical endocrinology7 Aug 2026

PMID42566672DOI10.1111/cen.70199PepBankPUB-42566672

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In men at an IVF centre, seminal plasma kisspeptin‑54 levels decreased with increasing infertility severity from normozoospermia to OAT to azoospermia.
In plain wordsIn men at an IVF centre, the body's own kisspeptin‑54 in semen was lower with more severe infertility.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseSeminal plasma kisspeptin-54 by infertility severity
Study
n = 50
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Kisspeptin-1 and Kisspeptin-54 levels showed a progressive decrease with increasing infertility severity (normozoospermia→OAT→azoospermia; p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667201
02HumanEndogenous levelObservational studyOther
In men at an IVF centre, seminal plasma kisspeptin levels were positively associated with sperm concentration.
In plain wordsIn men at an IVF centre, higher natural kisspeptin in semen was linked to higher sperm concentration.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseSeminal kisspeptin and sperm concentration
Study
n = 50
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Both kisspeptins were positively associated with sperm concentration and progressive motility, and negatively associated with TOC and OSI (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667202
03HumanEndogenous levelObservational studyOther
In men at an IVF centre, seminal plasma kisspeptin levels were positively associated with progressive sperm motility.
In plain wordsIn men at an IVF centre, higher natural kisspeptin in semen was linked to better sperm motility.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseSeminal kisspeptin and progressive motility
Study
n = 50
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Both kisspeptins were positively associated with sperm concentration and progressive motility, and negatively associated with TOC and OSI (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667203
04HumanEndogenous levelObservational studyOther
In men at an IVF centre, seminal plasma kisspeptin levels were negatively associated with total oxidant capacity.
In plain wordsIn men at an IVF centre, higher natural kisspeptin in semen was linked to lower oxidant load.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseSeminal kisspeptin and total oxidant capacity
Study
n = 50
Outcome group
Aging markers · Reproductive and sexual health
Source sentences
Summary
Both kisspeptins were positively associated with sperm concentration and progressive motility, and negatively associated with TOC and OSI (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667204
05HumanEndogenous levelObservational studyOther
In men at an IVF centre, seminal plasma kisspeptin levels were negatively associated with the oxidative stress index.
In plain wordsIn men at an IVF centre, higher natural kisspeptin in semen was linked to a lower oxidative stress index.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseSeminal kisspeptin and oxidative stress index
Study
n = 50
Outcome group
Aging markers · Reproductive and sexual health
Source sentences
Summary
Both kisspeptins were positively associated with sperm concentration and progressive motility, and negatively associated with TOC and OSI (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667205
06HumanEndogenous levelObservational studyOther
In regression analyses, seminal kisspeptin levels were significantly associated with sperm concentration.
In plain wordsIn men at an IVF centre, natural kisspeptin levels in semen were linked to sperm concentration after regression analysis.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseRegression of seminal kisspeptin on sperm concentration
Study
n = 50
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Regression analyses indicated that seminal kisspeptin levels were significantly associated with sperm concentration and progressive motility.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667206
07HumanEndogenous levelObservational studyOther
In regression analyses, seminal kisspeptin levels were significantly associated with progressive motility.
In plain wordsIn men at an IVF centre, natural kisspeptin levels in semen were linked to sperm motility after regression analysis.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseRegression of seminal kisspeptin on progressive motility
Study
n = 50
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Regression analyses indicated that seminal kisspeptin levels were significantly associated with sperm concentration and progressive motility.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty men attending an in vitro fertilization centre were classified into normozoospermia (n = 20), oligoasthenoteratozoospermia (OAT) (n = 18) and azoospermia (n = 12) groups according to WHO 2021 criteria.
Summary · context
Seminal plasma Kisspeptin-1 and Kisspeptin-54 levels were measured using ELISA.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4256667207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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